Iwona Bukowska‐Ośko
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View article: Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers
Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers Open
Dysbiosis of the gut microbiota may contribute to metabolic dysregulation, intestinal barrier disruption, and inflammatory disorders. The objective was to identify gut-derived metabolites and leaky gut biomarkers linked to atopic dermatiti…
View article: Torque teno virus (TTV) Infection in Patients with Encephalitis
Torque teno virus (TTV) Infection in Patients with Encephalitis Open
Torque teno virus (TTV) is a ssDNA orphan virus belonging to the Anelloviridae family, but some recent studies suggested its possible involvement in central nervous system (CNS) pathology. We analyzed serum and cerebrospinal fluid samples …
View article: Lactoferrin as a Human Genome “Guardian”—An Overall Point of View
Lactoferrin as a Human Genome “Guardian”—An Overall Point of View Open
Structural abnormalities causing DNA modifications of the ethene and propanoadducts can lead to mutations and permanent damage to human genetic material. Such changes may cause premature aging and cell degeneration and death as well as sev…
View article: The Lactoferrin Phenomenon—A Miracle Molecule
The Lactoferrin Phenomenon—A Miracle Molecule Open
Numerous harmful factors that affect the human body from birth to old age cause many disturbances, e.g., in the structure of the genome, inducing cell apoptosis and their degeneration, which leads to the development of many diseases, inclu…
View article: CD8+ T-Cell Exhaustion Phenotype in Chronic Hepatitis C Virus Infection Is Associated With Epitope Sequence Variation
CD8+ T-Cell Exhaustion Phenotype in Chronic Hepatitis C Virus Infection Is Associated With Epitope Sequence Variation Open
Background and Aims During chronic hepatitis C virus (HCV) infection, CD8 + T-cells become functionally exhausted, undergoing progressive phenotypic changes, i.e., overexpression of “inhibitory” molecules such as PD-1 (programmed cell deat…
View article: Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases
Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases Open
The excessive formation of reactive oxygen species (ROS) and impairment of defensive antioxidant systems leads to a condition known as oxidative stress. The main source of free radicals responsible for oxidative stress is mitochondrial res…
View article: The Immunological Role of the Placenta in SARS-CoV-2 Infection—Viral Transmission, Immune Regulation, and Lactoferrin Activity
The Immunological Role of the Placenta in SARS-CoV-2 Infection—Viral Transmission, Immune Regulation, and Lactoferrin Activity Open
A pandemic of acute respiratory infections, due to a new type of coronavirus, can cause Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) and has created the need for a better understanding of the clinical, epidemiological, and pathological…
View article: Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa
Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa Open
Objectives: Research suggests reciprocal crosstalk between the host and gut bacteria. This study evaluated the interaction between gut microbiota and arterial blood pressure (BP) in rats. Methods: Continuous telemetry recordings of BP were…
View article: Search for viral agents in cerebrospinal fluid in patients with multiple sclerosis using real-time PCR and metagenomics
Search for viral agents in cerebrospinal fluid in patients with multiple sclerosis using real-time PCR and metagenomics Open
Multiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system of unclear etiology, but there is some evidence that viral infections could be responsible for triggering autoimmune mechanisms again…
View article: Search for Viral Infections in Cerebrospinal Fluid From Patients With Autoimmune Encephalitis
Search for Viral Infections in Cerebrospinal Fluid From Patients With Autoimmune Encephalitis Open
Background It has been reported that virus-mediated brain tissue damage can lead to autoimmune encephalitis (AE) characterized by the presence of antibodies against neuronal surface antigens. In the study, we investigate the presence of vi…
View article: Next-generation sequencing in the diagnosis of viral encephalitis: sensitivity and clinical limitations
Next-generation sequencing in the diagnosis of viral encephalitis: sensitivity and clinical limitations Open
Identification of pathogens causing viral encephalitis remains challenging, and in over 50% of cases the etiologic factor remains undetermined. Next-generation sequencing (NGS) based metagenomics has been successfully used to detect novel …
