Huxia Wang
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View article: The reduced DLG5 promotes doxorubicin resistance in breast cancer cells MCF-7 through regulating autophagy
The reduced DLG5 promotes doxorubicin resistance in breast cancer cells MCF-7 through regulating autophagy Open
Breast cancer is among the most prevalent malignant tumors in women globally, with adriamycin (ADM) demonstrating considerable efficacy as a first-line chemotherapeutic agent. The problem of adriamycin resistance significantly impairs its …
View article: Identification of hub genes for the diagnosis and prognosis in triple negative breast cancer using transcriptome and differential methylation integration analysis
Identification of hub genes for the diagnosis and prognosis in triple negative breast cancer using transcriptome and differential methylation integration analysis Open
Introduction: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It is highly invasive and aggr…
View article: Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer
Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer Open
View article: Identifying the mechanism of polysaccharopeptide against breast cancer based on network pharmacology and experimental verification
Identifying the mechanism of polysaccharopeptide against breast cancer based on network pharmacology and experimental verification Open
View article: Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer
Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer Open
Background: Energy metabolism has a complex intersection with pathogenesis and development of breast cancer (BC). This allows for the possibility of identifying energy-metabolism-related genes (EMRGs) as novel prognostic biomarkers for BC.…
View article: Targeted RASSF1A expression inhibits proliferation of HER2‑positive breast cancer cells <i>in vitro</i>
Targeted RASSF1A expression inhibits proliferation of HER2‑positive breast cancer cells <i>in vitro</i> Open
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer, which accounts for 15-20% of all breast cancer, is associated with tumor recurrence and poor prognosis. RAS association domain family protein 1 subtype A (RASSF1A) is…
View article: Metformin and simvastatin synergistically suppress endothelin 1‐induced hypoxia and angiogenesis in multiple cancer types
Metformin and simvastatin synergistically suppress endothelin 1‐induced hypoxia and angiogenesis in multiple cancer types Open
Multiple cancers have been reported to be associated with angiogenesis and are sensitive to anti‐angiogenic therapies. Vascular normalization, by restoring proper tumor perfusion and oxygenation, could limit tumor cell invasiveness and imp…
View article: Establishment and verification of a nomogram for predicting survival in patients with triple-positive breast cancer
Establishment and verification of a nomogram for predicting survival in patients with triple-positive breast cancer Open
The prediction model accurately predicted the prognosis of and identified high-risk TPBC patients.
View article: Development and Validation of a 6-Gene Hypoxia-Related Prognostic Signature For Cholangiocarcinoma
Development and Validation of a 6-Gene Hypoxia-Related Prognostic Signature For Cholangiocarcinoma Open
Cholangiocarcinoma (CHOL) is highly malignant and has a poor prognosis. This study is committed to creating a new prognostic model based on hypoxia related genes. Here, we established a novel tumor hypoxia-related prognostic model consisti…
View article: A Crucial Angiogenesis-Associated Gene MEOX2 Could Be a Promising Biomarker Candidate for Breast Cancer
A Crucial Angiogenesis-Associated Gene MEOX2 Could Be a Promising Biomarker Candidate for Breast Cancer Open
Background Angiogenesis plays a critical role in the growth and metastasis of breast cancer and angiogenesis inhibition has become an effective strategy for cancer therapy. Our study aimed to clarify the key candidate genes and pathways re…
View article: Consistency Analysis of CTLM Imaging and Mammography in the Diagnosis of Breast Tumor Lesions
Consistency Analysis of CTLM Imaging and Mammography in the Diagnosis of Breast Tumor Lesions Open
Objective. To analyze the consistency of preoperative CTLM imaging in the diagnosis of breast cancer lesions and postoperative pathological examination. Methods. The clinical data of 225 patients with breast tumor in our breast surgery dep…
View article: The Low Expression of MEOX2 is Associated With Poorer Survival in Breast Cancer
The Low Expression of MEOX2 is Associated With Poorer Survival in Breast Cancer Open
The regulation of vertebrate limb myogenesis gene, Mesenchyme Homeobox 2 (MEOX2), has been reported to be associated with most cancer progression closely. However, its role and function in breast cancer are unidentified. Here, we aim to in…
View article: Dynamic Nomogram Predicts Overall Survival in Patients With Occult Breast Cancer: a Population-based Analysis
Dynamic Nomogram Predicts Overall Survival in Patients With Occult Breast Cancer: a Population-based Analysis Open
Background: Due the rarity of occult breast cancer (OBC), no precise prognostic instruments were available to assess the overall survival (OS) in patients with OBC. The aim of this study is to construct a nomogram for predicting the OS pro…
View article: Effective Suppression of Hypoxia Induced Angiogenesis by Synergism of Simvastatin and Metformin via Inhibiting ET-1-ETBR-Hif1α Signaling Axis
Effective Suppression of Hypoxia Induced Angiogenesis by Synergism of Simvastatin and Metformin via Inhibiting ET-1-ETBR-Hif1α Signaling Axis Open
Background: Hypoxic stress accelerates metabolic reprogramming to promote malignant progression, which contains huge and interesting drug targets for cancer therapy. According to recently reports and our previously researches, simvastatin …
View article: Exosomal MiR-744 Inhibits Proliferation and Sorafenib Chemoresistance in Hepatocellular Carcinoma by Targeting PAX2
Exosomal MiR-744 Inhibits Proliferation and Sorafenib Chemoresistance in Hepatocellular Carcinoma by Targeting PAX2 Open
BACKGROUND Hepatocellular carcinoma (HCC) is a commonly occurring liver malignancy. Its prognosis remains unsatisfactory. Accumulating evidence has revealed that exosomal microRNAs (miRNAs) act as biomarkers and play crucial roles in the a…