Hyuk Soo Eun
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View article: Enzyme-free chemical DNA ligation via amine-crosslinker-mediated DNA assembly for miRNA detection
Enzyme-free chemical DNA ligation via amine-crosslinker-mediated DNA assembly for miRNA detection Open
View article: Cell-Free DNA Versus Circulating Tumor Cells: A Pilot Study of Alpha-Fetoprotein Analysis for Diagnosis and Treatment Monitoring in Hepatocellular Carcinoma
Cell-Free DNA Versus Circulating Tumor Cells: A Pilot Study of Alpha-Fetoprotein Analysis for Diagnosis and Treatment Monitoring in Hepatocellular Carcinoma Open
Serum alpha-fetoprotein (AFP) is widely used for hepatocellular carcinoma (HCC) management, yet its limited sensitivity and specificity restrict diagnostic and prognostic utility. In this study, we explore the clinical potential of AFP qua…
View article: Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response
Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response Open
A major challenge in immunotherapy is the inability to reliably predict patient responses due to the lack of robust biomarkers. Programmed cell death‐ligand 1 (PD‐L1)–expressing exosomes represent a promising biomarker candidate; however, …
View article: Association between cholecystectomy and the risk of new-onset metabolic dysfunction-associated steatotic liver disease: a risk-stratified cohort study
Association between cholecystectomy and the risk of new-onset metabolic dysfunction-associated steatotic liver disease: a risk-stratified cohort study Open
Cholecystectomy has been reported to be associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD), but the extent and modifying factors of this association remain unclear. We analyzed 661,122 ind…
View article: Sugar-sweetened beverage consumption and metabolic dysfunction-associated steatotic liver disease: a beverage type-specific analysis using Korea National Health and Nutrition Examination Survey
Sugar-sweetened beverage consumption and metabolic dysfunction-associated steatotic liver disease: a beverage type-specific analysis using Korea National Health and Nutrition Examination Survey Open
OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease. Evidence indicates a relationship between sugar-sweetened beverage (SSB) consumption and MASLD development; however, the effe…
View article: Temporal Dynamics and Treatment Outcomes of Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: A Multicenter Retrospective Study from South Korea
Temporal Dynamics and Treatment Outcomes of Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: A Multicenter Retrospective Study from South Korea Open
In South Korea, patients with HCV/HIV coinfection were predominantly male and younger and exhibited a higher prevalence of genotype 1a than those with HCV monoinfection. These patients demonstrated a significantly better treatment response…
View article: Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells Open
View article: Vitamin D supplementation ameliorates ductular reaction, liver inflammation and fibrosis in mice by upregulating TXNIP in ductular cells
Vitamin D supplementation ameliorates ductular reaction, liver inflammation and fibrosis in mice by upregulating TXNIP in ductular cells Open
View article: Proportional Correlation Between Systemic Inflammation Response Index and Gastric Cancer Recurrence Time: A Retrospective Study
Proportional Correlation Between Systemic Inflammation Response Index and Gastric Cancer Recurrence Time: A Retrospective Study Open
Background: Disease recurrence is the primary cause of death in patients with gastric cancer who have undergone complete surgical resection. No prognostic factors for recurrence, other than the Tumor, Node, and Metastasis stage, have been …
View article: The Solute Carrier Superfamily as Therapeutic Targets in Pancreatic Ductal Adenocarcinoma
The Solute Carrier Superfamily as Therapeutic Targets in Pancreatic Ductal Adenocarcinoma Open
Background: Pancreatic ductal adenocarcinoma (PDAC), a challenging and malignant cancer, primarily originates from the exocrine cells of the pancreas. The superfamily of solute carrier (SLC) transporters, consisting of more than 450 protei…
View article: Association of Survival with Radiologic-Pathologic Discordance in Patients with Hepatocellular Carcinoma: A Nationwide Cohort Study Based on the Primary Liver Cancer Registry in Korea
Association of Survival with Radiologic-Pathologic Discordance in Patients with Hepatocellular Carcinoma: A Nationwide Cohort Study Based on the Primary Liver Cancer Registry in Korea Open
This is the first study to demonstrate that radiologic-pathologic discordance in patients with HCC who have undergone resection are significantly associated with worse survival. More accurate and appropriate preoperative evaluations are es…
View article: Antitumor role of L-arginine and argininosuccinate synthetase 1 in hepatocellular carcinoma: direct and immunological mechanisms
Antitumor role of L-arginine and argininosuccinate synthetase 1 in hepatocellular carcinoma: direct and immunological mechanisms Open
View article: Reply to correspondence on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma”
Reply to correspondence on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” Open
View article: Post-transplant cyclophosphamide plus anti-thymocyte globulin decreased serum IL-6 levels when compared with post-transplant cyclophosphamide alone after haploidentical hematopoietic stem cell transplantation
Post-transplant cyclophosphamide plus anti-thymocyte globulin decreased serum IL-6 levels when compared with post-transplant cyclophosphamide alone after haploidentical hematopoietic stem cell transplantation Open
Background Post-transplantation cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are common prophylactic strategies for graft-versus-host disease (GVHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). In…
View article: TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8<sup>+</sup>T cells
TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8<sup>+</sup>T cells Open
Summary Here we investigated the regulatory mechanisms of TCR-independent bystander activation and NK-like cytotoxicity of human memory CD8 + T cells. We found that TCR signals suppressed characteristic features of IL-15-induced CD8 + T-ce…
View article: Circulating cell-free mitochondrial DNA for diagnosing hepatocellular carcinoma and assessing prognosis: Editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma”
Circulating cell-free mitochondrial DNA for diagnosing hepatocellular carcinoma and assessing prognosis: Editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” Open
View article: Pathological Evaluation of the Therapeutic Effects of Argon Plasma Coagulation in Gastric Low-Grade Dysplasia
Pathological Evaluation of the Therapeutic Effects of Argon Plasma Coagulation in Gastric Low-Grade Dysplasia Open
Objectives: Gastric dysplasia is primarily treated using endoscopic resection. Although argon plasma coagulation (APC) is an alternative treatment for older patients or those with bleeding tendencies, studies have reported a higher rate of…
View article: Proportional Correlation Between Systemic Inflammation Response Index and Gastric Cancer Recurrence Time
Proportional Correlation Between Systemic Inflammation Response Index and Gastric Cancer Recurrence Time Open
Disease recurrence is the primary cause of death in patients with gastric cancer who have undergone complete surgical resection. No prognostic factors for recurrence, other than the tumor, node, metastasis (TNM) stage, have been establishe…
View article: Post-transplant cyclophosphamide plus anti-thymocyte globulin lowered serum IL-6 levels compared with post-transplant cyclophosphamide alone after haploidentical hematopoietic stem cell transplantation
Post-transplant cyclophosphamide plus anti-thymocyte globulin lowered serum IL-6 levels compared with post-transplant cyclophosphamide alone after haploidentical hematopoietic stem cell transplantation Open
Background: Post-transplant cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are both common prophylactic strategies for graft-versus-host disease (GVHD) in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Inte…
View article: Delayed Perihepatic Abscess in a Patient Who Underwent Surgical Resection of Duodenal Papilla
Delayed Perihepatic Abscess in a Patient Who Underwent Surgical Resection of Duodenal Papilla Open
View article: CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression
CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression Open
Background and Aims: HSCs contribute to HCC progression by regulating multiple factors. However, the entire immunoregulatory functions of HSCs are still obscure. Here, we aim to investigate whether HSCs impose CX 3 CR1 + macrophages to pro…
View article: Programmed Death 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma
Programmed Death 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer with poor prognosis. The lack of reliable biomarkers for early detection and accurate diagnosis and prognosis poses a significant challenge to its effective clinica…
View article: Comparison of Glecaprevir/Pibrentasvir and Sofosbuvir/Ledipasvir in Patients with Hepatitis C Virus Genotype 1 and 2 in South Korea
Comparison of Glecaprevir/Pibrentasvir and Sofosbuvir/Ledipasvir in Patients with Hepatitis C Virus Genotype 1 and 2 in South Korea Open
Both regimens had similar treatment completion rates, effectiveness, and safety profiles. Therefore, the SOF/LDV regimen can also be considered a viable DAA for the treatment of patients with genotype 1 or 2 chronic hepatitis C.
View article: Sugar-sweetened beverage consumption and metabolic dysfunction associated steatotic liver disease
Sugar-sweetened beverage consumption and metabolic dysfunction associated steatotic liver disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease. Accumulating evidence suggests a relationship between sugar-sweetened beverage (SSB) consumption and MASLD development; however, this relati…
View article: xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity Open
Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure. Here, we show…
View article: Prognostic Value of Erythroblastic Leukemia Viral Oncogene Homolog 2 and Neuregulin 4 in Hepatocellular Carcinoma
Prognostic Value of Erythroblastic Leukemia Viral Oncogene Homolog 2 and Neuregulin 4 in Hepatocellular Carcinoma Open
Although the roles of erythroblastic leukemia viral oncogene homolog 2 (ERBB2), neuregulin 4 (NRG4), and mitogen-inducible gene 6 (MIG6) in epidermal growth factor receptor signaling in hepatocellular carcinoma (HCC) and other malignancies…
View article: CT-based Hounsfield unit values reflect the degree of steatohepatitis in patients with low-grade fatty liver disease
CT-based Hounsfield unit values reflect the degree of steatohepatitis in patients with low-grade fatty liver disease Open
Background/Aims Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Ultrasound, the most used tool for diagnosing NAFLD, is operator-dependent and shows suboptimal performance in patients with mild steatosi…
View article: Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease Open
View article: The diagnostic value of circulating tumor DNA in hepatitis B virus induced hepatocellular carcinoma: a systematic review and meta-analysis
The diagnostic value of circulating tumor DNA in hepatitis B virus induced hepatocellular carcinoma: a systematic review and meta-analysis Open
Background/Aim: New biomarkers are urgently needed to aid in the diagnosis of early stage hepatocellular carcinoma (HCC). We performed a meta-analysis on the diagnostic utility of circulating tumor DNA (ctDNA) levels in patients with hepat…
View article: xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity Open
Obesity-mediated hypoxic stress underlies inflammatory responses, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure. We …