Hyewon Phee
YOU?
Author Swipe
View article: Diagnosing Type 2 Inflammation in COPD: Comparison of Blood and Sputum Eosinophil Assessment in the University of California, Los Angeles COPD Phenotyping Study
Diagnosing Type 2 Inflammation in COPD: Comparison of Blood and Sputum Eosinophil Assessment in the University of California, Los Angeles COPD Phenotyping Study Open
In stable COPD patients, BEC and SpE% did not correlate well, and blood- and sputum-based diagnostic criteria identified different individuals. Defining eosinophilic COPD requires a better understanding of the bio-compartment sampled, test…
View article: Corrigendum: Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies
Corrigendum: Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies Open
[This corrects the article DOI: 10.3389/fimmu.2023.1272055.].
View article: 1078 Agonistic CD40 IgM antibodies enhance immune responses beyond that of IgGs
1078 Agonistic CD40 IgM antibodies enhance immune responses beyond that of IgGs Open
Background Tumor necrosis factor receptor (TNFR) superfamily member CD40 plays key roles in mediating innate and adaptive immune responses against tumors and requires trimerization to induce agonistic signaling. Anti-CD40 therapeutic IgG a…
View article: 1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo
1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo Open
Background 4–1BB is an inducible costimulatory receptor expressed on activated T and natural killer cells. 4–1BB activation triggers an NFkB signaling cascade that results in effector cell proliferation and cytokine production. Since recep…
View article: CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis
CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis Open
Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in part via the production of the proinflammatory cytokine interleukin-12. Thus, depletion of DC1 has the potential to dampen…
View article: Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies
Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies Open
Conventional type 1 dendritic cells (cDC1s) are superior in antigen cross-presentation and priming CD8 + T cell anti-tumor immunity and thus, are a target of high interest for cancer immunotherapy. Type I interferon (IFN) is a potent induc…
View article: Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy
Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy Open
Autoimmune diseases affect roughly 5-10% of the total population, with women affected more than men. The standard treatment for autoimmune or autoinflammatory diseases had long been immunosuppressive agents until the advent of immunomodula…
View article: <i>Listeria monocytogenes</i>personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens
<i>Listeria monocytogenes</i>personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens Open
Background Recent advances in the field of cancer immunotherapy have identified CD8 + T cell responses against tumor-specific mutations as a key driver of tumor regression and overall survival. ADXS-NEO is a personalized Listeria monocytog…
View article: Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein
Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein Open
The therapeutic expansion of Foxp3 + regulatory T cells (Tregs) shows promise for treating autoimmune and inflammatory disorders. Yet, how this treatment affects the heterogeneity and function of Tregs is not clear. Using single-cell RNA-s…
View article: Dynamic changes in the regulatory T cell heterogeneity and function by murine IL-2 mutein
Dynamic changes in the regulatory T cell heterogeneity and function by murine IL-2 mutein Open
The therapeutic expansion of Foxp3 + regulatory T cells (Tregs) shows promise for treating autoimmune and inflammatory disorders. Yet, how this treatment affects the heterogeneity and function of Tregs is not clear. Using single-cell RNA-s…
View article: P21‐activated kinase 2 is essential in maintenance of peripheral Foxp3<sup>+</sup> regulatory T cells
P21‐activated kinase 2 is essential in maintenance of peripheral Foxp3<sup>+</sup> regulatory T cells Open
Summary The p21‐activated kinase 2 (Pak2), an effector molecule of the Rho family GTPases Rac and Cdc42, regulates diverse functions of T cells. Previously, we showed that Pak2 is required for development and maturation of T cells in the t…
View article: Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype
Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype Open
Foxp3, a key transcription factor that drives lineage differentiation of regulatory T cells (Tregs), was thought to imprint a unique and irreversible genetic signature within Tregs. Recent evidence, however, suggests that loss or attenuati…
View article: Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2
Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2 Open
NKT cells constitute a small population of T cells developed in the thymus that produce large amounts of cytokines and chemokines in response to lipid Ags. Signaling through the Vα14-Jα18 TCR instructs commitment to the NKT cell lineage, b…
View article: Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance Open
Although significant effort has been devoted to understanding the thymic development of Foxp3+ regulatory T cells (Tregs), the precise signaling pathways that govern their lineage commitment still remain enigmatic. Our findings show a nove…