Hussein Mukasa Kafeero
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View article: The epidemiology of hepatitis b virus infection in Uganda after two decades of vaccination: a meta-analysis and meta-regression
The epidemiology of hepatitis b virus infection in Uganda after two decades of vaccination: a meta-analysis and meta-regression Open
View article: Exploring the anticancer potential of R. tridentata extracts: a cytotoxicity study against human prostate cancer cell lines (LNCaP and DU145)
Exploring the anticancer potential of R. tridentata extracts: a cytotoxicity study against human prostate cancer cell lines (LNCaP and DU145) Open
This study investigates the cytotoxic effects of R. tridentata extracts on prostate cancer cells, providing insight into its potential therapeutic benefits and scientific validation for its traditional use in cancer treatment. The cytotoxi…
View article: The status of occult HBV infection in a high endemic region: risk of community HBV transmission and reactivation
The status of occult HBV infection in a high endemic region: risk of community HBV transmission and reactivation Open
View article: Prevalence and predictors of virological failure among the people living with HIV on antiretroviral treatment in East Africa: evidence from a systematic review with meta-analysis and meta-regression of published studies from 2016 to 2023
Prevalence and predictors of virological failure among the people living with HIV on antiretroviral treatment in East Africa: evidence from a systematic review with meta-analysis and meta-regression of published studies from 2016 to 2023 Open
Sociodemographic factors, advanced HIV disease, co-morbidities, poor adherence, and specific first-line ART regimens are key predictors of virological failure. Targeted, multidisciplinary interventions focusing on routine viral load monito…
View article: Building a culture of developing annual health work plan based on data: Critical health system related factors influencing data utilization in Bukedi region, Uganda
Building a culture of developing annual health work plan based on data: Critical health system related factors influencing data utilization in Bukedi region, Uganda Open
Utilization of routine health data for Annual Health Work Plan (AHWP) development is crucial for effective health planning. However, data use remains a challenge in many health facilities, especially in low-resource settings like the Buked…
View article: Enablers and Consequences of Landslide Outbreaks in Bududa District, Eastern Uganda
Enablers and Consequences of Landslide Outbreaks in Bududa District, Eastern Uganda Open
Landslides are rapid movements of rock and soil on the Earth's surface, currently ranked among the most catastrophic environmental disasters worldwide. Bududa district, located on the steep slopes of Mount Elgon in eastern Uganda, has expe…
View article: The Environmental Conservation Strategies Used in Secondary Schools Align with Guidelines of United Nations Environmental Program: Evidence from a Cross-Sectional Study in a City Setting
The Environmental Conservation Strategies Used in Secondary Schools Align with Guidelines of United Nations Environmental Program: Evidence from a Cross-Sectional Study in a City Setting Open
The climate change crisis might soon be the biggest threat to global human existence if immediate action is not taken to overpower it. In Eastern Uganda, Mbale city is among the most affected areas, and the burden manifests in form of disa…
View article: Review of Herbal Medicinal Plants Used in the Management of Cancers in the East Africa Region from 2019 to 2023
Review of Herbal Medicinal Plants Used in the Management of Cancers in the East Africa Region from 2019 to 2023 Open
Background: In the East African region, herbal plants are essential in the treatment and control of cancer. Given the diverse ecological and cultural makeup of the regional states, it is likely that different ethnic groups will use the sam…
View article: Phytocphytochemical Profiles of Rhoicissus Tridentata Harvested From the Slopes of Mountain Elgon, Uganda
Phytocphytochemical Profiles of Rhoicissus Tridentata Harvested From the Slopes of Mountain Elgon, Uganda Open
Introduction: Prostate cancer remains a formidable threat in Uganda. As such, the quest to find novel, efficacious therapies with reduced side effects to avert this challenge is still ongoing. Medicinal plants are taking center stage in th…
