Hyebin Lee
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View article: Changes in Incidental Paranasal Sinus Abnormalities During the COVID-19 Era: A 5-Year MRI-Based Study
Changes in Incidental Paranasal Sinus Abnormalities During the COVID-19 Era: A 5-Year MRI-Based Study Open
Background and Objectives: The coronavirus disease 2019 (COVID-19) pandemic and associated nonpharmaceutical interventions, including mask-wearing and hand hygiene, have led to a global decline in otorhinolaryngologic conditions, with the …
View article: Integrating surface‐guided radiation therapy and continuous positive airway pressure for breast cancer: Improving reproducibility and efficacy
Integrating surface‐guided radiation therapy and continuous positive airway pressure for breast cancer: Improving reproducibility and efficacy Open
Background The utility of surface‐guided radiation therapy (SGRT) with continuous positive airway pressure (CPAP) remains underexplored compared to its application with deep inspiratory breath hold (DIBH). This study investigates the integ…
View article: MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer Open
Background Resistance to chemotherapy remains a major clinical challenge in triple-negative breast cancer (TNBC), an intrinsic subtype with limited available therapeutic options. The expression of moesin (MSN) is upregulated in TNBC patien…
View article: Evaluation of Modified Fasting Protocols to Shorten Fasting Time Before Sedation in Children: A Prospective Randomized Noninferiority Trial
Evaluation of Modified Fasting Protocols to Shorten Fasting Time Before Sedation in Children: A Prospective Randomized Noninferiority Trial Open
Backgrounds Guidelines for fasting before procedural sedation aim to prevent pulmonary aspiration and are primarily targeted for deep sedation. Our study explored whether a shortened fasting protocol is noninferior to the standard protocol…
View article: Non-Operative Management of Rectal Cancer with Adjuvant Chemotherapy after Chemoradiotherapy (NORMANDY): Prospective Study
Non-Operative Management of Rectal Cancer with Adjuvant Chemotherapy after Chemoradiotherapy (NORMANDY): Prospective Study Open
NOM with adjuvant capecitabine showed promising oncological outcomes, offering an alternative to passive watch-and-wait approaches. Further refinement through multidisciplinary strategies is warranted.
View article: Discovery of the therapeutic potential of naltriben against glutamate-induced neurotoxicity
Discovery of the therapeutic potential of naltriben against glutamate-induced neurotoxicity Open
Glutamate-induced neuronal death is associated with neurodegeneration including cerebral ischemia. Several μ-opioid receptor antagonists exhibit a neuroprotective activity and have been considered as a potential therapeutic option for neur…
View article: Deep learning-based classification system of bacterial keratitis and fungal keratitis using anterior segment images
Deep learning-based classification system of bacterial keratitis and fungal keratitis using anterior segment images Open
Introduction Infectious keratitis is a vision threatening disease. Bacterial and fungal keratitis are often confused in the early stages, so right diagnosis and optimized treatment for causative organisms is crucial. Antibacterial and anti…
View article: Evaluation of Pretreatment Albumin–Bilirubin Grade as a Better Prognostic Factor Compared to Child–Pugh Classification in Patients with Hepatocellular Carcinoma Receiving Transarterial Chemoembolization Combined with Radiotherapy
Evaluation of Pretreatment Albumin–Bilirubin Grade as a Better Prognostic Factor Compared to Child–Pugh Classification in Patients with Hepatocellular Carcinoma Receiving Transarterial Chemoembolization Combined with Radiotherapy Open
This study assessed the use of pretreatment albumin–-bilirubin (ALBI) grade as a prognostic factor in patients with hepatocellular carcinoma (HCC) receiving combined transarterial chemoembolization (TACE) and radiotherapy (RT). Patients wh…
View article: Big data and artificial intelligence in ophthalmology - clinical application and future exploration
Big data and artificial intelligence in ophthalmology - clinical application and future exploration Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: Dual Oxidase 2 (DUOX2) as a Proteomic Biomarker for Predicting Treatment Response to Chemoradiation Therapy for Locally Advanced Rectal Cancer: Using High-Throughput Proteomic Analysis and Machine Learning Algorithm
