Hye Seung Lee
YOU?
Author Swipe
View article: Textbook outcome of gastric cancer surgery and lymph node evaluation as its parameter to improve long-term survival
Textbook outcome of gastric cancer surgery and lymph node evaluation as its parameter to improve long-term survival Open
The textbook outcome (TO) is a short-term outcome that integrates postoperative outcomes to evaluate the quality of surgery. In gastric cancer surgery, most TO data have been reported from Western countries. We aimed to analyze TO in Korea…
View article: Analysis of T Cell Subsets Using Multiplex Immunohistochemistry and Clinical Outcomes of Immune Checkpoint Inhibitors in Advanced Gastric Cancer Patients
Analysis of T Cell Subsets Using Multiplex Immunohistochemistry and Clinical Outcomes of Immune Checkpoint Inhibitors in Advanced Gastric Cancer Patients Open
T-cell subsets within the tumor microenvironment were associated with the clinical efficacy of ICIs in GC. PD-1- or TIM-3 expressing T-cells were also associated with response to ICIs, while memory T-cells subsets were associated with surv…
View article: Feasibility of Anti-CEA Dye Conjugate for Cancer-Specific Imaging in Gastric Cancer Cell Lines and Mouse Xenograft Models
Feasibility of Anti-CEA Dye Conjugate for Cancer-Specific Imaging in Gastric Cancer Cell Lines and Mouse Xenograft Models Open
Purpose: Near-infrared fluorescence-guided surgery (FGS) using cancer-specific tracers is promising for tailored gastric cancer (GC) surgery. Carcinoembryonic antigen (CEA) is a potential target due to its high expression in various digest…
View article: Clinicopathological Factors Influencing PD-L1 Expression and The Effect of Immune Checkpoint Inhibitors on Survival Outcomes in Patients with Gastric Cancer Depending on Sex in a Tertiary Hospital in South Korea
Clinicopathological Factors Influencing PD-L1 Expression and The Effect of Immune Checkpoint Inhibitors on Survival Outcomes in Patients with Gastric Cancer Depending on Sex in a Tertiary Hospital in South Korea Open
PD-L1 expression and therapeutic efficacy of ICIs differ by sex in GC. EBV infection and antral tumor location were independent factors in males, while MSI-H status was significant in females. These findings highlights the importance of se…
View article: Prediction of hematogenous metastasis risk from molecular classification in gastric cancer
Prediction of hematogenous metastasis risk from molecular classification in gastric cancer Open
Background: Hematogenous metastasis (HM) poses a significant challenge in the treatment and outcome of gastric cancer (GC). This study identified and characterized molecular subtypes of GC associated with HM to develop predictive models an…
View article: Survival Rates of Patients with Gastric Cancer According to Age and Sex: A Large-Scale Study Using Data from 14,739 Patients
Survival Rates of Patients with Gastric Cancer According to Age and Sex: A Large-Scale Study Using Data from 14,739 Patients Open
Age and stage stratification revealed significant differences in survival between the sexes, which can be helpful for public health strategies.
View article: Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital
Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital Open
Next-generation sequencing (NGS) cancer profiling has gained traction in routine clinical practice in South Korea. Here, we evaluated the use of NGS testing and genomically-matched therapies for patients with advanced solid tumors in a rea…
View article: Impact of resection margin status on survival in gastric cancer: A retrospective cohort study
Impact of resection margin status on survival in gastric cancer: A retrospective cohort study Open
R1 resection significantly impairs survival across all stages of gastric cancer, with the extent and depth of microscopic involvement influencing prognosis. When R1 status is discovered postoperatively, subsequent resection should be consi…
View article: Spatial and Temporal Tumor Heterogeneity in Gastric Cancer: Discordance of Predictive Biomarkers
Spatial and Temporal Tumor Heterogeneity in Gastric Cancer: Discordance of Predictive Biomarkers Open
Gastric cancer (GC) is a highly heterogeneous disease that varies in both histological presentation and genetic characteristics. Recent advances in the treatment of metastatic and unresectable GC have made several biomarker tests essential…
View article: Clinicopathologic and molecular characterization of stages II-IV gastric cancer with Claudin 18.2 expression
Clinicopathologic and molecular characterization of stages II-IV gastric cancer with Claudin 18.2 expression Open
Background Claudin 18.2 (CLDN18.2) is a promising target for targeted therapies in gastric cancer (GC). This study investigated the prevalence of CLDN18.2 expression in patients with stages II-IV GC or gastroesophageal junction (GEJ) adeno…
View article: Virtual staining-based tumor microenvironment model predicting prognosis of gastric cancer
Virtual staining-based tumor microenvironment model predicting prognosis of gastric cancer Open
The tumor microenvironment (TME) consists of tumor-associated stroma and tumor infiltrating lymphocytes (TIL). Assessment of tumor-stroma ratio (TSR) and TIL in the histopathological specimens can provide important prognostic information i…
View article: Effector Function Characteristics of Exhausted CD8+ T-Cell in Microsatellite Stable and Unstable Gastric Cancer
Effector Function Characteristics of Exhausted CD8+ T-Cell in Microsatellite Stable and Unstable Gastric Cancer Open
Purpose Gastric cancer exhibits molecular heterogeneity, with the microsatellite instability–high (MSI-H) subtype drawing attention for its distinct features. Despite a higher survival rate, MSI-H gastric cancer lack significant benefits f…
