Hwei Ling Ong
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View article: Copeptin - a long-ignored peptide hormone
Copeptin - a long-ignored peptide hormone Open
Arginine vasopressin (AVP), the antidiuretic hormone secreted by hypothalamic neurons, controls water resorption and blood pressure via its receptors in the kidney and vasculature, respectively. We demonstrated and published earlier that A…
View article: A Deep Dive into the N-Terminus of STIM Proteins: Structure–Function Analysis and Evolutionary Significance of the Functional Domains
A Deep Dive into the N-Terminus of STIM Proteins: Structure–Function Analysis and Evolutionary Significance of the Functional Domains Open
Calcium is an important second messenger that is involved in almost all cellular processes. Disruptions in the regulation of intracellular Ca2+ levels ([Ca2+]i) adversely impact normal physiological function and can contribute to various d…
View article: Essential role of N-terminal SAM regions in STIM1 multimerization and function
Essential role of N-terminal SAM regions in STIM1 multimerization and function Open
The single-pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the endoplasmic reticulum (ER) membrane, possesses two main functions: It senses the ER-Ca 2+ concentration and directly binds to the store-operated C…
View article: STIM Proteins and Regulation of SOCE in ER-PM Junctions
STIM Proteins and Regulation of SOCE in ER-PM Junctions Open
ER-PM junctions are membrane contact sites formed by the endoplasmic reticulum (ER) and plasma membrane (PM) in close apposition together. The formation and stability of these junctions are dependent on constitutive and dynamic enrichment …
View article: Functional communication between IP <sub>3</sub> R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE
Functional communication between IP <sub>3</sub> R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE Open
Significance STIM proteins sense decreases in [Ca 2+ ] ER and cluster in endoplasmic reticulum (ER)–plasma membrane (PM) junctions where they recruit and activate Orai1. While STIM1 clustering requires substantial [Ca 2+ ] ER decrease, STI…
View article: Functional Communication between IP<sub>3</sub>R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE
Functional Communication between IP<sub>3</sub>R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE Open
Stromal interaction molecules, STIM1 and STIM2, sense decreases in the endoplasmic reticulum (ER) [Ca 2+ ] ([Ca 2+ ] ER ) and cluster in ER-plasma membrane (ER-PM) junctions where they recruit and activate Orai1. While STIM1 responds when …
View article: RACK1 plays a critical role in mast cell secretion and Ca2+ mobilization by modulating F-actin dynamics
RACK1 plays a critical role in mast cell secretion and Ca2+ mobilization by modulating F-actin dynamics Open
Although RACK1 is known to act as a signaling hub in immune cells, its presence and role in mast cells (MCs) is undetermined. MC activation via antigen stimulation results in mediator release and is preceded by cytoskeleton reorganization …
View article: STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca <sup>2+</sup> entry with NFAT1 activation
STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca <sup>2+</sup> entry with NFAT1 activation Open
Significance Ca 2+ entry mediated by the plasma membrane (PM) channel Orai1 controls nuclear factor of activated T cells 1 (NFAT1)-dependent gene expression that regulates critical cellular functions. Ca 2+ -sensing endoplasmic reticulum (…
View article: TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes
TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes Open
Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals. Here, we report that TRIC-A-mediated amplitude and frequency modulation o…
View article: The Endoplasmic Reticulum–Plasma Membrane Junction: A Hub for Agonist Regulation of Ca<sup>2+</sup> Entry
The Endoplasmic Reticulum–Plasma Membrane Junction: A Hub for Agonist Regulation of Ca<sup>2+</sup> Entry Open
Stimulation of cell-surface receptors induces cytosolic Ca2+ ([Ca2+]i) increases that are detected and transduced by effector proteins for regulation of cell function. Intracellular Ca2+ release, via endoplasmic reticulum (ER) proteins ino…
View article: TRP Channel Involvement in Salivary Glands—Some Good, Some Bad
TRP Channel Involvement in Salivary Glands—Some Good, Some Bad Open
Salivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely important role in the maintenance of oral health. Loss of salivary secretion causes a dry mouth condition, xerostomia, which has numerous deleteriou…
View article: STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions
STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions Open
Ca2+ entry mediated by the calcium channel, Orai1, provides critical Ca2+ signals that regulate cell function. The ER-Ca2+ sensor protein, STIM1, recruits and strongly activates Orai1 within ER-PM junctions. STIM2 is a poor activator of Or…
View article: Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway
Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway Open
Radiation for head and neck cancers causes dry mouth by suppressing store-operated Ca 2+ entry in salivary glands.
View article: Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells
Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells Open
The signaling pathways involved in the generation and maintenance of exocrine gland acinar cells have not yet been established. Primary human salivary gland epithelial cells, derived from salivary gland biopsies, acquired an acinar-like ph…