Explanipedia

Special Nursing Role-Taiwan National Accreditation Process (NAP) Certification Special Search and Rescue Team Medical Training Experience Open

Chris Chin, Chih-Yi Hsin, W. H. Hung, Peng Hao, Hsieh Yun FANG , et al. · 2025

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury Open

Z.M. Harris, Asawari Korde, Johad Khoury, Edward P. Manning, Gail Stanley , et al. · 2024

While delivery of supplemental oxygen is a life-saving therapy, exposure to high levels of oxygen, called hyperoxia, is associated with increased mortality in the intensive care unit (ICU). Hyperoxia leads to oxidant-mediated acute lung in…

P1637: PROTEOMIC PROFILING OF DIFFERENT ANTIPHOSPHOLIPID ANTIBODY-POSITIVE PHENOTYPES: RESULTS FROM ANTIPHOSPHOLIPID SYNDROME ALLIANCE FOR CLINICAL TRIALS AND INTERNATIONAL NETWORKING (APS ACTION) REGISTRY Open

Ayesha Butt, Rolando Garcia‐Milian, George Goshua, Sean X. Gu, John Hwa , et al. · 2023

Topic: 34. Thrombosis and vascular biology - Biology & Translational Research Background: Antiphospholipid syndrome (APS) is an autoimmune disease with thrombotic and obstetric complications arising via a model of immunothrombosis. Patient…

Association of renalase with clinical outcomes in hospitalized patients with COVID-19 Open

Basmah Safdar, Melinda Wang, Xiaohong Guo, Charles Cha, Hyung J. Chun , et al. · 2023

Renalase is a secreted flavoprotein with anti-inflammatory and pro-cell survival properties. COVID-19 is associated with disordered inflammation and apoptosis. We hypothesized that blood renalase levels would correspond to severe COVID-19 …

Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome Open

Inderjit Singh, Brooks P. Leitner, Yiwei Wang, Hanming Zhang, Phillip Joseph , et al. · 2023

Approximately 50% of patients who recover from the acute SARS‐CoV‐2 experience Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. The pathophysiological hallmark of PASC is characterized by impaired system oxygen extraction (EO 2…

LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis Open

Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang , et al. · 2022

Endothelial β‐arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia Open

Saejeong Park, Zhiyuan Ma, Georgia Zarkada, Irinna Papangeli, Sarin N Paluri , et al. · 2022

Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements. Many …

BMPR1A promotes ID2–ZEB1 interaction to suppress excessive endothelial to mesenchymal transition Open

Heon‐Woo Lee, Takaomi Adachi, Boryeong Pak, Saejeong Park, Xiaoyue Hu , et al. · 2022

Aims Components of bone morphogenetic protein (BMP) signalling have been implicated in both pathogenesis of pulmonary arterial hypertension (PAH) and endothelial-mesenchymal transition (EndoMT). In particular, the importance of BMP type 2 …

LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis Open

Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang , et al. · 2022

Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear. This study aimed to investigate the role of the long non-coding RNA (Ln…

LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis Open

Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang , et al. · 2022

Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetic cardiomyopathy (DCM), leading to early impaired myocardial compliance and late heart failure. However, the underlying mechanism remains largely…

Association of renalase with clinical outcomes in hospitalized patients with COVID-19 Open

Basmah Safdar, Melinda Wang, Xiaojia Guo, Charles Cha, Hyung J. Chun , et al. · 2022

Renalase is a secreted flavoprotein with anti-inflammatory and pro-cell survival properties. COVID-19 is associated with disordered inflammation and apoptosis. We hypothesized that blood renalase levels would correspond to severe COVID-19 …

Endothelial β-arrestins Regulate Mechanotransduction by the Type II Bone Morphogenetic Protein Receptor in Primary Cilia Open

Saejeong Park, Zhiyuan Ma, Georgia Zarkada, Irinna Papangeli, Sarin N. Paluri , et al. · 2022

Rationale Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic eleme…

Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A Open

Chris Mantsounga, Cadence Lee, Jade Neverson, Sheila Sharma, Abigail Healy , et al. · 2022

Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia‐Induced Lung Injury Open

Z.M. Harris, Ying Sun, John Joerns, Brian J. Clark, Buqu Hu , et al. · 2022

Aims . Studies have linked severe hyperoxia, or prolonged exposure to very high oxygen levels, with worse clinical outcomes. This study investigated the role of epidermal growth factor receptor (EGFR) in hyperoxia‐induced lung injury at ve…

Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era Open

Stephen Y. Wang, Prerak Juthani, Kelly Borges, Marcus Shallow, Akash Gupta , et al. · 2021

Proteomic Profiles in Patients with Thrombosis Due to COVID-19 Are Distinct from Non-COVID-19 Thrombosis Open

Daria Madeeva, Kelly Borges, Marcus Shallow, Prerak Juthani, Stephen Y. Wang , et al. · 2021

BACKGROUND. COVID-19 is a prothrombotic disease, characterized by endotheliopathy, hypercoagulability, and thromboembolic complications. We hypothesized that the pathogenesis of thromboembolism associated with COVID-19 might differ from th…

Hospitalisation among vaccine breakthrough COVID-19 infections Open

Prerak Juthani, Akash Gupta, Kelly Borges, Christina Price, Alfred Ian Lee , et al. · 2021

Chronic Thromboembolic Pulmonary Hypertension: the Bedside Open

Yuri Matusov, Inderjit Singh, Yen‐Rei Yu, Hyung J. Chun, Bradley A. Maron , et al. · 2021

Challenges in interpreting cytokine data in COVID-19 affect patient care and management Open

Stephen Y. Wang, Takehiro Takahashi, Alexander B. Pine, William Damsky, Michael Simonov , et al. · 2021

Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different disease contexts. We suggest mitigation strategies to improve the accuracy of cytokine data, as we learn f…

Association of obesity with venous thromboembolism and myocardial injury in COVID-19 Open

Stephen Y. Wang, Avinainder Singh, Maxwell Eder, Lina Vadlamani, Alfred Ian Lee , et al. · 2021

Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19 Open

Akash Gupta, Hyung J. Chun · 2021

Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19

Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19 Open

Carolina Lucas, Jon Klein, Maria E. Sundaram, Feimei Liu, Patrick Wong , et al. · 2021

Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection Open

Hyung J. Chun, Elias Coutavas, Alexander B. Pine, Alfred Ian Lee, Vanessa L. Yu , et al. · 2021

BACKGROUNDIndividuals recovering from COVID-19 frequently experience persistent respiratory ailments, which are key elements of postacute sequelae of SARS-CoV-2 infection (PASC); however, little is known about the underlying biological fac…

Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy Open

Matthew J. McConnell, Nao Kawaguchi, Reiichiro Kondo, Aurelio Sonzogni, Lisa Licini , et al. · 2021

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection Open

Lina Ma, Sanjaya Kumar Sahu, Marlene Cano, Vasanthan Kuppuswamy, Jamal Bajwa , et al. · 2021

Increased complement activation is observed in COVID-19 compared with non-COVID respiratory illness and is a key marker of organ failure.

Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients Open

Lindsay McAlpine, Adeel Zubair, Ilavarasy Maran, Pola Chojecka, Paul Lleva , et al. · 2021

Background and Purpose: Reports indicate an increased risk of ischemic stroke during coronavirus disease 2019 (COVID-19) infection. We aimed to identify patients with COVID-19 and ischemic stroke and explore markers of inflammation, hyperc…

Delayed production of neutralizing antibodies correlates with fatal COVID-19 Open

Carolina Lucas, Jon Klein, Maria E. Sundaram, Feimei Liu, Patrick Wong , et al. · 2021

PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19 Open

Stephen Yishu Wang, Alexander B. Pine, Michael Mankbadi, Chengyan Chang, Daria Madeeva , et al. · 2021

A neutrophil activation signature predicts critical illness and mortality in COVID-19 Open

Matthew L. Meizlish, Alexander B. Pine, Jason Bishai, George Goshua, Emily R. Nadelmann , et al. · 2021

Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We carried out proteomic profiling of plasma from cross-sectional and longitudinal cohort…

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection Open

Lina Ma, Sanjaya Kumar Sahu, Marlene Cano, Vasanthan Kuppuswamy, Jamal Bajwa , et al. · 2021

Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2 infection. However, it remains to be determined whether increased complement activation is a broad indicator of critical illness (and thus, no different in …

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