Sophie Lee
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View article: From Guided Motion to Complex Tasks: Self-Propelled Vesicles as Functional Systems
From Guided Motion to Complex Tasks: Self-Propelled Vesicles as Functional Systems Open
This thesis explores the emergent behaviors and controllable dynamics of self-propelled (SP) colloidal particle swarms confined within deformable vesicles, utilizing molecular dynamics simulations. By investigating these active superstruct…
View article: Daratumumab, cyclophosphamide, bortezomib, and dexamethasone for transplant-ineligible myeloma: AMaRC 03-16
Daratumumab, cyclophosphamide, bortezomib, and dexamethasone for transplant-ineligible myeloma: AMaRC 03-16 Open
In newly diagnosed transplant-ineligible patients with myeloma, daratumumab has improved outcomes when added to the standard-of-care regimens. In a randomized trial, we tested whether similar improvements would be observed when daratumumab…
View article: An intronic RNA element modulates Factor VIII exon-16 splicing
An intronic RNA element modulates Factor VIII exon-16 splicing Open
Pathogenic variants in the human Factor VIII (F8) gene cause Hemophilia A (HA). Here, we investigated the impact of 97 HA-causing single-nucleotide variants on the splicing of 11 exons from F8. For the majority of F8 exons, splicing was in…
View article: Positive Planning With The Happy Student Company
Positive Planning With The Happy Student Company Open
Embarking on the journey of becoming a student midwife is a profound endeavour, one that demands not only knowledge and technical skills but also a significant dose of courage. But as student midwives, can we plan to be courageous? Yes, I …
View article: Rescue of blood coagulation Factor VIII exon-16 mis-splicing by antisense oligonucleotides
Rescue of blood coagulation Factor VIII exon-16 mis-splicing by antisense oligonucleotides Open
The human Factor VIII ( F8 ) protein is essential for the blood coagulation cascade and specific F8 mutations cause the rare bleeding disorder Hemophilia A (HA). Here, we investigated the impact of HA-causing single-nucleotide mutations on…
View article: Positive Planning With The Happy Student Company
Positive Planning With The Happy Student Company Open
How do you look after yourself when you are holding space for others? The Cycle of Caring1 gives us a four-step process in protecting our own mental health when caring for others, particularly when trauma or time-extended care have been in…
View article: A Bayesian modelling framework to quantify multiple sources of spatial variation for disease mapping
A Bayesian modelling framework to quantify multiple sources of spatial variation for disease mapping Open
Spatial connectivity is an important consideration when modelling infectious disease data across a geographical region. Connectivity can arise for many reasons, including shared characteristics between regions and human or vector movement.…
View article: A Bayesian modelling framework to quantify multiple sources of spatial variation for disease mapping
A Bayesian modelling framework to quantify multiple sources of spatial variation for disease mapping Open
Spatial connectivity is an important consideration when modelling infectious disease data across a geographical region. Connectivity can arise for many reasons, including shared characteristics between regions, and human or vector movement…
View article: Pediatric paranasal sinuses—Development, growth, pathology, & functional endoscopic sinus surgery
Pediatric paranasal sinuses—Development, growth, pathology, & functional endoscopic sinus surgery Open
The paranasal sinuses (maxillary, frontal, ethmoid, and sphenoid sinuses) are complex anatomical structures. The development and growth of these have been investigated utilizing a number of different methods ranging from cadaveric analysis…
View article: Positive Planning with The Happy Student Company
Positive Planning with The Happy Student Company Open
When caring for a diverse range of people and their families, sometimes we can make mistakes with the language we use that could potentially cause offence. If you can be a student with a growth mindset, you can find ways to turn these mist…
View article: Ageing causes an aortic contractile dysfunction phenotype by targeting the expression of members of the extracellular signal‐regulated kinase pathway
Ageing causes an aortic contractile dysfunction phenotype by targeting the expression of members of the extracellular signal‐regulated kinase pathway Open
The extracellular signal‐regulated kinase (ERK) pathway is a well‐known regulator of vascular smooth muscle cell proliferation, but it also serves as a regulator of caldesmon, which negatively regulates vascular contractility. This study e…
View article: Impaired neutralisation of SARS-CoV-2 delta variant in vaccinated patients with B cell chronic lymphocytic leukaemia
Impaired neutralisation of SARS-CoV-2 delta variant in vaccinated patients with B cell chronic lymphocytic leukaemia Open
View article: Positive Planning with The Happy Student Company – Boundaries
Positive Planning with The Happy Student Company – Boundaries Open
January brings about a new sense of starting afresh, and the opportunity to make new choices in how we look after ourselves in the year going forward. You can choose habits and boundaries that will benefit you or disadvantage you.