View article: A systematic review reveals that African children of 15–17 years demonstrate low hepatitis B vaccine seroprotection rates
A systematic review reveals that African children of 15–17 years demonstrate low hepatitis B vaccine seroprotection rates Open
View article: Medicinal plants used in the management of cancers by residents in the Elgon Sub-Region, Uganda
Medicinal plants used in the management of cancers by residents in the Elgon Sub-Region, Uganda Open
Background In Uganda, medicinal plants have been utilized to treat a variety of ailments, including cancer. However, there is little information available about the medicinal plants used to treat cancer in the Elgon subregion. As a result,…
View article: Phytochemical Profiles of Rhoicissus Tridentata Harvested From the Slopes Elgon Sub-region, Uganda
Phytochemical Profiles of Rhoicissus Tridentata Harvested From the Slopes Elgon Sub-region, Uganda Open
Introduction:Prostate cancer remains a formidable threat in Uganda. As such, the quest to find novel, efficacious therapies with reduced side effects to avert this challenge is still ongoing. Medicinal plants are taking center stage in the…
View article: Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda
Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda Open
Background : In Uganda, medicinal plants have been utilized to treat a variety of ailments, including cancer. The anticancer medicinal herbs employed in the Elgon sub-region, however, have only been the subject of a relatively small number…
View article: The 863C>A and 1031T>C Single Nucleotide Polymorphisms (SNPs) in the Tumor Necrosis Factor Alpha (TNF-α) Promoter Gene May Not Be Putative Predictors of HBV Endemicity
The 863C>A and 1031T>C Single Nucleotide Polymorphisms (SNPs) in the Tumor Necrosis Factor Alpha (TNF-α) Promoter Gene May Not Be Putative Predictors of HBV Endemicity Open
Background: Genetic polymorphisms within the gene loci of the promoter region of tumor necrosis factor (TNF) alpha have been associated with the pathogenesis of hepatitis B virus (HBV) infection. In Uganda, there is a wide variation in the…
View article: Anticancer Medicinal Plants Used by the Natives in the Elgon Sub-region, Eastern Uganda
Anticancer Medicinal Plants Used by the Natives in the Elgon Sub-region, Eastern Uganda Open
Introduction: Medicinal plants have been used to treat several diseases, including cancer in Uganda. However, very few studies have been reported on the anticancer medicinal plants used in the Elgon sub-region. The main aim of this study w…
View article: Mapping hepatitis B virus genotypes on the African continent from 1997 to 2021: a systematic review with meta-analysis
Mapping hepatitis B virus genotypes on the African continent from 1997 to 2021: a systematic review with meta-analysis Open
View article: African children 15 to 17 years of age demonstrate significantly reduced hepatitis B vaccine sero-protection rates: evidence from a systematic review and meta-analysis
African children 15 to 17 years of age demonstrate significantly reduced hepatitis B vaccine sero-protection rates: evidence from a systematic review and meta-analysis Open
Background Childhood HBV immunization remains globally fundamental to the elimination of hepatitis B virus (HBV). However the African paediatric HBV vaccine sero-protection rates and their determinants are crucial to establish; as they rem…
View article: Medically important bacteria isolated from commercial herbal medicines in Kampala city indicate the need to enhance safety frameworks
Medically important bacteria isolated from commercial herbal medicines in Kampala city indicate the need to enhance safety frameworks Open
View article: Mapping Hepatitis B Virus Genotypes, Recombinant Genotypes and Sub- genotypes on the African continent from 1997 to 2021: A Systematic Review with Meta-Analysis
Mapping Hepatitis B Virus Genotypes, Recombinant Genotypes and Sub- genotypes on the African continent from 1997 to 2021: A Systematic Review with Meta-Analysis Open
Hepatitis B virus (HBV) has ten genotypes (A-J) based on the divergence of ≥ 8% in the complete genome. These genotype influence disease prognosis, response to therapy and route of viral transmission. This study aimed at mapping the de nov…
View article: The wild type alleles at positions 857 and 1031 in the Tumor Necrosis Factor gene promoter are highly conserved among the low/high endemic HBV infected persons in Uganda and may not be attributable to disease burden.
