İbrahim Akın
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View article: ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome
ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome Open
Background Ajmaline challenge (AC) is used for diagnosing suspected Brugada syndrome (BS) in patients with unexplained syncope, survived cardiac arrest, or for family screening. Purpose To evaluate baseline ECG markers predicting a positiv…
View article: Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry
Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry Open
Background and aims Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy with defibrillation-function (CRT-D) are widely used in patients with life-threatening arrhythmias or heart failure. We aim to investi…
Promoting differentiation of human-induced pluripotent stem cells into sinoatrial node-like cells through programmed regulation of AMPK signalling pathway Open
Aims The differentiation of human-induced pluripotent stem cells (hiPSCs) into sinoatrial node (SAN)-like cells (SANLCs) remains challenged by complex differentiation protocols and low efficiency. This study aims to reveal the role of AMPK…
View article: Insulin-like growth factor binding protein 2 (IGFBP-2) as prognostic parameter in infarct-related cardiogenic shock
Insulin-like growth factor binding protein 2 (IGFBP-2) as prognostic parameter in infarct-related cardiogenic shock Open
In AMI-CS, elevated levels of IGFBP-2 were associated with higher mortality at 30 days and one year after admission. IGFBP-2 represents a promising prognostic biomarker and could add value to risk stratification in this high-risk patient c…
View article: Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis
Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis Open
Aims Patients with end-stage renal disease (ESRD) and atrial fibrillation present a challenge for thromboembolic prevention, given their elevated risks of both thromboembolism and bleeding. Anticoagulants carry a higher bleeding risk in th…
View article: Prevalence and Prognostic Impact of Coronary Chronic Total Occlusions in Patients With Cardiogenic Shock
Prevalence and Prognostic Impact of Coronary Chronic Total Occlusions in Patients With Cardiogenic Shock Open
Background Mortality in patients with cardiogenic shock (CS) remains high despite advanced treatment strategies in CS patients, underlining the need for the identification of predictors of prognosis in CS patients. Therefore, the present s…
View article: Coronary Chronic Total Occlusions Affect Long‐Term Prognosis in Heart Failure With Mildly Reduced Ejection Fraction
Coronary Chronic Total Occlusions Affect Long‐Term Prognosis in Heart Failure With Mildly Reduced Ejection Fraction Open
Background This study investigates the prevalence and prognostic impact of coronary chronic total occlusions (CTO) in patients with heart failure with mildly reduced ejection fraction (HFmrEF). Although coronary artery disease (CAD) repres…
View article: The phenomenon of dynamic change of cardiac troponin levels in patients with spontaneous intracerebral hemorrhage increases in-hospital mortality independent of macrovascular coronary artery disease
The phenomenon of dynamic change of cardiac troponin levels in patients with spontaneous intracerebral hemorrhage increases in-hospital mortality independent of macrovascular coronary artery disease Open
We suggest that a hs-cTnI dynamic is an expression of the acute myocardial 'hit' driven by sICH along the brain-heart axis leading to stroke-induced heart injury and not of ischemic myocardial infarction. IVH additionally contributes to th…
View article: Left Ventricular Ejection Fraction Predicts Outcomes in Different Subgroups of Patients Undergoing Coronary Angiography
Left Ventricular Ejection Fraction Predicts Outcomes in Different Subgroups of Patients Undergoing Coronary Angiography Open
Objectives: To evaluate the long-term prognostic value of left ventricular ejection fraction (LVEF) in consecutive patients undergoing invasive coronary angiography (CA). Background: LVEF is a key prognostic marker in cardiovascular diseas…
View article: Impact of sex on the outcome of troponin-positive patients with non-obstructive coronary arteries
Impact of sex on the outcome of troponin-positive patients with non-obstructive coronary arteries Open
The aim of this study was to investigate the prognostic impact of sex on in- and out-of-hospital adverse events in troponin-positive patients with non-obstructive coronary artery disease (CAD). 24,775 patients who underwent coronary angiog…
View article: Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry
Prognostic impact of uric acid levels in heart failure with mildly reduced ejection fraction: Insights from a large retrospective registry Open
Both elevated and low UA levels were associated with an increased risk of long-term all-cause mortality in patients with HFmrEF.
