Hyung Kwon Byeon
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View article: Comparison of Diagnostic Yield Between Fine Needle Aspiration Cytology and Core Needle Biopsy in the Diagnosis of Thyroid Nodule
Comparison of Diagnostic Yield Between Fine Needle Aspiration Cytology and Core Needle Biopsy in the Diagnosis of Thyroid Nodule Open
Background/Objectives: This study aimed to evaluate the effectiveness of core needle biopsy (CNB) by comparing its diagnostic yield to fine needle aspiration cytology (FNAC) across primary and secondary examinations. Methods: This retrospe…
View article: Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer
Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer Open
Tongue cancer is a significant threat to human health due to its propensity to spread throughout the oral cavity and to other regions of the head and neck. The challenges posed by its high invasion, metastasis, and late clinical detection …
View article: Inside Front Cover: Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer (View 2/2025)
Inside Front Cover: Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer (View 2/2025) Open
View article: The Clinical Utility of Botulinum Toxin in the Field of Otolaryngology
The Clinical Utility of Botulinum Toxin in the Field of Otolaryngology Open
Botulinum toxin, originally identified in relation to botulism, has evolved from being considered a perilous pathogen to an invaluable therapeutic agent. First utilized by Alan Scott in 1977 to treat strabismus under the commercial name, O…
View article: Guidelines for the Use of Botulinum Toxin in Otolaryngology From the Korean Society of Laryngology, Phoniatrics and Logopedics Guideline Task Force
Guidelines for the Use of Botulinum Toxin in Otolaryngology From the Korean Society of Laryngology, Phoniatrics and Logopedics Guideline Task Force Open
The Korean Society of Laryngology, Phoniatrics and Logopedics created a task force to establish clinical practice guidelines for the use of botulinum toxin (BT) in otolaryngology. We selected 10 disease categories: spasmodic dysphonia, ess…
View article: A Case of Malignant Struma Ovarii with Cervical Papillary Thyroid Carcinoma
A Case of Malignant Struma Ovarii with Cervical Papillary Thyroid Carcinoma Open
Struma ovarii (SO) is a rare ovarian teratoma, which is diagnosed when thyroid tissue accounts for more than 50% of the teratoma.The majority of SO are benign, but malignant tumors have been reported in a small percentage of cases.Five per…
View article: A Case of Squamous Cell Carcinoma arising from an Odontogenic Keratocyst
A Case of Squamous Cell Carcinoma arising from an Odontogenic Keratocyst Open
Odontogenic keratocyst (OKC) accounts for 3-11% of all odontogenic cysts. OKC is a benign intra-osseous odontogenic tumor, but what makes this cyst special is its aggressive behavior and high recurrence rate. OKC is relatively aggressive c…
View article: Considerations for Balance Between Fundamental Treatment and Improvement of Quality of Life of Pediatric Thyroid Cancer Patient: Comparative Analysis With Adult Using Propensity Score Matching
Considerations for Balance Between Fundamental Treatment and Improvement of Quality of Life of Pediatric Thyroid Cancer Patient: Comparative Analysis With Adult Using Propensity Score Matching Open
Background Thyroid cancer is very rarely observed in children and adolescents, some reports have shown that the long-term outcome of treatment is better than that of adult patients, despite many treatment failures or a high risk of recurre…
View article: A Case of Spontaneous Cervical Hematoma caused by Parathyroid Adenoma
A Case of Spontaneous Cervical Hematoma caused by Parathyroid Adenoma Open
Spontaneous cervical hematomas could lead to life-threatening complications, and aneurysms, retopharyngeal abscesses, parathyroid adenomas, laryngeal cysts, and neurogenic tumors should be distinguished as possible underlying causes. Sympt…
View article: A Case of Solitary Metastatic Deposit in the Orbital Rim from Follicular Thyroid Cancer
A Case of Solitary Metastatic Deposit in the Orbital Rim from Follicular Thyroid Cancer Open
Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer, following papillary carcinoma. Metastasis to the orbital rim from FTC is very rare. We recently experienced a case of FTC with metastasis to the orbital rim in a …
View article: A Case of Multiple Pharyngocutaneous Fistulae Following Post-Operative Concurrent Chemoradiotherapy for Oropharyngeal Cancer
A Case of Multiple Pharyngocutaneous Fistulae Following Post-Operative Concurrent Chemoradiotherapy for Oropharyngeal Cancer Open
Pharyngocutaneous fistula is a readily encountered complication that occurs after surgery for laryngopharyngeal cancer. The development of pharyngocutaneous fistula increases hospitalization, delays postoperative adjuvant treatment, and ca…
View article: A Case of Chronic Tonsillitis Mimicking a Parapharyngeal Space Tumor
A Case of Chronic Tonsillitis Mimicking a Parapharyngeal Space Tumor Open
Parapharyngeal space (PPS) tumors are extremely rare, composing only 0.5% of all head and neck tumors. The PPS is shaped like an inverted pyramid bounded by the skull base superiorly and hyoid bone inferiorly. Recently, we experienced a 55…
View article: Targeting Fatty Acid Metabolism in Head and Neck Cancer
Targeting Fatty Acid Metabolism in Head and Neck Cancer Open
Reprogramming of cellular metabolism is an important, emerging, and universal hallmark of cancer which has received considerable attention during the recent era of cancer research. Cancer cells show characteristic alterations in glucose me…
View article: Effect of human acellular dermal matrix (MegadermTM) on infra-auricular depressed deformities, Frey’s syndrome, and first bite syndrome following parotidectomy: a multi-center prospective study
Effect of human acellular dermal matrix (MegadermTM) on infra-auricular depressed deformities, Frey’s syndrome, and first bite syndrome following parotidectomy: a multi-center prospective study Open
ADM implantation can effectively reduce the occurrence of Frey's syndrome, infra-auricular depressed deformity, and first bite syndrome after parotidectomy. ADM may be especially advantageous in complex parotidectomy cases when significant…
