Hussein Hammich
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MiniBAR/KIAA0355 is a dual Rac and Rab effector required for ciliogenesis Open
Cilia protrude from the cell surface and play critical roles in in-tracellular signaling, environmental sensing and development. Actin-dependent contractility and intracellular trafficking are both required for ciliogenesis, but little is …
Structural and functional insights for Rab35 GTPase and its effectors : toward a mechanism for control of actin dynamics in endocytosis and cytokinesis Open
Rab35 is an essential regulator of a recycling pathway back to the plasma membrane, that is also required for the post-furrowing terminal steps during cytokinesis that are associated with F-actin depolymerisation [1]. Rab35 performs its ro…
Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity Open
Rab molecular switches are key players in defining membrane identity and regulating intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity, Rab-family members acquired particular features that …
Oxidation of F-actin controls the terminal steps of cytokinesis Open
Cytokinetic abscission, the terminal step of cell division, crucially depends on the local constriction of ESCRT-III helices after cytoskeleton disassembly. While the microtubules of the intercellular bridge are cut by the ESCRT-associated…