Hyun Yul Kim
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View article: Whole-Exome Sequencing Reveals Hippo Pathway Mutations as a Hallmark of Aggressive PTMC in Young Males
Whole-Exome Sequencing Reveals Hippo Pathway Mutations as a Hallmark of Aggressive PTMC in Young Males Open
Background Papillary thyroid microcarcinoma (PTMC) is typically associated with an excellent prognosis, and active surveillance is often appropriate for tumors smaller than 0.5 cm. However, surgical intervention is warranted when there is …
View article: Identification of Poor Prognostic Markers in Triple-Negative Breast Cancer Using Whole Exome Sequencing
Identification of Poor Prognostic Markers in Triple-Negative Breast Cancer Using Whole Exome Sequencing Open
Our findings highlight distinct mutational profiles and prognostic variants according to PD-L1 status in TNBC. ANGPTL5 and KIAA1549L variants may serve as potential prognostic markers for PD-L1-negative tumors. These results …
View article: Clinicopathological Factors Predicting Pathological Complete Response to Neoadjuvant Anti-HER2 Therapy in HER2-Positive Breast Cancer
Clinicopathological Factors Predicting Pathological Complete Response to Neoadjuvant Anti-HER2 Therapy in HER2-Positive Breast Cancer Open
Introduction: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have shown effectiveness against HER2-positive breast cancer. This makes neoadjuvant chemotherapy (NAC) a valuable option for treating both early and advanced…
View article: Changing trends in the management of ductal carcinoma in situ in Republic of Korea: a comprehensive analysis using Health Insurance Review and Assessment data [2009–2020]
Changing trends in the management of ductal carcinoma in situ in Republic of Korea: a comprehensive analysis using Health Insurance Review and Assessment data [2009–2020] Open
Our study sheds light on the changing landscape of DCIS treatment in South Korea incorporating perspectives from surgeons, plastic surgeons, and radiation oncologists. We observed an increase in the rates of lumpectomy and implant-based re…
View article: 3D Superclusters with Hybrid Bioinks for Early Detection in Breast Cancer
3D Superclusters with Hybrid Bioinks for Early Detection in Breast Cancer Open
The surface-enhanced Raman scattering (SERS) technique has garnered significant interest due to its ultrahigh sensitivity, making it suitable for addressing the growing demand for disease diagnosis. In addition to its sensitivity and unifo…
View article: An observational, prospective, open label, multicenter study to evaluate the safety and effectiveness of pegfilgrastim as secondary prophylaxis to decrease the incidence of febrile neutropenia in Korean female patients with breast cancer
An observational, prospective, open label, multicenter study to evaluate the safety and effectiveness of pegfilgrastim as secondary prophylaxis to decrease the incidence of febrile neutropenia in Korean female patients with breast cancer Open
View article: Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy
Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy Open
In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or org…
View article: Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer?
Is bone mineral density a prognostic factor in postmenopausal women with luminal A breast cancer? Open
Purpose: Several studies are concerned about the association between bone mineral density (BMD) and the risk of breast cancer in postmenopausal women, but it is controversial. Therefore, we evaluated whether BMD might be a risk factor for …
View article: Correction: Impact of 18F-FDG PET on the management of recurrent breast cancer: a meta-analysis
Correction: Impact of 18F-FDG PET on the management of recurrent breast cancer: a meta-analysis Open
View article: A retrospective study of factors affecting contralateral central-neck lymph node metastasis in unilateral papillary thyroid carcinoma
A retrospective study of factors affecting contralateral central-neck lymph node metastasis in unilateral papillary thyroid carcinoma Open
Male, extrathyroidal extension, and ipsilateral central neck lymph node metastasis may be considered for contralateral prophylactic central neck lymph node dissection. In the future, it is thought that more research on the recurrence rate …
View article: Male metaplastic breast cancer with poor prognosis: A case report
Male metaplastic breast cancer with poor prognosis: A case report Open
MBC is an aggressive and extremely rare breast cancer type. Further case reports are needed to determine the optimal treatment.
View article: Comparison of mutational profiles between triple-negative and hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancers in T2N0-1M0 stage: Implications of TP53 and PIK3CA mutations in Korean early-stage breast cancers
Comparison of mutational profiles between triple-negative and hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancers in T2N0-1M0 stage: Implications of TP53 and PIK3CA mutations in Korean early-stage breast cancers Open
Triple-negative breast cancer (TNBC) has higher loco-regional recurrence and visceral metastasis compared to other breast cancer subtypes; however, little is known about the molecular pathogenesis of TNBC. Therefore, we compared the mutati…
View article: Factors Affecting Pathologic Complete Remission in Patients with Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy
Factors Affecting Pathologic Complete Remission in Patients with Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy Open
Introduction: Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) is associated with improvement in survival outcomes. This study evaluated the pCR in patients with hormone receptor (HR)-positive and hum…
View article: Utility of sentinel lymph node biopsy in papillary thyroid microcarcinoma
Utility of sentinel lymph node biopsy in papillary thyroid microcarcinoma Open
Purpose: There are many studies on sentinel lymph node (SLN) biopsy in thyroid carcinoma but SLN biopsy (SLNB) in papillary thyroid carcinoma (PTC) remains open to debate. Therefore in this retrospective study, the usefulness of SLNB in th…
View article: Are the Outcomes of Breast Conservation Surgery Inferior to Those of Mastectomy in Patients with Stage II-IIIA Triple-Negative Breast Cancer?
