Hyein Jang
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View article: TMET-46. Investigating metabolic dependencies during the evolution of glioblastoma
TMET-46. Investigating metabolic dependencies during the evolution of glioblastoma Open
Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults, with a five-year survival rate of less than 7%. GBMs are difficult to treat and often recur within a year of diagnosis. Despite many attempts, treatment o…
View article: Whole genome characterization of thermophilic Campylobacter species isolated from dairy manure in small specialty crop farms of Northeast Ohio
Whole genome characterization of thermophilic Campylobacter species isolated from dairy manure in small specialty crop farms of Northeast Ohio Open
Introduction With more public interest in consuming locally grown produce, small specialty crop farms (SSCF) are a viable and growing segment of the food production chain in the United States. Methods The goal of this study was to investig…
View article: Damped Oscillating Phosphoryl Transfer Reaction in the Cyanobacterial Circadian Clock
Damped Oscillating Phosphoryl Transfer Reaction in the Cyanobacterial Circadian Clock Open
Most organisms have circadian clocks to ensure the metabolic cycle to resonate with the rhythmic environmental changes without "damping," or losing robustness. Cyanobacteria is the oldest and simplest form of life that is known to harbor t…
View article: Development and Single Laboratory Evaluation of a Refined and specific Real-time PCR Detection Method, Using Mitochondrial Primers (Mit1C), for the Detection of Cyclospora cayetanensis in Produce
Development and Single Laboratory Evaluation of a Refined and specific Real-time PCR Detection Method, Using Mitochondrial Primers (Mit1C), for the Detection of Cyclospora cayetanensis in Produce Open
Regulatory methods for detection of the foodborne protozoan parasite Cyclospora cayetanensis must be specific and sensitive. To that end, we designed and evaluated (in a single laboratory validation) a novel and improved primer/probe combi…
View article: Characterization of Cronobacter sakazakii Strains Originating from Plant-Origin Foods Using Comparative Genomic Analyses and Zebrafish Infectivity Studies
Characterization of Cronobacter sakazakii Strains Originating from Plant-Origin Foods Using Comparative Genomic Analyses and Zebrafish Infectivity Studies Open
Cronobacter sakazakii continues to be isolated from ready-to-eat fresh and frozen produce, flours, dairy powders, cereals, nuts, and spices, in addition to the conventional sources of powdered infant formulae (PIF) and PIF production envir…
View article: Phylogenomic Analysis of Salmonella enterica subsp. enterica Serovar Bovismorbificans from Clinical and Food Samples Using Whole Genome Wide Core Genes and kmer Binning Methods to Identify Two Distinct Polyphyletic Genome Pathotypes
Phylogenomic Analysis of Salmonella enterica subsp. enterica Serovar Bovismorbificans from Clinical and Food Samples Using Whole Genome Wide Core Genes and kmer Binning Methods to Identify Two Distinct Polyphyletic Genome Pathotypes Open
Salmonella enterica subsp. enterica serovar Bovismorbificans has caused multiple outbreaks involving the consumption of produce, hummus, and processed meat products worldwide. To elucidate the intra-serovar genomic structure of S. Bovismor…
View article: Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities
Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities Open
Background Cronobacter sakazakii is a foodborne pathogen that causes septicemia, meningitis, and necrotizing enterocolitis in neonates and infants. The current research details the full genome sequences of two extremely persistent C. sakaz…
View article: Additional file 1 of Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities
Additional file 1 of Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities Open
Additional file 1: Table S1. PGAP annotation of genes carried on pH322_1, pH322_2, pGK1025B_1, pGK1025B_2, and pGK1025B_3 that are harbored by C. sakazakii H322 and GK1025B.a.
View article: Additional file 2 of Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities
Additional file 2 of Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities Open
Additional file 2: Table S2. Results of PHASTER analysis for various Cronobacter plasmids including pH322_1, pH322_2, pGK1025B_1, pGK1025B_2, and pGK1025B_3.a.
View article: The antimicrobial interventions of cilantro (<i>Coriandrum sativum</i>) in mitigating cross-contamination of foodborne pathogens during the retail soaking process
The antimicrobial interventions of cilantro (<i>Coriandrum sativum</i>) in mitigating cross-contamination of foodborne pathogens during the retail soaking process Open
The efficacy of commercially available antimicrobials for fresh produce—electrolyzed water (EW; around 60 mg/L of free chlorine), a combination of lactic acid and phosphoric acid-based (LPA) and citric acid-based (CA)—was compared with tap…
View article: Additional file 3 of Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities
Additional file 3 of Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities Open
Additional file 3: Table S3. BLAST analysis of 683 Cronobacter genomes housed in a local database for the presnece of phage-plasmid pH322_1.
View article: Genome Mining Revealed Polyhydroxybutyrate Biosynthesis by Ramlibacter Agri Sp. Nov., Isolated from Agriculture Soil in Korea
Genome Mining Revealed Polyhydroxybutyrate Biosynthesis by Ramlibacter Agri Sp. Nov., Isolated from Agriculture Soil in Korea Open
A white-colony-forming, aerobic, motile and Gram-stain-negative bacterium, designated G-1-2-2 T was isolated from soil of agriculture field near Kyonggi University, Republic of Korea. Strain G-1-2-2 T synthesize the polyhydroxybutyrate and…
View article: The Circadian Clock—A Molecular Tool for Survival in Cyanobacteria
The Circadian Clock—A Molecular Tool for Survival in Cyanobacteria Open
Cyanobacteria are photosynthetic organisms that are known to be responsible for oxygenating Earth’s early atmosphere. Having evolved to ensure optimal survival in the periodic light/dark cycle on this planet, their genetic codes are packed…
View article: Analysis of the Molecular Diversity Among Cronobacter Species Isolated From Filth Flies Using Targeted PCR, Pan Genomic DNA Microarray, and Whole Genome Sequencing Analyses
Analysis of the Molecular Diversity Among Cronobacter Species Isolated From Filth Flies Using Targeted PCR, Pan Genomic DNA Microarray, and Whole Genome Sequencing Analyses Open
Cronobacter species are opportunistic pathogens capable of causing life-threatening infections in humans, with serious complications arising in neonates, infants, immuno-compromised individuals, and elderly adults. The genus is comp…
View article: The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease
The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease Open
Leucine‐rich repeat‐containing proteins (LRR proteins) are involved in supporting a large number of cellular functions. In this review, we summarize recent advancements in understanding functions of the LRR proteins as signaling scaffolds.…
View article: The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence
The Secretion of Toxins and Other Exoproteins of Cronobacter: Role in Virulence, Adaption, and Persistence Open
Cronobacter species are considered an opportunistic group of foodborne pathogenic bacteria capable of causing both intestinal and systemic human disease. This review describes common virulence themes shared among the seven Cronobacter spec…
View article: Single-domain antibodies for functional targeting of the signaling scaffold Shoc2
Single-domain antibodies for functional targeting of the signaling scaffold Shoc2 Open
View article: Prevalence, Distribution, and Phylogeny of Type Two Toxin-Antitoxin Genes Possessed by Cronobacter Species where C. sakazakii Homologs Follow Sequence Type Lineages
Prevalence, Distribution, and Phylogeny of Type Two Toxin-Antitoxin Genes Possessed by Cronobacter Species where C. sakazakii Homologs Follow Sequence Type Lineages Open
Cronobacter species are a group of foodborne pathogenic bacteria that cause both intestinal and systemic human disease in individuals of all age groups. Little is known about the mechanisms that Cronobacter employ to survive and persist in…
View article: VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology
VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology Open
Valosin-containing protein (VCP), also named p97, is an essential hexameric AAA+ ATPase with diverse functions in the ubiquitin system. Here we demonstrate that VCP is critical in controlling signals transmitted via the essential Shoc2-ERK…
View article: Genome-wide survey of efflux pump-coding genes associated with Cronobacter survival, osmotic adaptation, and persistence
Genome-wide survey of efflux pump-coding genes associated with Cronobacter survival, osmotic adaptation, and persistence Open
View article: Draft genomes of Cronobacter sakazakii strains isolated from dried spices bring unique insights into the diversity of plant-associated strains
Draft genomes of Cronobacter sakazakii strains isolated from dried spices bring unique insights into the diversity of plant-associated strains Open
View article: Hematopoietic and neural crest defects in zebrafish<i>shoc2</i>mutants: a novel vertebrate model for Noonan-like syndrome
Hematopoietic and neural crest defects in zebrafish<i>shoc2</i>mutants: a novel vertebrate model for Noonan-like syndrome Open
The extracellular signal-related kinase 1 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essential functions in development. The scaffold protein Shoc2 amplifies the activity of the ERK1/2 pathway and is an es…
View article: Whole-Genome Sequences of Six Listeria monocytogenes Strains Isolated from Food
Whole-Genome Sequences of Six Listeria monocytogenes Strains Isolated from Food Open
Here, we report the whole-genome sequences of six Listeria monocytogenes strains isolated from meat and milk products in Switzerland. All of these strains carry premature stop codons or amino acid deletions in inlA .
View article: Synergistic anti-biofilm effect of natural extracts for Candida albicans inhibition
Synergistic anti-biofilm effect of natural extracts for Candida albicans inhibition Open
View article: First report of an mcr-1-harboring Salmonella enterica subsp. enterica serotype 4,5,12:i:- strain isolated from blood of a patient in Switzerland
First report of an mcr-1-harboring Salmonella enterica subsp. enterica serotype 4,5,12:i:- strain isolated from blood of a patient in Switzerland Open
View article: Whole-Genome Shotgun Sequencing of Three Listeria monocytogenes Strains Isolated from a Ready-to-Eat Salad-Producing Facility in Switzerland
Whole-Genome Shotgun Sequencing of Three Listeria monocytogenes Strains Isolated from a Ready-to-Eat Salad-Producing Facility in Switzerland Open
Ready-to-eat (RTE) raw foods harbor the risk of transmitting Listeria monocytogenes from the environment to the consumer. We isolated three strains from a facility producing RTE salad.
View article: Whole-Genome Sequences of Cronobacter sakazakii Isolates Obtained from Foods of Plant Origin and Dried-Food Manufacturing Environments
Whole-Genome Sequences of Cronobacter sakazakii Isolates Obtained from Foods of Plant Origin and Dried-Food Manufacturing Environments Open
Here, we present draft genome sequences of 29 Cronobacter sakazakii isolates obtained from foods of plant origin and dried-food manufacturing facilities. Assemblies and annotations resulted in genome sizes ranging from 4.3 to 4.5 Mb and 3,…
View article: Genomic characterization of malonate positive Cronobacter sakazakii serotype O:2, sequence type 64 strains, isolated from clinical, food, and environment samples
Genomic characterization of malonate positive Cronobacter sakazakii serotype O:2, sequence type 64 strains, isolated from clinical, food, and environment samples Open
View article: Additional file 4: of Draft genomes of Cronobacter sakazakii strains isolated from dried spices bring unique insights into the diversity of plant-associated strains
Additional file 4: of Draft genomes of Cronobacter sakazakii strains isolated from dried spices bring unique insights into the diversity of plant-associated strains Open
Table S4. Summary table of pESA3-like RAST gene IDs, contig, % identity, and annotations associated with spice-origin C. sakazakii genomes. (XLSX 166â kb)
View article: Functional Characterization of Scaffold Protein Shoc2
Functional Characterization of Scaffold Protein Shoc2 Open
Signaling scaffolds are critical for the correct spatial organization of enzymes within the ERK1/2 signaling pathway and proper transmission of intracellular information. However, mechanisms that control molecular dynamics within scaffoldi…