Aisha Lateef
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Author Swipe
View article: Predictors of damage accrual by organ domain in systemic lupus erythematosus
Predictors of damage accrual by organ domain in systemic lupus erythematosus Open
Objectives Organ damage in SLE is assessed using the SLICC/ACR Damage Index (SDI), which quantifies damage in 12 organ systems but generally reports a total score. We examined whether the risk factors for overall organ damage accrual captu…
View article: Prevalence, determinants and outcomes of low disease activity and remission attainment in <scp>SLE</scp> patients with clinically active disease
Prevalence, determinants and outcomes of low disease activity and remission attainment in <span>SLE</span> patients with clinically active disease Open
Objectives This study aimed to identify the frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS‐remission) attainment in systemic lupus erythematosus (SLE) patients with clinical…
View article: Family-related quality of life and burden in caregivers of patients with chronic skin diseases
Family-related quality of life and burden in caregivers of patients with chronic skin diseases Open
Background Skin disorders have a significant effect on psychological health, social functioning, and daily activities of patients, which in turn can severely impact their family caregivers’ quality of life. Objectives The goal of our study…
View article: Informing trial measurement in systemic lupus erythematosus: frequency of domain-specific disease activity in a multinational cohort
Informing trial measurement in systemic lupus erythematosus: frequency of domain-specific disease activity in a multinational cohort Open
Objective To report the prevalence of disease activity in individual SLE organ domains, including prevalence stratified by the most common disease activity cut-off score for clinical trial eligibility (SLE Disease Activity Index 2000; SLED…
View article: SEX DIFFERENCES IN SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPREHENSIVE ANALYSIS OF CLINICAL AND TREATMENT DISPARATIES IN A MULTICENTER LONGITUDINAL COHORT
SEX DIFFERENCES IN SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPREHENSIVE ANALYSIS OF CLINICAL AND TREATMENT DISPARATIES IN A MULTICENTER LONGITUDINAL COHORT Open
PV190 / #379 Poster Topic: AS22 - SLE Heterogeneity Background/Purpose Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with female predominance. Due to its lower prevalence in men, SLE is less well understood in male pat…
View article: Frequency and Determinants of Flare and Persistently Active Disease in a Large Multinational Prospective Lupus Cohort
Frequency and Determinants of Flare and Persistently Active Disease in a Large Multinational Prospective Lupus Cohort Open
Objective In contrast to relapsing‐remitting patterns, persistently active disease (PAD) is a disease activity pattern in patients with systemic lupus erythematosus (SLE) that is inadequately studied. We sought to identify the frequency an…
View article: Time trends of variability in disease activity in systemic lupus erythematosus
Time trends of variability in disease activity in systemic lupus erythematosus Open
Objective Disease activity both between and within patients with SLE is highly variable, yet factors driving this variability remain unclear. This study aimed to identify predictors of variability in SLE disease activity over time. Methods…
View article: Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus
Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus Open
Objective To estimate the prevalence of organ damage (damage) and flare and to examine longitudinal associations between flares and subsequent damage accrual, in patients with systemic lupus erythematosus (SLE). Methods Patients enrolled i…
View article: Correlation of Electrocardiogram Derived P Wave Dispersion and Left Ventricular Diastolic Function in Hypertensive Patients
Correlation of Electrocardiogram Derived P Wave Dispersion and Left Ventricular Diastolic Function in Hypertensive Patients Open
Background: Abnormal PWD expressed the impaired atrial electrical conduction which occurs as a result of structural changes (remodelling) in the atria caused by hypertension )HT). Diastolic function of the left ventricle (LV) have signific…
View article: Association of lupus low disease activity state and remission with reduced organ damage and flare in systemic lupus erythematosus patients with high disease activity: a multi-national, longitudinal cohort study
Association of lupus low disease activity state and remission with reduced organ damage and flare in systemic lupus erythematosus patients with high disease activity: a multi-national, longitudinal cohort study Open
Objective High disease activity status (HDAS) in patients with systemic lupus erythematosus (SLE) is associated with adverse long-term outcomes. We examined the frequency of lupus low disease activity state (LLDAS) and remission (REM) atta…
View article: Sub-optimal use of anti-malarial therapy for SLE in the Asia Pacific region: observations from the Asia Pacific lupus cohort
Sub-optimal use of anti-malarial therapy for SLE in the Asia Pacific region: observations from the Asia Pacific lupus cohort Open
Introduction The guidelines for management of patients with systemic lupus erythematosus (SLE) recommend the use of anti-malarial (AM) drugs [commonly hydroxychloroquine (HCQ)] in all patients, unless contraindicated. We evaluated the prev…
View article: Characterisation and outcomes of different subsets of low disease activity states in patients with systemic lupus erythematosus
Characterisation and outcomes of different subsets of low disease activity states in patients with systemic lupus erythematosus Open
Objectives The lupus low disease activity state (LLDAS) allows for certain clinical and/or serological activity of SLE, provided overall disease activity does not exceed predefined cut-offs. This study aimed to evaluate the outcomes of pat…
View article: Association of systemic lupus erythematosus standard of care immunosuppressants with glucocorticoid use and disease outcomes: a multicentre cohort study
Association of systemic lupus erythematosus standard of care immunosuppressants with glucocorticoid use and disease outcomes: a multicentre cohort study Open
Background This study examines the association of standard-of-care systemic lupus erythematosus (SLE) medications with key outcomes such as low disease activity attainment, flares, damage accrual, and steroid-sparing, for which there is cu…
