Helen Kim
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View article: Measuring the Dynamic Efficiency of the Regional R&D Investment Using a Global Malmquist Productivity Index
Measuring the Dynamic Efficiency of the Regional R&D Investment Using a Global Malmquist Productivity Index Open
View article: Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations
Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations Open
Importance Annual rates of first intracranial hemorrhage (ICH) from unruptured brain arteriovenous malformations (AVMs) are often quoted as 2% to 4% in clinical practice. Precise estimates and risk factors are unavailable to inform treatme…
View article: A Case of Godtfredsen Syndrome due to Nasopharyngeal Cancer Presenting as Sixth and Twelfth Nerve Palsies
A Case of Godtfredsen Syndrome due to Nasopharyngeal Cancer Presenting as Sixth and Twelfth Nerve Palsies Open
Purpose: We present a case of Godtfredsen syndrome, characterized by concurrent sixth and twelfth cranial nerve palsies, in a patient with nasopharyngeal cancer.Case summary: A 74-year-old male with diplopia and headache with a duration of…
View article: Association of Quality of Life Domains and Clinical Symptoms in Patients With Familial Cerebral Cavernous Malformation
Association of Quality of Life Domains and Clinical Symptoms in Patients With Familial Cerebral Cavernous Malformation Open
Background Familial cerebral cavernous malformation (fCCM) is characterized by multiple brain lesions affecting quality of life. PROMIS‐29 (Patient‐Reported Outcomes Measurement Information System 29) is a quality of life survey validated …
View article: Assessing racial differences in North American hereditary hemorrhagic telangiectasia study recruitment and care
Assessing racial differences in North American hereditary hemorrhagic telangiectasia study recruitment and care Open
Background There is increasing evidence of health outcome disparities due to inequitable healthcare. These inequities are likely compounded in rare disease care and research. We aimed to identify disparities in access to clinical care and …
View article: Common and distinct circulating microRNAs in four neurovascular disorders
Common and distinct circulating microRNAs in four neurovascular disorders Open
View article: 4D flow MRI for noninvasive monitoring of high-flow vascular malformations in neonates and infants: A feasibility study
4D flow MRI for noninvasive monitoring of high-flow vascular malformations in neonates and infants: A feasibility study Open
Background Intracranial high-flow vascular malformations greatly alter neonatal cerebral hemodynamics and can cause significant morbidity and mortality. X-ray digital subtraction angiography (DSA) is the standard of care to assess angioarc…
View article: Lifetime Risk of First Symptomatic ICH or Seizure in Familial Cerebral Cavernous Malformations
Lifetime Risk of First Symptomatic ICH or Seizure in Familial Cerebral Cavernous Malformations Open
The event rate of SH and seizures remained stable over time, leading to high cumulative lifetime risks. Patients with CCM3 variations exhibited a more aggressive disease course. Limitations include the non-population-based design, s…
View article: Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel
Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel Open
BACKGROUND AND OBJECTIVES: Despite many publications about cavernous malformations (CMs), controversy remains regarding diagnostic and management strategies. To update evidence-based guidelines for the clinical management of brain and spin…
View article: Somatic mutations in arteriovenous malformations in hereditary hemorrhagic telangiectasia support a bi-allelic two-hit mutation mechanism of pathogenesis
Somatic mutations in arteriovenous malformations in hereditary hemorrhagic telangiectasia support a bi-allelic two-hit mutation mechanism of pathogenesis Open
View article: Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study
Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study Open
Background Symptomatic cerebral cavernous malformations are a rare sporadic or familial disease, which may cause haemorrhagic strokes or epileptic seizures. In 2015, a James Lind Alliance Priority Setting Partnership ranked targeted drug t…
View article: Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance
Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance Open
View article: Corrigendum to “Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance” [Journal of Cardiovascular Magnetic Resonance 27 (2025) 101840]
Corrigendum to “Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance” [Journal of Cardiovascular Magnetic Resonance 27 (2025) 101840] Open
View article: Brain and lung arteriovenous malformation rescreening practices for children and adults with hereditary hemorrhagic telangiectasia
Brain and lung arteriovenous malformation rescreening practices for children and adults with hereditary hemorrhagic telangiectasia Open
Background Patients with hereditary hemorrhagic telangiectasia (HHT) are at risk for organ vascular malformations including arteriovenous malformations (AVMs) in the brain and lungs. North American HHT Centers of Excellence (CoEs) routinel…
View article: <i>Chandra</i> Survey in the AKARI deep field at the North Ecliptic Pole
<i>Chandra</i> Survey in the AKARI deep field at the North Ecliptic Pole Open
