Hyosil Kim
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View article: CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects
CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects Open
CRISPR/Cas9 technology has effectively targeted cancer-specific oncogenic hotspot mutations or insertion–deletions. However, their limited prevalence in tumors restricts their application. We propose a novel approach targeting passenger si…
View article: Identification of Pharmacologically Tractable Protein Complexes in Cancer Using the R-Based Network Clustering and Visualization Program MCODER
Identification of Pharmacologically Tractable Protein Complexes in Cancer Using the R-Based Network Clustering and Visualization Program MCODER Open
Current multiomics assay platforms facilitate systematic identification of functional entities that are mappable in a biological network, and computational methods that are better able to detect densely connected clusters of signals within…
View article: Correction: Meta-Analysis of Large-Scale Toxicogenomic Data Finds Neuronal Regeneration Related Protein and Cathepsin D to Be Novel Biomarkers of Drug-Induced Toxicity
Correction: Meta-Analysis of Large-Scale Toxicogenomic Data Finds Neuronal Regeneration Related Protein and Cathepsin D to Be Novel Biomarkers of Drug-Induced Toxicity Open
[This corrects the article DOI: 10.1371/journal.pone.0136698.].
View article: Meta-analysis method for discovering reliable biomarkers by integrating statistical and biological approaches: An application to liver toxicity
Meta-analysis method for discovering reliable biomarkers by integrating statistical and biological approaches: An application to liver toxicity Open
Biomarkers that are identified from a single study often appear to be biologically irrelevant or false positives. Meta-analysis techniques allow integrating data from multiple studies that are related but independent in order to identify b…