The wild type alleles at positions 857 and 1031 in the Tumor Necrosis Factor gene promoter are highly conserved among the low/high endemic HBV infected persons in Uganda and may not be attributable to disease burden. Open
Genetic polymorphisms within the gene loci of the promoter region of tumor necrosis factor (TNF) alpha have been associated with the pathogenesis of hepatitis B virus (HBV) infection. Moreover, the prevalence of these polymorphisms varies …
View article: Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization
Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization Open
The Hepatitis B virus (HBV) is a highly infectious virus and is endemic in Uganda. It is one of the major etiological agents for liver diseases including liver cancer. In this work, we evaluated the prevalence of the HBV serological marker…
View article: TREAT-B Algorithm for Treatment Eligibility Among Chronically Infected Hepatitis B Virus Persons in a Low and a High Endemic Region: A Potential Strategy Towards Virus Elimination by 2030
TREAT-B Algorithm for Treatment Eligibility Among Chronically Infected Hepatitis B Virus Persons in a Low and a High Endemic Region: A Potential Strategy Towards Virus Elimination by 2030 Open
Background Little is known about treatment eligibility in Africa for the hepatitis B virus (TREAT-B) algorithm. We investigated the treatment eligibility among the HBV chronically infected patients in a low and a high endemic region using …
View article: Factors Associated with Condom Use Among Out-of-School Young People on Anti-Retroviral Therapy in Central Uganda
Factors Associated with Condom Use Among Out-of-School Young People on Anti-Retroviral Therapy in Central Uganda Open
Efforts to increase consistent condom use should focus on recruiting more providers in health facilities to intensify condom use sensitization among sexually active young people on ART in the context of HIV epidemic control.
View article: Global evidence on the potential of some Ugandan herbal medicines to mitigate antibiotic resistance: a systematic review and meta-analysis from 1996 to 2021
Global evidence on the potential of some Ugandan herbal medicines to mitigate antibiotic resistance: a systematic review and meta-analysis from 1996 to 2021 Open
Background Diarrheal and respiratory ailments are major causes of global deaths, and are mostly escalated by antibiotic-resistant bacteria (ARB), warranting novel therapies against ARB. In Uganda, plants like C. pyrrhopappa, E. abyssinica,…
View article: Antibiotic-resistance in medically important bacteria isolated from commercial herbal medicines in Africa from 2000 to 2021: a systematic review and meta-analysis
Antibiotic-resistance in medically important bacteria isolated from commercial herbal medicines in Africa from 2000 to 2021: a systematic review and meta-analysis Open
Background Antimicrobial resistance is swiftly increasing all over the world. In Africa, it manifests more in pathogenic bacteria in form of antibiotic resistance (ABR). On this continent, bacterial contamination of commonly used herbal me…
View article: Disproportionate Distribution of HBV Genotypes A and D and the Recombinant Genotype D/E in the High and Low HBV Endemic Regions of Uganda: A Wake-Up Call for Regional Specific HBV Management
Disproportionate Distribution of HBV Genotypes A and D and the Recombinant Genotype D/E in the High and Low HBV Endemic Regions of Uganda: A Wake-Up Call for Regional Specific HBV Management Open
Background. Hepatitis B virus (HBV) is the leading cause of liver-related diseases. In Uganda, there is a regional disparity in the HBV burden. Our study was aimed at establishing the circulating genotypes in a low and a high endemic regio…
View article: Assessment of Knowledge, Perception, Attitude, Risk Factors Prevention, and Treatment Options of Cancer among Natives in Elgon Sub-Region, Uganda
Assessment of Knowledge, Perception, Attitude, Risk Factors Prevention, and Treatment Options of Cancer among Natives in Elgon Sub-Region, Uganda Open
Background: Globally, cancer is one of the leading causes of morbidity and mortality and most cancers are due to infections and so, are preventable. Earlier studies revealed that several cancers could be preventable through intensified hea…
View article: Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region
Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region Open
Background: Cancer is one of the serious health burdens in the 21st century with a steady rise in cases and deaths. The current interventions used in cancer management are chemotherapy, radiation, and surgery, but are ineffective, and also…
View article: Prevalence and predictors of hepatitis B virus (HBV) infection in east Africa: evidence from a systematic review and meta-analysis of epidemiological studies published from 2005 to 2020
Prevalence and predictors of hepatitis B virus (HBV) infection in east Africa: evidence from a systematic review and meta-analysis of epidemiological studies published from 2005 to 2020 Open
View article: Family Planning Utilization among PLWHIV Attending TASO Masaka: Evidence from a Cross-Sectional Study
Family Planning Utilization among PLWHIV Attending TASO Masaka: Evidence from a Cross-Sectional Study Open
People living with HIV (PLWHIV) need family planning (FP) services to avert the spread of HIV and eliminate mother to child transmission (MTCT). Besides, family planning services greatly reduce the incidence of vertical transmission reduci…