Hyunchae Sim
YOU?
Author Swipe
View article: Lipid Metabolic Reprogramming During Progression to Castration-resistant Prostate Cancer Identified by Quantitative Proteomics
Lipid Metabolic Reprogramming During Progression to Castration-resistant Prostate Cancer Identified by Quantitative Proteomics Open
These results suggest that fatty acids play a key role in HSPC's progression to CRPC, possibly indicating that CRPC cells themselves may generate fatty acids.
View article: Global Profiling of Lysine Lactylation in Prostate Cancer Cells
Global Profiling of Lysine Lactylation in Prostate Cancer Cells Open
This study presents the first comprehensive Kla landscape in PCa, suggesting its potential regulatory role in tumor progression. These findings provide a valuable resource for future studies and support Kla as a possible target for therape…
View article: p21-Activated Kinase 4 and Ischemic Acute Kidney Injury in Mice and Humans
p21-Activated Kinase 4 and Ischemic Acute Kidney Injury in Mice and Humans Open
Key Points p21-activated kinase 4 (PAK4) phosphorylates and inactivates GSH peroxidase 3 in the kidney after ischemia-reperfusion. Mice lacking PAK4 or treated with PAK4 proteolysis-targeting chimera were protected from kidney damage cause…
View article: Comparative Proteomics of ccRCC Cell Lines to Identify Kidney Cancer Progression Factors
Comparative Proteomics of ccRCC Cell Lines to Identify Kidney Cancer Progression Factors Open
From the global proteomics data detected in ccRCC, we propose 99 DEPs including vimentin as progression factors.
View article: Novel Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction
Novel Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction Open
The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease processes. However, it remains challenging to specify the study design for the subsequent integration s…
View article: Using Comparative Proteomics to Identify Protein Signatures in Clear Cell Renal Cell Carcinoma
Using Comparative Proteomics to Identify Protein Signatures in Clear Cell Renal Cell Carcinoma Open
Comparative proteomics analysis of ccRCC tissues provided new evidence of SERPINA3 association with ccRCC progression.
View article: Benzoylpaeoniflorin Activates Anti-Inflammatory Mechanisms to Mitigate Sepsis in Cell-Culture and Mouse Sepsis Models
Benzoylpaeoniflorin Activates Anti-Inflammatory Mechanisms to Mitigate Sepsis in Cell-Culture and Mouse Sepsis Models Open
Xuebijing injection (XBJI) (comprising of five herbs) is a widely used traditional Chinese medicine for sepsis treatment. However, the bioactive components of XBJI and the mechanisms responsible for its sepsis-mitigating action have not be…
View article: Benzoylpaeoniflorin activates anti-inflammatory mechanisms to mitigate sepsis in cell-culture and mouse sepsis models
Benzoylpaeoniflorin activates anti-inflammatory mechanisms to mitigate sepsis in cell-culture and mouse sepsis models Open
Background: Xuebijing injection (XBJI) (comprising of five herbs) is a widely used traditional Chinese medicine for sepsis treatment. However, the bioactive components of XBJI and the mechanisms responsible for its sepsis-mitigating action…
View article: Sulforaphane Alleviates Particulate Matter-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells
Sulforaphane Alleviates Particulate Matter-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells Open
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly, and oxidative damage to retinal pigment epithelial (RPE) cells plays a major role in the pathogenesis of AMD. Exposure to high levels of atmospheric par…