View article: The impact of climate suitability, urbanisation, and connectivity on the expansion of dengue in 21st century Brazil
The impact of climate suitability, urbanisation, and connectivity on the expansion of dengue in 21st century Brazil Open
Dengue is hyperendemic in Brazil, with outbreaks affecting all regions. Previous studies identified geographical barriers to dengue transmission in Brazil, beyond which certain areas, such as South Brazil and the Amazon rainforest, were re…
View article: SARS-CoV-2 vaccine responses following CD20-depletion treatment in patients with haematological and rheumatological disease: a West Midlands Research Consortium study
SARS-CoV-2 vaccine responses following CD20-depletion treatment in patients with haematological and rheumatological disease: a West Midlands Research Consortium study Open
B-cell-depleting agents are among the most commonly used drugs to treat haemato-oncological and autoimmune diseases. They rapidly induce a state of peripheral B-cell aplasia with the potential to interfere with nascent vaccine responses, p…
View article: Data and R code to accompany 'The impact of climate suitability, urbanisation, and connectivity on the expansion of dengue in 21st century Brazil' (version 1.0.0)
Data and R code to accompany 'The impact of climate suitability, urbanisation, and connectivity on the expansion of dengue in 21st century Brazil' (version 1.0.0) Open
Dengue is hyperendemic in Brazil, with outbreaks affecting all regions. Previous studies identified geographical barriers to dengue transmission in Brazil, beyond which certain areas, such as South Brazil and the Amazon rainforest, were re…
View article: Vaccine Efficacy after Rituximab Exposure: First Interim Analysis of Virtue Project on Behalf of West Midlands Research Consortium, UK
Vaccine Efficacy after Rituximab Exposure: First Interim Analysis of Virtue Project on Behalf of West Midlands Research Consortium, UK Open
Background: Anti-CD20 B cell depleting agents are amongst the most commonly used immunotherapeutics employed in the treatment of haematological malignancy and autoimmune diseases. By inducing peripheral B cell aplasia, anti-CD20 depleting …
View article: A Randomized Study of Bortezomib, Cyclophosphamide and Dexamethasone Induction (VCD) Versus VCD and Daratumumab Induction Followed By Daratumumab Maintenance (VCDD) for the Initial Treatment of Transplant-Ineligible Patients with Multiple Myeloma (AMaRC 03-16)
A Randomized Study of Bortezomib, Cyclophosphamide and Dexamethasone Induction (VCD) Versus VCD and Daratumumab Induction Followed By Daratumumab Maintenance (VCDD) for the Initial Treatment of Transplant-Ineligible Patients with Multiple Myeloma (AMaRC 03-16) Open
Introduction Daratumumab, when added to standard of care regimens in relapsed and untreated myeloma, has consistently demonstrated significant improvements in response rates, induction of MRD negative responses and prolonged progression-fr…
View article: Positive Planning with The Happy STUDENT Company
Positive Planning with The Happy STUDENT Company Open
A major component of building your resilience and self-development when moving forward is reflecting. Reflection is one of your greatest tools as a clinical practitioner, continuing throughout your career. It requires practice and evaluati…
View article: The impact of climate suitability, urbanisation, and connectivity on the expansion of dengue in 21st century Brazil
The impact of climate suitability, urbanisation, and connectivity on the expansion of dengue in 21st century Brazil Open
Dengue is hyperendemic in Brazil, with outbreaks affecting all regions. Previous studies identified geographical barriers to dengue transmission in Brazil, beyond which certain areas, such as South Brazil and the Amazon rainforest, were re…
View article: Positive Planning with The Happy STUDENT Company
Positive Planning with The Happy STUDENT Company Open
Resilience can mean so many things to different people. I love exploring resilience in the context of personal development. Personal resilience is an area that cannot be measured by others, but only by your own sense of growth and wellbein…
View article: Spatial connectivity in mosquito-borne disease models: a systematic review of methods and assumptions
Spatial connectivity in mosquito-borne disease models: a systematic review of methods and assumptions Open
Spatial connectivity plays an important role in mosquito-borne disease transmission. Connectivity can arise for many reasons, including shared environments, vector ecology and human movement. This systematic review synthesizes the spatial …
View article: Data and R code to accompany 'Spatial connectivity in mosquito-borne disease models: a systematic review of methods and assumptions' (version v1.0.0).
Data and R code to accompany 'Spatial connectivity in mosquito-borne disease models: a systematic review of methods and assumptions' (version v1.0.0). Open
This is the first release.
View article: The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson’s disease
The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson’s disease Open
View article: Combined effects of hydrometeorological hazards and urbanisation on dengue risk in Brazil: a spatiotemporal modelling study
Combined effects of hydrometeorological hazards and urbanisation on dengue risk in Brazil: a spatiotemporal modelling study Open
View article: Effect of climate change, connectivity, and socioeconomic factors on the expansion of the dengue virus transmission zone in 21st century Brazil: an ecological modelling study
Effect of climate change, connectivity, and socioeconomic factors on the expansion of the dengue virus transmission zone in 21st century Brazil: an ecological modelling study Open
View article: Impaired Neutralisation of SARS-CoV-2 Delta Variant in Vaccinated Patients With B Cell Chronic Lymphocytic Leukaemia
Impaired Neutralisation of SARS-CoV-2 Delta Variant in Vaccinated Patients With B Cell Chronic Lymphocytic Leukaemia Open
View article: Build Your Network – Build Your Resilience
Build Your Network – Build Your Resilience Open
I believe that the UK is beginning the new year with much more in common with the rest of the world than it did at the start of 2020. Having spent much of last year in isolation of one form or another, students in the UK endured this new n…
View article: Emerging arboviruses in the urbanized Amazon rainforest
Emerging arboviruses in the urbanized Amazon rainforest Open
Degradation of rainforest, extreme weather events, and climate change affect the spread of mosquito borne diseases like dengue, chikungunya, and Zika, write Rachel Lowe and colleagues. Urgent action is needed
View article: Positive Planning with The Happy Planner Company
Positive Planning with The Happy Planner Company Open
How do you rise from adversity? Do you have a strategy in place? It’s not easy to plan for the unknown, nor is it a simple process to recover from unexpected setbacks! Looking after your mental and physical wellbeing is fundamental to pers…