Hyo‐Jung Lee
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View article: Comprehensive profiling of plasma and exosomal microRNAs in medication-related osteonecrosis of the jaw
Comprehensive profiling of plasma and exosomal microRNAs in medication-related osteonecrosis of the jaw Open
View article: “I’m more confident now than I ever used to be”: a preliminary qualitative study of British older adults’ perception and experience of aging positively
“I’m more confident now than I ever used to be”: a preliminary qualitative study of British older adults’ perception and experience of aging positively Open
Background and Objectives With the changing demographic of older adults population observed around the world, it is important that aging is not simply conceptualized as decline in functioning and physical health, but encompasses positive e…
View article: Distinct microbiome composition and reduced interactions in patients with pancreatic cancer
Distinct microbiome composition and reduced interactions in patients with pancreatic cancer Open
Introduction The results of microbiome composition in patients with malignancy have been inconsistent across studies and are affected by various factors. This study aimed to identify microbiome composition of saliva, feces, and blood in pa…
View article: Consequence of Bisphosphonate Use on Dental Implant Removal in Osteoporotic Patient: A Nationwide Cohort Study
Consequence of Bisphosphonate Use on Dental Implant Removal in Osteoporotic Patient: A Nationwide Cohort Study Open
Introduction This nationwide population‐based cohort study aimed to investigate the relationship between bisphosphonate (BP) use and dental implant removal in patients with osteoporosis. Methods A total of 389 226 individuals aged ≥ 65 yea…
View article: Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients
Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients Open
Medication-related osteonecrosis of the jaw is a rare but serious condition in which the jawbone fails to heal and becomes necrotic, typically after dental surgery in patients treated with bisphosphonates. However, clear evidence guiding h…
View article: Association between root canals and gingival sulci microbiota in secondary and persistent endodontic infections
Association between root canals and gingival sulci microbiota in secondary and persistent endodontic infections Open
View article: Oral microbiome changes in subjects with obesity following bariatric surgery compared to lean counterparts
Oral microbiome changes in subjects with obesity following bariatric surgery compared to lean counterparts Open
Introduction This study aimed to compare oral microbiome profiles between obese and lean individuals without clinical periodontitis, and to assess changes in the oral microbiome of obese subjects following bariatric surgery. Methods Indivi…
View article: CRY1 fuels resistance to T cell-based immunotherapy in NANOGhigh cancers
CRY1 fuels resistance to T cell-based immunotherapy in NANOGhigh cancers Open
Cancer immunotherapies, including immune checkpoint blockade (ICB), have marked a significant breakthrough in cancer treatment but their clinical efficacy is limited in immune-resistant tumors. Previously, we found that immunotherapy-media…
View article: Metagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case–control study
Metagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case–control study Open
These findings suggested that the oral microbiome composition may serve as an indicator of tumorigenesis in upper GI and pancreaticobiliary cancers. The development of oral metagenomic classifiers for EC and GC demonstrates the potential v…
View article: Consensus statement on peri-implant disease from the Korean Academy of Periodontology
Consensus statement on peri-implant disease from the Korean Academy of Periodontology Open
This consensus report presents the first official position statement of the Korean Academy of Periodontology on peri-implant diseases, issued in response to South Korea's rapidly aging population and the associated rise in peri-implant dis…
View article: Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease
Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease Open
To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We determined the HPV type and analyzed the expression of 51 genes. HPV31 was significantly more prevalent in precancer…
View article: CARE NEEDS AND LIFE SATISFACTION IN FRAIL OLDER ADULTS: THE MODERATING EFFECT OF AGE-FRIENDLY ENVIRONMENTS
CARE NEEDS AND LIFE SATISFACTION IN FRAIL OLDER ADULTS: THE MODERATING EFFECT OF AGE-FRIENDLY ENVIRONMENTS Open
Frail older adults often face challenges in performing Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL), leading to diminished quality of life. Age-friendly environments, designed to facilitate aging in p…
View article: Study on the Relation of Climate Change-Ozone in Seoul and Busan : Comparative Study on Busan vs Seoul Metropolitan Area (V)
Study on the Relation of Climate Change-Ozone in Seoul and Busan : Comparative Study on Busan vs Seoul Metropolitan Area (V) Open
View article: Analysis of the progression of cervical cancer in Guatemala- from pre-malignancy to invasive disease
Analysis of the progression of cervical cancer in Guatemala- from pre-malignancy to invasive disease Open
To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy We determined HPV type and analyzed the expression of 51 genes. HPV31 was significantly more prevalent in precancer than…
View article: Distinct microbiome composition and reduced interactions in patients with pancreatic cancer
Distinct microbiome composition and reduced interactions in patients with pancreatic cancer Open