View article: Expression of programmed cell death protein 1 and T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus infection and in subjects who spontaneously cleared the virus
Expression of programmed cell death protein 1 and T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 on peripheral blood CD4+CD8+ double positive T cells in patients with chronic hepatitis C virus infection and in subjects who spontaneously cleared the virus Open
Chronic hepatitis C virus (HCV) infection is characterized by increased proportion of CD4+CD8+ double positive (DP) T cells, but their role in this infection is unclear. In chronic hepatitis C, immune responses to HCV become functionally e…
View article: Corrigendum: Next-generation Sequencing Analysis of New Genotypes Appearing During Antiviral Treatment of Chronic Hepatitis C Reveals that These Are Selected from Pre-existing Minor Strains
Corrigendum: Next-generation Sequencing Analysis of New Genotypes Appearing During Antiviral Treatment of Chronic Hepatitis C Reveals that These Are Selected from Pre-existing Minor Strains Open
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our princi…
View article: Human Pegivirus in Patients with Encephalitis of Unclear Etiology, Poland
Human Pegivirus in Patients with Encephalitis of Unclear Etiology, Poland Open
Human pegivirus (HPgV), previously called hepatitis G virus or GB virus C, is a lymphotropic virus with undefined pathology. Because many viruses from the family Flaviviridae, to which HPgV belongs, are neurotropic, we studied whether HPgV…
View article: Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center
Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center Open
Molecular characterization of early hepatitis C virus (HCV) infection remains rare. Ten out of 78 patients of a hematology/oncology center were found to be HCV RNA positive two to four months after hospitalization. Only two of the ten pati…
View article: Viral etiologies in adult patients with encephalitis in Poland: A prospective single center study
Viral etiologies in adult patients with encephalitis in Poland: A prospective single center study Open
Encephalitis is a severe neurological syndrome associated with high morbidity and mortality as well as long-term neurological sequelae. Despite being an important public health problem, very few extensive population-based studies were cond…
View article: A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting
A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting Open
We demonstrated transmission of TBEV by transplantation of solid organs. In such a setting, TBEV infection may be fatal, probably due to pharmacological immunosuppression. Organ donors should be screened for TBEV when coming from or visiti…
View article: Spouse-to-Spouse Transmission and Evolution of Hypervariable Region 1 and 5’ Untranslated Region of Hepatitis C Virus Analyzed by Next-Generation Sequencing
Spouse-to-Spouse Transmission and Evolution of Hypervariable Region 1 and 5’ Untranslated Region of Hepatitis C Virus Analyzed by Next-Generation Sequencing Open
Hepatitis C virus (HCV) transmission between spouses remains poorly characterized, largely due to the limited availability of samples from the early stage of infection, as well as methodological constraints. A fifty-eight year-old male dev…
View article: No evidence of West Nile virus infection among Polish patients with encephalitis
No evidence of West Nile virus infection among Polish patients with encephalitis Open
West Nile virus (WNV) infection usually causes mild febrile illness, but in a small proportion of patients it can lead to encephalitis. Epidemiological studies of WNV indicate fast spread of infection worldwide and in Europe, but there hav…
View article: Next-generation sequencing (NGS) in the identification of encephalitis-causing viruses: Unexpected detection of human herpesvirus 1 while searching for RNA pathogens
Next-generation sequencing (NGS) in the identification of encephalitis-causing viruses: Unexpected detection of human herpesvirus 1 while searching for RNA pathogens Open
In summary, it seems that NGS preceded by nucleic acid amplification could supplement currently used diagnostic methods in encephalitis.
View article: Genetic Variability of Hepatitis C Virus (HCV) 5’ Untranslated Region in HIV/HCV Coinfected Patients Treated with Pegylated Interferon and Ribavirin
Genetic Variability of Hepatitis C Virus (HCV) 5’ Untranslated Region in HIV/HCV Coinfected Patients Treated with Pegylated Interferon and Ribavirin Open
Association between hepatitis C virus (HCV) quasispecies and treatment outcome among patients with chronic hepatitis C has been the subject of many studies. However, these studies focused mainly on viral variable regions (E1 and E2) and us…