Dual Oxidase 2 (DUOX2) as a Proteomic Biomarker for Predicting Treatment Response to Chemoradiation Therapy for Locally Advanced Rectal Cancer: Using High-Throughput Proteomic Analysis and Machine Learning Algorithm Open
High-throughput mass-spectrometry-based quantitative proteomic analysis was performed using formalin-fixed, paraffin-embedded (FFPE) biopsy samples obtained before treatment from 13 patients with locally advanced rectal cancer (LARC), who …
View article: Quantitative proteomics identifies <scp>TUBB6</scp> as a biomarker of muscle‐invasion and poor prognosis in bladder cancer
Quantitative proteomics identifies <span>TUBB6</span> as a biomarker of muscle‐invasion and poor prognosis in bladder cancer Open
Muscle‐invasive urothelial carcinoma (MIUC) of the bladder shows highly aggressive tumor behavior, which has prompted the quest for robust biomarkers predicting invasion. To discover such biomarkers, we first employed high‐throughput prote…
View article: Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth
Proteomic-Based Machine Learning Analysis Reveals PYGB as a Novel Immunohistochemical Biomarker to Distinguish Inverted Urothelial Papilloma From Low-Grade Papillary Urothelial Carcinoma With Inverted Growth Open
Background The molecular biology of inverted urothelial papilloma (IUP) as a precursor disease of urothelial carcinoma is poorly understood. Furthermore, the overlapping histology between IUP and papillary urothelial carcinoma (PUC) with i…
View article: Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent
Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent Open
Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form of niacin (vitamin B3), is currently available as a supplement for maintaining general physiologic functions. NAM is a crucial regul…
View article: Further Reflections on Zhi Qian’s Foshuo Pusa Benye Jing: Some Terminological Questions
Further Reflections on Zhi Qian’s Foshuo Pusa Benye Jing: Some Terminological Questions Open
Zhi Qian (支謙, fl. ca. 220–257 CE), a prolific Yuezhi-Chinese translator of Indian Buddhist scriptures into Chinese, is widely known for his broad range of styles and terminology. For several decades, his translation activities and his lega…
View article: “Buddhism for Chinese Readers”: Zhi Qian’s Literary Refinements in the Foshuo pusa benye jing
“Buddhism for Chinese Readers”: Zhi Qian’s Literary Refinements in the Foshuo pusa benye jing Open
The present article continues the modern scholarship on the transmission of Buddhism from India to China by focusing on one of the most influential figures among the early Chinese Buddhist translators, namely, Zhi Qian (支謙, ca. 193–252 CE)…
View article: Clinical impact of sarcopenia in patients with uterine cervical cancer treated with radiotherapy
Clinical impact of sarcopenia in patients with uterine cervical cancer treated with radiotherapy Open
Objective: Though sarcopenia is known to be associated with worse prognosis in various tumors, studies regarding the significance of sarcopenia in uterine cervical cancer are uncommon. We investigated the clinical impact of sarcopenia in p…
View article: Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer Open
Background Chemotherapy is the standard treatment for breast cancer; however, the response to chemotherapy is disappointingly low. Here, we investigated the alternative therapeutic efficacy of novel combination treatment with necroptosis-i…
View article: Body mass variations relate to fractionated functional brain hierarchies
Body mass variations relate to fractionated functional brain hierarchies Open
A bstract Variations in body mass index (BMI) have been suggested to relate to atypical brain organization, yet connectome-level substrates of BMI and their neurobiological underpinnings remain unclear. Studying 325 healthy young adults, w…
View article: Moesin (MSN) as a Novel Proteome-Based Diagnostic Marker for Early Detection of Invasive Bladder Urothelial Carcinoma in Liquid-Based Cytology
Moesin (MSN) as a Novel Proteome-Based Diagnostic Marker for Early Detection of Invasive Bladder Urothelial Carcinoma in Liquid-Based Cytology Open
Bladder urothelial carcinoma (BUC) is the most lethal malignancy of the urinary tract. Treatment for the disease highly depends on the invasiveness of cancer cells. Therefore, a predictive biomarker needs to be identified for invasive BUC.…
View article: Additional file 2 of Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
Additional file 2 of Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer Open
Additional file 2. Supplementary table.