Background The results of microbiome composition in patients with malignancy have been inconsistent across studies and are affected by various factors. This study aimed to identify microbiome composition of saliva, feces, and blood in pati…
View article: Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin
Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin Open
Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particula…
View article: Anti-Warburg Mechanism of Ginsenoside F2 in Human Cervical Cancer Cells via Activation of miR193a-5p and Inhibition of β-Catenin/c-Myc/Hexokinase 2 Signaling Axis
Anti-Warburg Mechanism of Ginsenoside F2 in Human Cervical Cancer Cells via Activation of miR193a-5p and Inhibition of β-Catenin/c-Myc/Hexokinase 2 Signaling Axis Open
Though Ginsenoside F2 (GF2), a protopanaxadiol saponin from Panax ginseng, is known to have an anticancer effect, its underlying mechanism still remains unclear. In our model, the anti-glycolytic mechanism of GF2 was investigated in human …
View article: Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin
Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin Open
Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particula…
View article: Discovery of a new long COVID mouse model via systemic histopathological comparison of SARS-CoV-2 intranasal and inhalation infection
Discovery of a new long COVID mouse model via systemic histopathological comparison of SARS-CoV-2 intranasal and inhalation infection Open
Intranasal infection is commonly used to establish a SARS-CoV-2 mouse model due to its non-invasive procedures and a minimal effect from the operation itself. However, mice intranasally infected with SARS-CoV-2 have a high mortality rate, …
View article: Saliva assay: a call for methodological standardization
Saliva assay: a call for methodological standardization Open
The oral cavity provides an ideal environment for microorganisms, including bacteria, viruses, and fungi, to flourish. Increasing attention has been focused on the connection between the oral microbiome and both oral and systemic diseases,…
View article: Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review Open
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain injury. Even if there is no direct lung damage, severe brain injury can enhance sympathetic t…
View article: One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea
One-year mortality and morbidities of severe fever with thrombocytopenia syndrome compared with other diseases: A nationwide cohort study in South Korea Open
Background The long-term mortality and morbidity of patients with severe fever with thrombocytopenia syndrome (SFTS) remain unclear. Methods This retrospective cohort study was conducted using the National Health Insurance Service dataset …
View article: Genetic classification of various familial relationships using the stacking ensemble machine learning approaches
Genetic classification of various familial relationships using the stacking ensemble machine learning approaches Open
Familial searching is a useful technique in a forensic investigation.Using genetic information, it is possible to identify individuals, determine familial relationships, and obtain racial/ethnic information.The total number of shared allel…
View article: Comparison of the performance of MiSeq and NovaSeq in oral microbiome study
Comparison of the performance of MiSeq and NovaSeq in oral microbiome study Open
Taken together, while both MiSeq and NovaSeq platforms effectively characterize the oral microbiome, NovaSeq outperformed MiSeq in terms of read counts and detection of unique OTUs, highlighting its potential as a valuable tool for large s…
View article: Astragalus membranaceus Extract Induces Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Heat Shock Protein 27 and Androgen Receptor in Prostate Cancers
Astragalus membranaceus Extract Induces Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Heat Shock Protein 27 and Androgen Receptor in Prostate Cancers Open
Although Astragalus membranaceus is known to have anti-inflammatory, anti-obesity, and anti-oxidant properties, the underlying apoptotic mechanism of Astragalus membranaceus extract has never been elucidated in prostate cancer. In this pap…
View article: Association between toothbrushing and cardiovascular risk factors: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2015–2017
Association between toothbrushing and cardiovascular risk factors: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2015–2017 Open
View article: Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy
Negative Regulation of CPSF6 Suppresses the Warburg Effect and Angiogenesis Leading to Tumor Progression Via c-Myc Signaling Network: Potential Therapeutic Target for Liver Cancer Therapy Open
In this study, we explored the oncogenic mechanism of cleavage and polyadenylation-specific factor 6 (CPSF6) in hepatocellular carcinoma (HCC). CPSF6 was overexpressed in HCC tissues with poor survival rates compared to normal tissues. Hen…
View article: Current understanding of the etiology, diagnosis, treatment, and management of peri-implant diseases: a narrative review for the consensus report of the Korean Academy of Periodontology
Current understanding of the etiology, diagnosis, treatment, and management of peri-implant diseases: a narrative review for the consensus report of the Korean Academy of Periodontology Open
Over the past few decades, dental implants have been successfully utilized to replace teeth lost due to periodontal disease and other conditions. However, similar to natural teeth, dental implants are vulnerable to inflammatory peri-implan…
View article: Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs
Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs Open
View article: A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice
A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice Open