Ernest Hung Yu Ng
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View article: Maternal causation of early-onset pre-eclampsia: excessive endometrial gland-derived apolipoprotein D induces placental ferroptosis and developmental abnormalities
Maternal causation of early-onset pre-eclampsia: excessive endometrial gland-derived apolipoprotein D induces placental ferroptosis and developmental abnormalities Open
View article: Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration
Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration Open
The extracellular matrix (ECM) constantly remodels to tailor a temporal spatial specific environment for the residing cells to respond to physiological or pathological stimuli. Endometrial mesenchymal stem cells (eMSC) are excellent therap…
View article: Randomized controlled study on the use of virtual reality for pain relief in oocyte retrieval under transvaginal ultrasound guidance using paracervical block and conscious sedation
Randomized controlled study on the use of virtual reality for pain relief in oocyte retrieval under transvaginal ultrasound guidance using paracervical block and conscious sedation Open
STUDY QUESTION Does the use of virtual reality (VR) reduce pain levels experienced by women during transvaginal oocyte retrieval using paracervical block and conscious sedation? SUMMARY ANSWER The use of VR did not reduce pain levels durin…
View article: A call for interdisciplinary bereavement care in miscarriage and stillbirth: a stepped-care model approach
A call for interdisciplinary bereavement care in miscarriage and stillbirth: a stepped-care model approach Open
View article: The efficacy of an ovarian stimulation regimen should be based on randomized trials
The efficacy of an ovarian stimulation regimen should be based on randomized trials Open
View article: Effect of freezing and storage on serum vitamin D levels measured by mass spectrometry and immunoassay in reproductive age women
Effect of freezing and storage on serum vitamin D levels measured by mass spectrometry and immunoassay in reproductive age women Open
The objective of this study was to assess the effects of freezing and storage on serum vitamin D levels in women undergoing ovarian stimulation for in vitro fertilization and in the natural cycle. This is a prospective observational in vit…
View article: Chinese Herbal medicine (new “Shoutai Wan”) and/or Oral Progesterone Intervention Trial for threatened miscarriage (CHOP-IT): study protocol of a randomized controlled trial
Chinese Herbal medicine (new “Shoutai Wan”) and/or Oral Progesterone Intervention Trial for threatened miscarriage (CHOP-IT): study protocol of a randomized controlled trial Open
View article: The ITE House Cup: A Game-Changing Approach to Resident Board Preparation
The ITE House Cup: A Game-Changing Approach to Resident Board Preparation Open
View article: Myometrial extracellular vesicles promoted endometrial mesenchymal stem/stromal cells to self-renewal via jag1-mediated notch signaling
Myometrial extracellular vesicles promoted endometrial mesenchymal stem/stromal cells to self-renewal via jag1-mediated notch signaling Open
View article: O-243 Comparing the euploidy rate between the progestin-primed and gonadotrophin-releasing hormone antagonist protocols in preimplantation genetic testing for aneuploidy: a randomized controlled trial
O-243 Comparing the euploidy rate between the progestin-primed and gonadotrophin-releasing hormone antagonist protocols in preimplantation genetic testing for aneuploidy: a randomized controlled trial Open
Study question To compare the euploidy rate between the progestin-primed ovarian stimulation (PPOS) and gonadotrophin-releasing hormone (GnRH) antagonist protocols in preimplantation genetic testing for aneuploidy (PGT-A). Summary answer T…
View article: O-131 Validating the use of multiples of the median (MoM) of serum anti-Mullerian hormone (AMH) levels for diagnosing polycystic ovary syndrome
O-131 Validating the use of multiples of the median (MoM) of serum anti-Mullerian hormone (AMH) levels for diagnosing polycystic ovary syndrome Open
Study question How does MoM AMH perform as a surrogate of polycystic ovary morphology (PCOM) in diagnosing polycystic ovary syndrome (PCOS) among anovulatory women? Summary answer Age-specific MoM-AMH is a good surrogate biomarker to defin…
View article: Planned oocyte cryopreservation in Hong Kong: a potential prototype for mainland China
Planned oocyte cryopreservation in Hong Kong: a potential prototype for mainland China Open
The advent of planned oocyte cryopreservation (planned OC) represents a pivotal transition from reactive infertility treatments to proactive fertility preservation, providing a contemporary solution for women aiming to synchronise their ca…
View article: Comparison of the euploidy rate in preimplantation genetic testing for aneuploidy cycles following progestin-primed versus gonadotropin-releasing hormone antagonist protocol: a randomized controlled study
Comparison of the euploidy rate in preimplantation genetic testing for aneuploidy cycles following progestin-primed versus gonadotropin-releasing hormone antagonist protocol: a randomized controlled study Open
gov/ ). Trial registration date: Clinicaltrials. gov: 30 July 2021.
View article: A core outcome set for future male infertility research: development of an international consensus
A core outcome set for future male infertility research: development of an international consensus Open
STUDY QUESTION Can a core outcome set be developed through a global consensus to standardize outcome selection, collection, comparison, and reporting in future male infertility trials? SUMMARY ANSWER A minimum dataset, known as a ‘core out…
View article: Comparison of precision of a paperless electronic input method versus the conventional paper form in an andrology laboratory: a prospective study
Comparison of precision of a paperless electronic input method versus the conventional paper form in an andrology laboratory: a prospective study Open
Background Manual counting for semen analysis is recommended by the World Health Organization. Technicians performing this usually record their results on a paper worksheet and then enter the data into an electronic laboratory information …
View article: Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis
Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis Open
HKUCTR 2361 (9th March 2018).