View article: One-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST Elevation
One-Year Outcomes of Coronary Angiography After Out-of-Hospital Cardiac Arrest Without ST Elevation Open
Importance Several randomized clinical trials (RCTs) assessed the effect of immediate vs delayed coronary angiography in patients with out-of-hospital cardiac arrest (OHCA) without ST-segment elevations and found no difference in short-ter…
View article: The Prognostic Impact of Kidney Dysfunction in Unselected Patients Undergoing Coronary Angiography: In What Subgroups Does Kidney Dysfunction Matter?
The Prognostic Impact of Kidney Dysfunction in Unselected Patients Undergoing Coronary Angiography: In What Subgroups Does Kidney Dysfunction Matter? Open
Background/Objectives: In recent decades, shifting demographics and advancements in treating cardiovascular disease have altered the types of patients receiving coronary angiography (CA). However, data investigating the impact of kidney dy…
View article: Impact of smoking in <scp>MINOCA</scp> patients
Impact of smoking in <span>MINOCA</span> patients Open
Background Considerable research has been conducted in recent years on patients afflicted with myocardial infarction with nonobstructive coronary disease (MINOCA), focussing on its prognosis, prevalence and predisposing risk factors. Never…
Catecholaminergic Polymorphic Ventricular Tachycardia: Advancing From Molecular Insights to Preclinical Models Open
Inherited cardiac channelopathies are linked to a heightened risk of sudden cardiac death. Despite evolving knowledge on different genes for these inherited conditions, for certain subtypes, such as catecholaminergic polymorphic ventricula…
View article: Wearable cardioverter defibrillator after ICD-system explantation: data from a multicenter registry
Wearable cardioverter defibrillator after ICD-system explantation: data from a multicenter registry Open
Data on the use of the wearable cardioverter defibrillator (WCD) among patients after cardiac implantable electronic device explantation of 1- to 3-chamber implantable cardioverter defibrillator systems (ICD) are sparse. Accordingly, sever…
View article: Different Mechanical Circulatory Support Strategies for Infarct-Related Cardiogenic Shock
Different Mechanical Circulatory Support Strategies for Infarct-Related Cardiogenic Shock Open
Bailout and escalated MCS therapy is associated with numerically higher 30-day mortality compared with upfront ECLS use only. Bailout MCS use is also associated with higher need for renal replacement therapy. (Extracorporeal Life Support i…
View article: Myocardial injury in spontaneous intracerebral hemorrhage is not predicted by prior cardiac disease or neurological status: results from the Mannheim Stroke database
Myocardial injury in spontaneous intracerebral hemorrhage is not predicted by prior cardiac disease or neurological status: results from the Mannheim Stroke database Open
Background and aims Elevated cardiac troponin (cTn) levels (representing myocardial injury) are frequently found in patients with spontaneous intracerebral hemorrhage (sICH). Overall, the relationship between sICH and elevated cTn levels i…
View article: Beta-Blockers and Long-Term Mortality in Takotsubo Syndrome
Beta-Blockers and Long-Term Mortality in Takotsubo Syndrome Open
Beta-blocker therapy in patients with TTS is associated with lower follow-up mortality, but not with lower TTS recurrence. (The GErman Italian Spanish Takotsubo Registry [GEIST]; NCT04361994).
Timing of acute decompensated heart failure in patients with heart failure and mildly reduced ejection fraction Open
This study investigates the prognosis of acute decompensated heart failure (ADHF) on admission (i.e., primary ADHF) as compared to ADHF onset during course of hospitalization (i.e., secondary ADHF) in patients hospitalized with heart failu…
View article: Prognostic Implications of Sex in Patients With Heart Failure With Mildly Reduced Ejection Fraction: Results From a Large‐Scaled Registry
Prognostic Implications of Sex in Patients With Heart Failure With Mildly Reduced Ejection Fraction: Results From a Large‐Scaled Registry Open
Background The study investigates the prognostic impact of sex and sex‐related differences in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). More data regarding the characterization of patients and…
View article: Sex differences and clinical outcomes, including ventricular tachyarrhythmias, of patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan
Sex differences and clinical outcomes, including ventricular tachyarrhythmias, of patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan Open
Background Women with heart failure with reduced ejection fraction (HFrEF) often experience worse clinical outcomes compared to men, including higher rates of mortality, hospitalization, and congestion. However, the effects of sacubitril/v…
A Rare Case: Isolated Metastasis of Laryngeal Cancer to the Breast in a Male Patient Open
Laryngeal cancer is one of the common cancer types, and distant organ metastasis is extremely rare. We present a 65-year-old male patient who received five cycles of cisplatin and radiotherapy after surgery for laryngeal cancer. In the pos…