View article: Applicability of Spatial Technology in Cancer Research
Applicability of Spatial Technology in Cancer Research Open
This review explores spatial mapping technologies in cancer research, highlighting their crucial role in understanding the complexities of the tumor microenvironment (TME). The TME, which is an intricate ecosystem of diverse cell types, ha…
View article: Sex-dependent different clinicopathological characterization of Epstein–Barr virus-associated gastric carcinoma: a large-scale study
Sex-dependent different clinicopathological characterization of Epstein–Barr virus-associated gastric carcinoma: a large-scale study Open
Background Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) has been reported to account for approximately 5–16% of all GCs with good prognosis compared to EBV-negative GC. We evaluated the clinicopathological characteristics of…
View article: Clinical practice recommendations for the use of next-generation sequencing in patients with solid cancer: a joint report from KSMO and KSP
Clinical practice recommendations for the use of next-generation sequencing in patients with solid cancer: a joint report from KSMO and KSP Open
In recent years, next-generation sequencing (NGS)–based genetic testing has become crucial in cancer care. While its primary objective is to identify actionable genetic alterations to guide treatment decisions, its scope has broadened to e…
View article: Clinicopathologic Characteristics of Trop Family Proteins (Trop-2 and EpCAM) in Gastric Carcinoma
Clinicopathologic Characteristics of Trop Family Proteins (Trop-2 and EpCAM) in Gastric Carcinoma Open
These results highlight the differential expression of Trop-2 and EpCAM and their prognostic implications in GC. The use of meticulously validated antibodies ensured the reliability of our IHC data, thereby offering a robust foundation for…
View article: Concordance of circulating tumor DNA and matched formalin-fixed paraffin-embedded tumor tissue in gastric cancer as a predictor of recurrence
Concordance of circulating tumor DNA and matched formalin-fixed paraffin-embedded tumor tissue in gastric cancer as a predictor of recurrence Open
Purpose: Combined analysis of the variant composition of circulating tumor DNA (ctDNA) from cell-free plasma and DNA from tumor tissue could provide insight into the implications of the genetic alterations responsible for the intratumoral …
View article: Clinical Practice Recommendations for the Use of Next-Generation Sequencing in Patients with Solid Cancer: A Joint Report from KSMO and KSP
Clinical Practice Recommendations for the Use of Next-Generation Sequencing in Patients with Solid Cancer: A Joint Report from KSMO and KSP Open
In recent years, next-generation sequencing (NGS)–based genetic testing has become crucial in cancer care. While its primary objective is to identify actionable genetic alterations to guide treatment decisions, its scope has broadened to e…
View article: Artificial intelligence-powered spatial analysis of tumor-infiltrating lymphocytes for prediction of prognosis in resected colon cancer
Artificial intelligence-powered spatial analysis of tumor-infiltrating lymphocytes for prediction of prognosis in resected colon cancer Open
Tumor-infiltrating lymphocytes (TIL) have been suggested as an important prognostic marker in colorectal cancer, but assessment usually requires additional tissue processing and interpretational efforts. The aim of this study is to assess …
View article: Different oncological features of colorectal cancer codon-specific <i>KRAS</i> mutations: Not codon 13 but codon 12 have prognostic value
Different oncological features of colorectal cancer codon-specific <i>KRAS</i> mutations: Not codon 13 but codon 12 have prognostic value Open
The robotic liver resection (RLR) has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system, however, controversies still exist. Based on the foundati…
View article: Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis
Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis Open
Purpose Bone metastasis (BM) adversely affects the prognosis of gastric cancer (GC). We investigated molecular features and immune microenvironment that characterize GC with BM compared to GC without BM.Materials and Methods Targeted DNA a…
View article: Combination of acalabrutinib with rituximab and lenalidomide in relapsed/refractory B cell non‐Hodgkin lymphoma
Combination of acalabrutinib with rituximab and lenalidomide in relapsed/refractory B cell non‐Hodgkin lymphoma Open
Introduction: Previous studies have shown that combination of acalabrutinib with rituximab and lenalidomide has a synergistic effect in killing NHL cells. We hypothesized that the R2A regimen would show satisfying efficacy for relapsed/ref…
View article: P-092 EARLY OUTCOMES OF ROBOTIC-ASSISTED TRANSABDOMINAL PREPERITONEAL INGUINAL HERNIA REPAIR: A SINGLE-INSTITUTION EXPERIENCE
P-092 EARLY OUTCOMES OF ROBOTIC-ASSISTED TRANSABDOMINAL PREPERITONEAL INGUINAL HERNIA REPAIR: A SINGLE-INSTITUTION EXPERIENCE Open
Purpose Since the introduction of the Da Vinci robot, robot-assisted hernia repairs have become more common. We aim to report our initial experience of robotic transabdominal preperitoneal (R-TAPP) inguinal hernia repair. Methods A retrosp…
View article: AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20)
AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20) Open
Background Loss of PTEN function leads to increased PI3Kβ signaling. AZD8186, a selective PI3Kβ/δ inhibitor, has shown anti-tumor activity in PTEN-deficient preclinical models. This phase 1b/2 study was conducted to determine the safety an…