View article: Clinical Analysis of Laryngeal Tuberculosis: Recent 10 Years’ Experience in a Single Institution
Clinical Analysis of Laryngeal Tuberculosis: Recent 10 Years’ Experience in a Single Institution Open
Background and Objectives The overall incidence of laryngeal tuberculosis (LT) has generally decreased over the recent years, yet there is still a discrete population of patients newly diagnosed with the disease. This study is aimed to exa…
View article: ICG‐Guided Sentinel Lymph Node Sampling during Robotic Retroauricular Neck Dissection in cN0 Oral Cancer
ICG‐Guided Sentinel Lymph Node Sampling during Robotic Retroauricular Neck Dissection in cN0 Oral Cancer Open
In this study, we sought to evaluate the clinical feasibility of indocyanine green (ICG)–guided sentinel lymph node (SLN) sampling during robotic retroauricular neck dissection (RAND) in patients with cN0 oral cancer. Nine adult patients d…
View article: A Case of Unexpected Clinostomum complanatum Infection Initially Presenting as Foreign Body in Pharynx
A Case of Unexpected Clinostomum complanatum Infection Initially Presenting as Foreign Body in Pharynx Open
A 46-year old man visited our outpatient clinic with complaint of foreign body sensation in throat after consuming raw freshwater fish 5 days ago. Laryngoscopic examination revealed a motile worm attached on posterior pharyngeal wall. The …
View article: Oncologic and functional outcomes of salvage supracricoid partial laryngectomy
Oncologic and functional outcomes of salvage supracricoid partial laryngectomy Open
BACKGROUND: Supracricoid partial laryngectomy (SCL) can have a positive impact on patients' quality of life by circumventing dysphagia and voice problems resulting from creation of a permanent stoma after conventional total laryngectomy (T…
View article: Clinical Characteristics and Management of Saccular Cysts: A Single Institute Experience
Clinical Characteristics and Management of Saccular Cysts: A Single Institute Experience Open
Saccular cysts can be managed endoscopically using CO2 laser, without requiring an external approach. Therefore, an endoscopic approach should be actively considered for an optimal treatment outcome.
View article: Fibroblast growth factor receptor 3‐mediated reactivation of <scp>ERK</scp> signaling promotes head and neck squamous cancer cell insensitivity to <scp>MEK</scp> inhibition
Fibroblast growth factor receptor 3‐mediated reactivation of <span>ERK</span> signaling promotes head and neck squamous cancer cell insensitivity to <span>MEK</span> inhibition Open
Recurrent or metastatic head and neck squamous cell carcinoma ( HNSCC ) has been a longstanding challenge for head and neck oncologists, and current treatments still have limited efficacy. ERK is aberrantly overexpressed and activated in H…
View article: The Usefulness of Postoperative Direct Voice Therapy in Vocal Polyps
The Usefulness of Postoperative Direct Voice Therapy in Vocal Polyps Open
Background and Objectives Previous studies have suggested the usefulness and importance of postoperative voice therapy, for which there are indirect and direct methods. The aim of this study was to evaluate the efficacy of treatment accord…
View article: Publisher Correction: Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1/T2 glottic cancer
Publisher Correction: Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1/T2 glottic cancer Open
View article: Korean survey data reveals an association of chronic laryngitis with tinnitus in men
Korean survey data reveals an association of chronic laryngitis with tinnitus in men Open
The association between chronic laryngitis and tinnitus is not a well-studied topic, unlike the association of these two conditions with many other disorders. Cross-sectional data of 11,347 adults (males: 4,934; females: 6,413), who comple…
View article: HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer
HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer Open
HSPA5/GRP78/BiP plays an important role in cell survival or tumor progression. For these reasons, HSPA5 is an emerging therapeutic target in cancer development. Here we report that HSPA5 contributes to head and neck cancer (HNC) survival v…
View article: FOXO3 induces ubiquitylation of AKT through MUL1 regulation
FOXO3 induces ubiquitylation of AKT through MUL1 regulation Open
AKT (also known as protein kinase B, PKB) plays an important role in cell survival or tumor progression. For these reasons, AKT is an emerging target for cancer therapeutics. Previously our studies showed that mitochondrial E3 ubiquitin pr…
View article: Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1/T2 glottic cancer
Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1/T2 glottic cancer Open
View article: Epidemiological association of olfactory dysfunction with hearing loss and dysphonia in the Korean population
Epidemiological association of olfactory dysfunction with hearing loss and dysphonia in the Korean population Open
The aim of the study is to investigate the association between olfactory dysfunction (OD), hearing loss, and dysphonia.The cross-sectional data for 17,984 adults who completed the Korea National Health and Nutrition Examination Surveys (20…
View article: Recent progress of retroauricular robotic thyroidectomy with the new surgical robotic system
Recent progress of retroauricular robotic thyroidectomy with the new surgical robotic system Open
Objective Previously, we have reported the feasibility of retroauricular (RA) robotic thyroidectomy. Despite its promising surgical outcomes, there were certain intrinsic mechanical limitations inherent to the da Vinci Si System (Intuitive…
View article: Tracheal reconstruction with a free vascularized myofascial flap: preclinical investigation in a porcine model to human clinical application
Tracheal reconstruction with a free vascularized myofascial flap: preclinical investigation in a porcine model to human clinical application Open
View article: Impact of the Korean Diagnosis-Related Groups payment system on the outcomes of adenotonsillectomy: A single center experience
Impact of the Korean Diagnosis-Related Groups payment system on the outcomes of adenotonsillectomy: A single center experience Open