Husham Sharifi
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View article: Pirfenidone for the treatment of bronchiolitis obliterans syndrome related to chronic graft-versus-host disease
Pirfenidone for the treatment of bronchiolitis obliterans syndrome related to chronic graft-versus-host disease Open
Bronchiolitis obliterans syndrome (BOS) is a severe form of chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic cell transplant (HCT), with a 5-year survival rate of 40%. Currently, there is no curative therapy for…
View article: Macrophage ferroptosis inhibits <i>Aspergillus</i> conidial killing in lung transplantation
Macrophage ferroptosis inhibits <i>Aspergillus</i> conidial killing in lung transplantation Open
Immune suppression heightens the risk for fungal infections, but the mechanisms that result in clinical disease are poorly understood. Here we demonstrate that macrophage ferroptosis, an iron-dependent form of regulated cell death, inhibit…
View article: CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant
CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant Open
Bronchiolitis obliterans syndrome (BOS) after hematopoietic cell transplantation (HCT) is associated with substantial morbidity and mortality. Quantitative computed tomography (qCT) can help diagnose advanced BOS meeting National Institute…
View article: Variables associated with antibiotic treatment tolerance in patients with Mycobacterium avium complex pulmonary disease
Variables associated with antibiotic treatment tolerance in patients with Mycobacterium avium complex pulmonary disease Open
Background Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) involves prolonged courses of multiple antibiotics that are variably tolerated and commonly cause adverse drug reactions (ADR). The purpose of this retrospectiv…
View article: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic Open
Background The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. Despite th…
View article: α<sub>v</sub>β<sub>6</sub> Integrin Positron Emission Tomography of Lung Fibrosis in Idiopathic Pulmonary Fibrosis and Long COVID-19
α<sub>v</sub>β<sub>6</sub> Integrin Positron Emission Tomography of Lung Fibrosis in Idiopathic Pulmonary Fibrosis and Long COVID-19 Open
"αvβ6 Integrin Positron Emission Tomography of Lung Fibrosis in Idiopathic Pulmonary Fibrosis and Long-COVID." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –
View article: Coronavirus Disease-2019 Pneumonia
Coronavirus Disease-2019 Pneumonia Open
View article: A SEIRD+V Model for the Effect of Vaccination and Social Distancing on SARS-CoV-2 Infection and Mortality
A SEIRD+V Model for the Effect of Vaccination and Social Distancing on SARS-CoV-2 Infection and Mortality Open
We present a deterministic, calibrated Susceptible-Exposed-Infected-Recovered- Dead + Vaccinated (SEIRD+V) model that simulates the spread and containment of COVID-19. We use the model to compare the effectiveness of vaccination vs. social…
View article: A SEIRD+V Model for the Effect of Vaccination and Social Distancing on SARS-CoV-2 Infection and Mortality
A SEIRD+V Model for the Effect of Vaccination and Social Distancing on SARS-CoV-2 Infection and Mortality Open
We present a deterministic, calibrated Susceptible-Exposed-Infected-Recovered-Dead + Vaccinated (SEIRD+V) model that simulates the spread and containment of COVID-19. We use the model to compare the effectiveness of vaccination vs. social …
View article: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic Open
Summary Background The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. De…
View article: Epidemiology of Lower Respiratory Tract Infections and Community-Acquired Respiratory Viruses in Patients with Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation: A Retrospective Cohort Study
Epidemiology of Lower Respiratory Tract Infections and Community-Acquired Respiratory Viruses in Patients with Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation: A Retrospective Cohort Study Open
View article: Graft-versus-host disease may cause pulmonary restriction, but not all restriction is graft-versus-host disease
Graft-versus-host disease may cause pulmonary restriction, but not all restriction is graft-versus-host disease Open
View article: The safety and tolerability of pirfenidone for bronchiolitis obliterans syndrome after hematopoietic cell transplant (STOP-BOS) trial
The safety and tolerability of pirfenidone for bronchiolitis obliterans syndrome after hematopoietic cell transplant (STOP-BOS) trial Open
View article: Pragmatic Application of Computed Tomography Lung Texture Analysis in Immune Checkpoint Inhibitor Pneumonitis: An Exploratory Study
Pragmatic Application of Computed Tomography Lung Texture Analysis in Immune Checkpoint Inhibitor Pneumonitis: An Exploratory Study Open
View article: The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation
The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation Open
View article: Radiology–Pathology Correlation Demonstrating Organizing Pneumonia in a Patient Who Recovered from COVID-19
Radiology–Pathology Correlation Demonstrating Organizing Pneumonia in a Patient Who Recovered from COVID-19 Open
View article: Machine Learning Algorithms to Differentiate Among Pulmonary Complications After Hematopoietic Cell Transplant
Machine Learning Algorithms to Differentiate Among Pulmonary Complications After Hematopoietic Cell Transplant Open
View article: Predicting the Incidence of Pressure Ulcers in the Intensive Care Unit Using Machine Learning
Predicting the Incidence of Pressure Ulcers in the Intensive Care Unit Using Machine Learning Open
Background: Reducing hospital-acquired pressure ulcers (PUs) in intensive care units (ICUs) has emerged as an important quality metric for health systems internationally. Limited work has been done to characterize the profile of PUs in the…
View article: Association between Inhaled Corticosteroid Use and Pulmonary Nontuberculous Mycobacterial Infection
Association between Inhaled Corticosteroid Use and Pulmonary Nontuberculous Mycobacterial Infection Open
Inhaled corticosteroid use, and particularly high-dose inhaled corticosteroid use, was associated with an increased risk of NTM pulmonary infection.
View article: Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers
Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers Open
This is the largest study to date reporting the relationship between gender and HVR/ HCVR and the first study assessing the association between genetic polymorphisms in humans and HVR/HCVR. The data suggest that gender has a large effect o…
View article: Extranodal Marginal Zone B Cell Lymphoma of the Lung
Extranodal Marginal Zone B Cell Lymphoma of the Lung Open