Are the Outcomes of Breast Conservation Surgery Inferior to Those of Mastectomy in Patients with Stage II-IIIA Triple-Negative Breast Cancer? Open
Purpose: Breast conserving surgery (BCS) is generally not considered for breast cancer because of concerns about the poor prognosis of triple negative breast cancer (TNBC). We assessed the outcomes of BCS and mastectomy for patients with s…
View article: Prognostic value of SUVmax in breast cancer and comparative analyses of molecular subtypes
Prognostic value of SUVmax in breast cancer and comparative analyses of molecular subtypes Open
Background: To assess the prognostic capability of the maximum standardized uptake values (SUV max ) measured in the primary tumor and axillary lymph nodes (ALNs) by pretreatment fluorine-18-fluorodeoxyglucose positron emission tomography/…
View article: A comparative study of the clinical characteristics and outcomes of HR-positive HER2-negative breast cancer patients over and under 65 years old
A comparative study of the clinical characteristics and outcomes of HR-positive HER2-negative breast cancer patients over and under 65 years old Open
Purpose: The purpose of this study was to compare the clinical characteristics and outcomes of hormone receptor-positive (HR+) human epidermal growth factor 2-negative (HER2–) breast cancer among elderly patients (over 65 years old) and yo…
View article: Metastasis to breast from ovarian cancer and primary ovarian cancer concurrently diagnosis
Metastasis to breast from ovarian cancer and primary ovarian cancer concurrently diagnosis Open
Metastasis to breast from ovarian cancer is very rare, and it is very difficult to distinguish the primary breast cancer from the secondary one. In our case, a 61-year-old woman presented to the hospital with complaints of lower abdominal …
View article: Breast Cancer Statistics in Korea, 2018
Breast Cancer Statistics in Korea, 2018 Open
Breast cancer is the most common malignancy in Korean women, and its incidence continues to increase. The Korean Breast Cancer Society (KBCS) established a nationwide breast cancer database through its online enrollment program in 1996. Th…
View article: Thyrotropin suppression therapy for papillary thyroid carcinoma with a huge recurred neck lymph node
Thyrotropin suppression therapy for papillary thyroid carcinoma with a huge recurred neck lymph node Open
Differentiated thyroid cancer (DTC) originating from thyroid tissue is affected by thyrotropin (TSH). TSH suppression therapy is usually recommended after thyroidectomy in cases of DTC. A 57-year-old woman who harbored a very huge recurred…
View article: Comparison of the Mutation Profiles of Triple-Negative Breast Cancers and Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers at the T2N0-1M0 Stage
Comparison of the Mutation Profiles of Triple-Negative Breast Cancers and Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers at the T2N0-1M0 Stage Open
BackgroundTriple-negative breast cancer (TNBC) has higher loco-regional recurrence and visceral metastasis compared to other breast cancer subtypes; however, little is known about the molecular pathogenesis and therapeutic targets of TNBC.…
View article: What predicts better prognosis in elderly breast cancer patients?
What predicts better prognosis in elderly breast cancer patients? Open
In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an …
View article: Breast Cancer Statistics in Korea in 2017: Data from a Breast Cancer Registry
Breast Cancer Statistics in Korea in 2017: Data from a Breast Cancer Registry Open
This article describes the breast cancer statistics in Korea, including the incidence, type of surgical procedure, stage, and molecular subtype, using the Korean Breast Cancer Society (KBCS) and Korea Central Cancer Registry data. There we…
View article: Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid: A Case Report
Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid: A Case Report Open
Mucosa-associated lymphoid tissue lymphomas are a relatively recently recognized subset of B-cell non-Hodgkin's lymphomas. Generally, mucosa-associated lymphoid tissue lymphomas in the thyroid gland are known to have good prognosis, but re…
View article: Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis
Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis Open
According to our results, there was no significant difference in thrombus removal and recurrence-free rates between the CDT and ACA groups. ACA still has an important role in the treatment of DVT.
View article: Association between carotid artery stenosis and peripheral artery disease
Association between carotid artery stenosis and peripheral artery disease Open
We aimed to investigate the association between carotid artery stenosis and peripheral artery disease (PAD) by screening carotid ultrasonography (CUS). From January 2012 to December 2015, 231 consecutive patients who had undergone preopera…
View article: Erratum: Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry
Erratum: Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry Open
[This corrects the article on p. 1 in vol. 21, PMID: 29628978.].
View article: The Effects of Utilizing Smartphone Application Peer Support on Health Behavior and Body Mass Index among Breast Cancer Survivors
The Effects of Utilizing Smartphone Application Peer Support on Health Behavior and Body Mass Index among Breast Cancer Survivors Open
The SAPS has the potential to improve motivation for exercise, health behavior, and BMI of BCS. However, special efforts are required to encourage participants to complete the intervention and maintain long-term effects for future trials.
View article: Identifying breast cancer patients who require a double-check of preoperative core needle biopsy and postoperative surgical specimens to determine the molecular subtype of their tumor
Identifying breast cancer patients who require a double-check of preoperative core needle biopsy and postoperative surgical specimens to determine the molecular subtype of their tumor Open
Patients with moderate- to high-grade tumors or CEA ≥ 5 ng/mL are required a double-check to determine the molecular subtype of breast cancer.
View article: Thyroid Metastasis from Colon Cancer: a Case Report
Thyroid Metastasis from Colon Cancer: a Case Report Open