View article: Association of serum vitamin D level and live birth rate in women undergoing frozen embryo transfer—a retrospective cohort study
Association of serum vitamin D level and live birth rate in women undergoing frozen embryo transfer—a retrospective cohort study Open
Purpose To assess the association of serum vitamin D level and the live birth rate in women undergoing frozen embryo transfer (FET). Methods This is a retrospective cohort study involving 1489 infertile women who had frozen embryo transfer…
View article: Automatic identification of human spermatozoa with zona pellucida-binding capability using deep learning
Automatic identification of human spermatozoa with zona pellucida-binding capability using deep learning Open
STUDY QUESTION Can a deep-learning algorithm, independent of World Health Organization (WHO) sperm morphology grading, be used to identify human spermatozoa with zona pellucida (ZP)-binding capability in assisted reproductive technology (A…
View article: Public fertility preservation programme for cancer patients in Hong Kong
Public fertility preservation programme for cancer patients in Hong Kong Open
Since the establishment of a public FP programme for cancer patients, there has been an increase in the demand for FP services at our centre. Regular review of FP services is warranted to assess changes in demand and identify areas for imp…
View article: Levonorgestrel at emergency contraception dose has no effect on ciliary beat frequency and muscular contraction of the human fallopian tube: an in vitro experimental study
Levonorgestrel at emergency contraception dose has no effect on ciliary beat frequency and muscular contraction of the human fallopian tube: an in vitro experimental study Open
View article: Combined inhibition of histone methyltransferases <scp>EZH2</scp> and <scp>DOT1L</scp> is an effective therapy for neuroblastoma
Combined inhibition of histone methyltransferases <span>EZH2</span> and <span>DOT1L</span> is an effective therapy for neuroblastoma Open
Background The child cancer, neuroblastoma (NB), is characterised by a low incidence of mutations and strong oncogenic embryonal driver signals. Many new targeted epigenetic modifier drugs have failed in human trials as monotherapy. Method…
View article: Context-Specific Resilience Through a Cultural Lens: Social-Ecological Factors Among Chinese Families of Children with Neurodevelopmental Disabilities
Context-Specific Resilience Through a Cultural Lens: Social-Ecological Factors Among Chinese Families of Children with Neurodevelopmental Disabilities Open
With the rise in attention towards Neurodevelopmental Disorders in Hong Kong and worldwide, understanding the role of social ecological resilience in reducing parenting stress and enhancing child outcomes is crucial, particularly within th…
View article: B cells: roles in physiology and pathology of pregnancy
B cells: roles in physiology and pathology of pregnancy Open
B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well as the associated molecular pathways, has yet t…
View article: Comparison of the euploidy rate in preimplantation genetic testing for aneuploidy cycles following progestin-primed versus gonadotropin-releasing hormone antagonist protocol: a randomized controlled study
Comparison of the euploidy rate in preimplantation genetic testing for aneuploidy cycles following progestin-primed versus gonadotropin-releasing hormone antagonist protocol: a randomized controlled study Open
Background Progestins can block endogenous luteinizing hormone secretion from the pituitary gland and have shown similar efficacy in terms of collecting competent oocytes and embryos; however, some inconsistencies have been proposed by the…
View article: Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway
Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway Open
Background At menstruation, the functional layer of the human endometrium sheds off due to the trigger of the release of inflammatory factors, including interleukin 6 (IL-6), as a result of a sharp decline in progesterone levels, leading t…
View article: Immediate versus delayed single blastocyst transfer following the first stimulated IVF cycle in the freeze-all strategy: a study protocol for a randomised controlled trial
Immediate versus delayed single blastocyst transfer following the first stimulated IVF cycle in the freeze-all strategy: a study protocol for a randomised controlled trial Open
Introduction In recent years, the use of frozen embryo transfers (FET) has rapidly increased following the freeze-all strategy due to the advantages of increased maternal safety, improved pregnancy rates, lower ectopic pregnancy rates and …
View article: Effect of vitamin D in addition to letrozole on the ovulation rate of women with polycystic ovary syndrome: protocol of a multicentre randomised double-blind controlled trial
Effect of vitamin D in addition to letrozole on the ovulation rate of women with polycystic ovary syndrome: protocol of a multicentre randomised double-blind controlled trial Open
Introduction Low vitamin D status is prevalent among women with polycystic ovary syndrome (PCOS). The objective of the study is to assess the effect of vitamin D supplementation on (1) the ovulation rate to letrozole and (2) other reproduc…
View article: Comparison of the multiples of the median of serum anti‐müllerian hormone and pregnancy outcomes in patients with gestational trophoblastic disease: A case–control study
Comparison of the multiples of the median of serum anti‐müllerian hormone and pregnancy outcomes in patients with gestational trophoblastic disease: A case–control study Open
Introduction Chemotherapy is crucial in treating gestational trophoblastic neoplasia (GTN), but its impact on gonadotoxicity is unclear. Materials and Methods This case–control study included 57 GTN patients and 19 age‐matched patients wit…
View article: Correction to: Optimizing non‑invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non‑invasive PGT‑A results
Correction to: Optimizing non‑invasive preimplantation genetic testing: investigating culture conditions, sample collection, and IVF treatment for improved non‑invasive PGT‑A results Open
View article: Comparing blastocyst euploid rates between the progestin-primed and gonadotrophin-releasing hormone antagonist protocols in aneuploidy genetic testing: a randomised trial protocol
Comparing blastocyst euploid rates between the progestin-primed and gonadotrophin-releasing hormone antagonist protocols in aneuploidy genetic testing: a randomised trial protocol Open
Introduction Progestin can inhibit the pituitary luteinising hormone (LH) surge during ovarian stimulation for in vitro fertilisation (IVF) and studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge …