Hyeonjeong Kang
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View article: Molecular characterisation of foot-and-mouth disease viruses collected from Bangladesh during 2021–23: evidence for trans-pool spread of exotic viral lineages
Molecular characterisation of foot-and-mouth disease viruses collected from Bangladesh during 2021–23: evidence for trans-pool spread of exotic viral lineages Open
Foot-and-mouth disease (FMD) remains endemic in Bangladesh with the persistent circulation of FMD virus (FMDV) serotypes O, A, and Asia 1, underscoring the need for robust epidemiological data to inform and optimize national FMD control st…
View article: Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD
Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD Open
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) …
View article: Multiple incursions of foot-and-mouth disease virus serotype O into the Republic of Korea between 2010 and 2019
Multiple incursions of foot-and-mouth disease virus serotype O into the Republic of Korea between 2010 and 2019 Open
This study characterised type O foot-and-mouth disease (FMD) viruses recovered from outbreaks that were reported between 2010 and 2019 in the Republic of Korea. We used 96 newly generated whole-genome sequences (WGS) along with 131 already…
View article: Re-emergence of foot-and-mouth disease in the Republic of Korea caused by the O/ME-SA/Ind-2001e lineage
Re-emergence of foot-and-mouth disease in the Republic of Korea caused by the O/ME-SA/Ind-2001e lineage Open
The O/ME-SA/Ind-2001e foot-and-mouth disease virus (FMDV) lineage is a pandemic strain that has recently become dominant within East and Southeast Asia. During May 2023, this viral lineage spread to the Republic of Korea, where 11 outbreak…
View article: Data from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Data from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer Open
Purpose:To expand clinical-grade healthy donor-derived double-negative T cells (DNT) to a therapeutically relevant number and characterize their potential to be used as an “off-the-shelf” adoptive cellular therapy (ACT) against cancers.Exp…
View article: Data from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Data from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients.Experimental Design: Clinical-grade…
View article: Supplementary Materials and Methods from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Supplementary Materials and Methods from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer Open
Supplementary Materials and Methods
View article: Supplementary Figures 1-11 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Supplementary Figures 1-11 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Figure S1. Characterization of ex vivo expanded healthy donor (HD) DNTs; Figure S2. Allogeneic DNTs induce dose- and time- dependent cytotoxicity against leukemic cells; Figure S3. Correlation between the susceptibility of AML patient blas…
View article: Supplementary materials and methods from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Supplementary materials and methods from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Additional information on materials and methods used in this study
View article: Data from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Data from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer Open
Purpose:To expand clinical-grade healthy donor-derived double-negative T cells (DNT) to a therapeutically relevant number and characterize their potential to be used as an “off-the-shelf” adoptive cellular therapy (ACT) against cancers.Exp…
View article: Supplementary materials and methods from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Supplementary materials and methods from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Additional information on materials and methods used in this study
View article: Data from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Data from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients.Experimental Design: Clinical-grade…
View article: Supplementary Table 1 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Supplementary Table 1 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Table S1. Clinical information of the 46 AML patients who provided AML cells for in vitro or in vivo assays.
View article: Supplementary Figures from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Supplementary Figures from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer Open
Supplementary Figures
View article: Supplementary Figures 1-11 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Supplementary Figures 1-11 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Figure S1. Characterization of ex vivo expanded healthy donor (HD) DNTs; Figure S2. Allogeneic DNTs induce dose- and time- dependent cytotoxicity against leukemic cells; Figure S3. Correlation between the susceptibility of AML patient blas…
View article: Supplementary Materials and Methods from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Supplementary Materials and Methods from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer Open
Supplementary Materials and Methods
View article: Supplementary Table 1 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Supplementary Table 1 from Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms Open
Table S1. Clinical information of the 46 AML patients who provided AML cells for in vitro or in vivo assays.
View article: Supplementary Figures from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Supplementary Figures from Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer Open
Supplementary Figures
View article: Big data-based risk assessment of poultry farms during the 2020/2021 highly pathogenic avian influenza epidemic in Korea
Big data-based risk assessment of poultry farms during the 2020/2021 highly pathogenic avian influenza epidemic in Korea Open
Outbreaks of H5-type highly pathogenic avian influenza (HPAI) in poultry have been reported in various parts of the world. To respond to these continuous threats, numerous surveillance programs have been applied to poultry raising faciliti…
View article: Enhanced detection and serotyping of foot‐and‐mouth disease virus serotype O, A, and Asia1 using a novel multiplex real‐time RT‐PCR
Enhanced detection and serotyping of foot‐and‐mouth disease virus serotype O, A, and Asia1 using a novel multiplex real‐time RT‐PCR Open
Rapid and accurate detection and serotyping of foot-and-mouth disease (FMD) virus (FMDV) is essential for implementing control policies against emergent FMD outbreaks. Current serotyping assays, such as VP1 reverse transcription-polymerase…
View article: Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib
Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib Open
The double negative T cell (DNT) is a unique subset of T cells with potent anti-leukemic potential. Previously, DNT therapy has been shown to effectively target AML cells in patient-derived xenograft (PDX) models. Further, a recently compl…
View article: State-of-Art of Cellular Therapy for Acute Leukemia
State-of-Art of Cellular Therapy for Acute Leukemia Open
With recent clinical breakthroughs, immunotherapy has become the fourth pillar of cancer treatment. Particularly, immune cell-based therapies have been envisioned as a promising treatment option with curative potential for leukemia patient…
View article: Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production
Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production Open
Venetoclax, a Bcl-2 inhibitor, in combination with the hypomethylating agent azacytidine, achieves complete remission with or without count recovery in ∼70% of treatment-naive elderly patients unfit for conventional intensive chemotherapy.…
View article: CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy
CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy Open
Acute myeloid leukemia (AML) remains a devastating disease in need of new therapies to improve patient survival. Targeted adoptive T-cell therapies have achieved impressive clinical outcomes in some B-cell leukemias and lymphomas but not i…
View article: Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea Open
View article: Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea Open
Background: Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and a primary cause of PCV-associated diseases (PCVAD) that result insubstantial economic loss for swine farms. Between 2016 and 2018, PCV2 field viruses wer…
View article: Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea Open
Background: Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and a primary cause of PCV-associated diseases (PCVAD) that result insubstantial economic loss for swine farms. Between 2016 and 2018, PCV2 field viruses wer…
View article: Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea Open
Background : Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and a primary cause of PCV-associated diseases (PCVAD) that result insubstantial economic loss for swine farms. Between 2016 and 2018, PCV2 field viruses we…
View article: Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea Open
Background: Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and a primary cause of PCV-associated diseases (PCVAD) that result in substantial economic loss for swine farms. Between 2016 and 2018, PCV2 field viruses we…
View article: Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea
Genetic diversity and different cross-neutralization capability of porcine circovirus type 2 isolates recently circulating in South Korea Open
Background : Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and a primary cause of PCV-associated diseases (PCVAD) that result in substantial economic loss for swine farms. Between 2016 and 2018, PCV2 field viruses w…