Aims. We present a catalog of optical and infrared (NIR) identifications (ID) of X-ray sources in the AKARI North Ecliptic Pole (NEP) deep field detected with Chandra, covering ~0.34 deg 2 and with 0.5–2 keV flux limits ranging between ~2–…
View article: Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling
Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling Open
BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities in patients, suggests that environmental, genetic, or biological fa…
View article: De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia
De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia Open
View article: Current and Future Treatment Options for Cerebral Cavernous Malformations
Current and Future Treatment Options for Cerebral Cavernous Malformations Open
Cerebral cavernous malformations (CCMs) are vascular lesions associated with seizures, hemorrhage, and neurologic deficits. The familial form of CCM constitutes ≈20% of cases and presents with multifocal lesions in the brain and spinal cor…
View article: Developmental uterine anomalies in transgender patients receiving gender-affirming hysterectomies
Developmental uterine anomalies in transgender patients receiving gender-affirming hysterectomies Open
View article: (261) Vasovasostomy Surgical Simulation Using En Bloc Orchiectomy Specimen
(261) Vasovasostomy Surgical Simulation Using En Bloc Orchiectomy Specimen Open
Introduction Surgical simulation with use of synthetic materials, animals, or human tissues is an essential part of surgical training. Prior vasovasostomy (VV) simulations have described use of silicone tubules, animal vasa, and vas segmen…
View article: Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations
Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations Open
Cerebral cavernous malformations (CCMs) are vascular lesions characterized by a porous endothelium. The lack of a sufficient endothelial barrier can result in microbleeds and frank intracerebral hemorrhage. A primary mechanism for lesion d…
View article: P209 Work productivity and unmet needs of treated ulcerative colitis patients: A Japan National Health and Wellness Survey study
P209 Work productivity and unmet needs of treated ulcerative colitis patients: A Japan National Health and Wellness Survey study Open
Background Ulcerative colitis (UC), a subset of inflammatory bowel disease (IBD), is a chronic, immune-mediated disease process which causes inflammation and ulceration of the large intestine. In Japan, the annual prevalence of UC in 2014 …
View article: Best Abstract: Lifetime risk for a first ICH or seizure in patients with Familial cErebral cavernous mal-formations (LIFE): A multicenter international pooled patient data analysis
Best Abstract: Lifetime risk for a first ICH or seizure in patients with Familial cErebral cavernous mal-formations (LIFE): A multicenter international pooled patient data analysis Open
View article: Lifetime Risk for a First Symptomatic ICH or Seizure in Patients with Familial Cerebral Cavernous Malformations (LIFE): A Multicentre Individual Patient Data Analysis
Lifetime Risk for a First Symptomatic ICH or Seizure in Patients with Familial Cerebral Cavernous Malformations (LIFE): A Multicentre Individual Patient Data Analysis Open
View article: Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse
Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse Open
Background: The increase in the collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow and pressure changes. Activated microglia enhance inflammation-induced fibrosis. Hypotheses: T…
View article: Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome
Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome Open
BACKGROUND: Cerebral cavernous malformation with symptomatic hemorrhage (SH) are targets for novel therapies. A multisite trial-readiness project ( https://www.clinicaltrials.gov ; Unique identifier: NCT03652181) aimed to identify clinical…
View article: Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling
Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling Open
BACKGROUND: Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new…
View article: Increased Collagen I/ Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse
Increased Collagen I/ Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse Open
Background: Increase of collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow and pressure changes. We hypothesized that COL I/COL III ratio is increased in the brain arteriovenous…
View article: Reply to Eker et al. Comment on “Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704”
Reply to Eker et al. Comment on “Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704” Open
We are grateful to Eker et al. for their thoughtful analysis and response to our publication titled Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT [...]
View article: EP02.47: Immersive virtual reality simulation training for Caesarean section: a randomised controlled trial
EP02.47: Immersive virtual reality simulation training for Caesarean section: a randomised controlled trial Open
Caesarean section (CS) is a complex surgical procedure that involves many steps and requires careful precision. Virtual reality (VR) simulation has emerged as a promising tool for medical education and training, providing a realistic and i…