View article: Recommendations for enhanced primary series (third dose) COVID-19 vaccination for people with rheumatic diseases: chapter of Rheumatologists, College of Physicians, Singapore
Recommendations for enhanced primary series (third dose) COVID-19 vaccination for people with rheumatic diseases: chapter of Rheumatologists, College of Physicians, Singapore Open
Introduction: This review aims to provide evidence-based recommendations for an enhanced primary series (third dose) coronavirus disease 2019 (COVID-19) vaccination in people with rheumatic diseases (PRDs) in the local and regional context…
View article: LSO-080 Machine-learning approach on lupus low disease activity prediction
LSO-080 Machine-learning approach on lupus low disease activity prediction Open
Background The development of lupus low disease activity state (LLDAS) as a treat-to-target endpoint for SLE patients has been validated. Its attainment has been associated with improved outcomes. This study aims to show whether a machine …
View article: LSO-087 Sub-optimal use of anti-malarial therapy for SLE in the Asia Pacific region; observations from the Asia Pacific lupus cohort
LSO-087 Sub-optimal use of anti-malarial therapy for SLE in the Asia Pacific region; observations from the Asia Pacific lupus cohort Open
Background The Asia-Pacific League of Associations for Rheumatology (APLAR) recently published consensus recommendations, including overarching principles, general management, and specific treatment strategies for SLE in Asia. The use of h…
View article: LSO-031 Association of serologic and clinical low disease activity states with outcomes in a large multi-national lupus cohort
LSO-031 Association of serologic and clinical low disease activity states with outcomes in a large multi-national lupus cohort Open
Background Lupus Low Disease Activity State (LLDAS) permits serological activity and activity in several organs including joint, muscle, and mucocutaneous activity, provided SLEDA4-2K is <=4 and other LLDAS criteria are met. Methods Patien…
View article: LSO-036 Cluster analysis and subphenotype stratification in lupus erythematosus based on data from the Asia Pacific lupus collaboration cohort (APLC-CASTLE)
LSO-036 Cluster analysis and subphenotype stratification in lupus erythematosus based on data from the Asia Pacific lupus collaboration cohort (APLC-CASTLE) Open
Background Systemic lupus erythematosus (SLE) is a complex disease with heterogenous manifestations.1 Clinical subphenotypes have been reported, but limited studies have evaluated their long-term impact.2 This study utilized the data from …
View article: LO-004 Frequency and determinants of flare and persistently active disease in a large multinational prospective lupus cohort
LO-004 Frequency and determinants of flare and persistently active disease in a large multinational prospective lupus cohort Open
Background The current commonly used definitions of flare may not be able to capture patients with a persistently active disease (PAD) course. This study sought to identity the frequency and determinants of flare and PAD in an Asia-Pacific…
View article: Platelet TLR7 is essential for the formation of platelet–neutrophil complexes and low-density neutrophils in lupus nephritis
Platelet TLR7 is essential for the formation of platelet–neutrophil complexes and low-density neutrophils in lupus nephritis Open
Objectives Platelets and low-density neutrophils (LDNs) are major players in the immunopathogenesis of SLE. Despite evidence showing the importance of platelet–neutrophil complexes (PNCs) in inflammation, little is known about the relation…
View article: SMART-SLE: serology monitoring and repeat testing in systemic lupus erythematosus—an analysis of anti-double-stranded DNA monitoring
SMART-SLE: serology monitoring and repeat testing in systemic lupus erythematosus—an analysis of anti-double-stranded DNA monitoring Open
Objective Disease activity monitoring in SLE includes serial measurement of anti-double stranded-DNA (dsDNA) antibodies, but in patients who are persistently anti-dsDNA positive, the utility of repeated measurement is unclear. We investiga…
View article: Abstracts
Abstracts Open
Aims: Aberrant immune cell activation characterises SLE, in which glucocorticoids (GCs) remain a cornerstone of treatment.However, the unacceptable side effects of GCs have created a pressing need for a similarly broad-acting, but safer, a…
View article: Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With <scp>Long‐Term</scp> Clinical Outcomes: A <scp>Five‐Year</scp> Prospective Study
Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With <span>Long‐Term</span> Clinical Outcomes: A <span>Five‐Year</span> Prospective Study Open
Objective In trials of systemic lupus erythematosus (SLE), the SLE Responder Index (SRI) is the most commonly used primary efficacy end point but has limited validation against long‐term outcomes. We aimed to investigate associations of at…
View article: Impact of teleconsultation on subsequent disease activity and flares in patients with systemic lupus erythematosus
Impact of teleconsultation on subsequent disease activity and flares in patients with systemic lupus erythematosus Open
Objectives Despite the widespread adoption of teleconsultations amid the COVID-19 pandemic, their safety in SLE patients has not been evaluated. Here, we examined subsequent disease activity and flares among SLE patients who received telec…
View article: Recommendations for COVID‐19 vaccination in people with rheumatic disease: Developed by the Singapore Chapter of Rheumatologists
Recommendations for COVID‐19 vaccination in people with rheumatic disease: Developed by the Singapore Chapter of Rheumatologists Open
Aim People with rheumatic diseases (PRD) remain vulnerable in the era of the COVID‐19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS‐CoV‐2 in PRD. Methods Systematic literature …
View article: Recommendations for COVID-19 Vaccination in People with Rheumatic Disease:<i>Developed by the Singapore Chapter of Rheumatologists</i>
Recommendations for COVID-19 Vaccination in People with Rheumatic Disease:<i>Developed by the Singapore Chapter of Rheumatologists</i> Open
Aim People with rheumatic diseases (PRD) remain vulnerable in the era of the COVID-19 pandemic. We formulated recommendations to meet the urgent need for a consensus for vaccination against SARS-CoV-2 in PRD. Methods Systematic literature …