Gualtiero I. Colombo
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View article: The italian national genomic strategy: current status, challenges, and future perspectives in clinical practice and public health
The italian national genomic strategy: current status, challenges, and future perspectives in clinical practice and public health Open
View article: Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction
Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction Open
View article: Beyond plaque segmentation: a combined radiomics-deep learning approach for automated CAD-RADS classification
Beyond plaque segmentation: a combined radiomics-deep learning approach for automated CAD-RADS classification Open
Introduction Coronary Artery Disease (CAD) is a leading cause of global mortality, accurate stenosis grading is crucial for treatment planning, it currently requires time-consuming manual assessment and suffers from interobserver variabili…
View article: An in vitro model for cardiac organoid production: The combined role of geometrical confinement and substrate stiffness
An in vitro model for cardiac organoid production: The combined role of geometrical confinement and substrate stiffness Open
View article: A Radiomics-Based Machine Learning Approach for Coronary Stenosis Assessment from Coronary Computed Tomography Angiography
A Radiomics-Based Machine Learning Approach for Coronary Stenosis Assessment from Coronary Computed Tomography Angiography Open
View article: Granulocyte colony-stimulating factor for stem cell mobilisation in acute myocardial infarction: a randomised controlled trial
Granulocyte colony-stimulating factor for stem cell mobilisation in acute myocardial infarction: a randomised controlled trial Open
Background To determine whether granulocyte colony-stimulating factor (G-CSF) improves clinical outcomes after large ST-elevation myocardial infarction (STEMI) when administered early in patients with left ventricular (LV) dysfunction afte…
View article: Deciphering Abdominal Aortic Diseases Through T‐Cell Clonal Repertoire of Perivascular Adipose Tissue
Deciphering Abdominal Aortic Diseases Through T‐Cell Clonal Repertoire of Perivascular Adipose Tissue Open
Background Recent studies suggest that immune‐mediated inflammation of perivascular adipose tissue of abdominal aortic aneurysms (AAAs) contributes to disease development and progression. Whether the perivascular adipose tissue of AAA is c…
View article: Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis
Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Fondazione Umberto Veronesi (Research Grant 2011-12 to GIC) Fondazione Gigi e Pupa Ferrari ONLUS (FPF-14 to PP) Background Aortic valve sclerosis (AVSc) …
View article: Determinants of Carotid Wall Echolucency in a Cohort of European High Cardiovascular Risk Subjects: A Cross-Sectional Analysis of IMPROVE Baseline Data
Determinants of Carotid Wall Echolucency in a Cohort of European High Cardiovascular Risk Subjects: A Cross-Sectional Analysis of IMPROVE Baseline Data Open
Echolucency, a measure of plaque instability associated with increased cardiovascular risk, can be assessed in both the carotid plaque and the plaque-free common carotid intima–media (IM) complex as a gray-scale median (plaque-GSM and IM-G…
View article: CAD-RADS scoring of coronary CT angiography with Multi-Axis Vision Transformer: A clinically-inspired deep learning pipeline
CAD-RADS scoring of coronary CT angiography with Multi-Axis Vision Transformer: A clinically-inspired deep learning pipeline Open
View article: Whole-Blood Transcriptome Unveils Altered Immune Response in Acute Myocardial Infarction Patients With Aortic Valve Sclerosis
Whole-Blood Transcriptome Unveils Altered Immune Response in Acute Myocardial Infarction Patients With Aortic Valve Sclerosis Open
BACKGROUND: Aortic valve sclerosis (AVSc) presents similar pathogenetic mechanisms to coronary artery disease and is associated with short- and long-term mortality in patients with coronary artery disease. Evidence of AVSc-specific pathoph…
View article: Deciphering abdominal aortic diseases through T-cell clonal repertoire of perivascular adipose tissue
Deciphering abdominal aortic diseases through T-cell clonal repertoire of perivascular adipose tissue Open
Recent studies suggested that immune-mediated inflammation of perivascular adipose tissue (PVAT) of abdominal aortic aneurysms (AAA) contributes to disease development and progression. Whether the PVAT of AAA is characterized by a specific…
View article: Dataset related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis"
Dataset related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis" Open
This record contains raw data related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis" Abstract Background: Aortic valve sclerosis (AVSc) present…
View article: Dataset related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis"
Dataset related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis" Open
This record contains raw data related to the article "Whole-blood transcriptome unveils altered immune response in acute myocardial infarction patients with aortic valve sclerosis" Abstract Background: Aortic valve sclerosis (AVSc) present…
View article: PB0124 Treatment with PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia Lowers Plasma Levels of Platelet Activating Factor and its Precursors: A Combined Metabolomic and Lipidomic Approach
PB0124 Treatment with PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia Lowers Plasma Levels of Platelet Activating Factor and its Precursors: A Combined Metabolomic and Lipidomic Approach Open
View article: Treatment with PCSK9 inhibitors in patients with familial hypercholesterolemia lowers plasma levels of platelet activating factor and its precursors: A combined metabolomic and lipidomic approach
Treatment with PCSK9 inhibitors in patients with familial hypercholesterolemia lowers plasma levels of platelet activating factor and its precursors: A combined metabolomic and lipidomic approach Open
View article: Blood-based transcriptional signatures at hospital admission are associated with cardiac magnetic resonance markers of STEMI prognosis
Blood-based transcriptional signatures at hospital admission are associated with cardiac magnetic resonance markers of STEMI prognosis Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Italian Ministry of Health. Background While mortality following ST-segment elevation myocardial infarction (STEMI) is declining, the number o…
View article: CAD-RADS scoring of coronary CT angiography with Multi-Axis Vision Transformer: a clinically-inspired deep learning pipeline
CAD-RADS scoring of coronary CT angiography with Multi-Axis Vision Transformer: a clinically-inspired deep learning pipeline Open
The standard non-invasive imaging technique used to assess the severity and extent of Coronary Artery Disease (CAD) is Coronary Computed Tomography Angiography (CCTA). However, manual grading of each patient's CCTA according to the CAD-Rep…
View article: Identification of an inflammation-associated psychosis onset subgroup by applying unsupervised machine learning to whole-blood expression levels of immune gene transcripts
Identification of an inflammation-associated psychosis onset subgroup by applying unsupervised machine learning to whole-blood expression levels of immune gene transcripts Open
Nowadays, the lack of quantitative criteria to resolve the diagnostic heterogeneity of psychotic onsets limits the development of safer and more effective treatments. Therefore, the hypothesis to integrate multimodal data to uncover biolog…
View article: 337 RECLASSIFICATION OF GENETIC VARIANTS WITH PREVIOUSLY UNRECOGNIZED PATHOGENIC ROLE IN PATIENTS WITH INHERITED CARDIAC CONDITIONS
337 RECLASSIFICATION OF GENETIC VARIANTS WITH PREVIOUSLY UNRECOGNIZED PATHOGENIC ROLE IN PATIENTS WITH INHERITED CARDIAC CONDITIONS Open
Introduction In the last years, genetic testing for inherited cardiac conditions (ICCs) is expanded and evolved at an incredible rate. This tool may inform treatment options and lifestyle choices to avoid arrhythmia triggers. Furthermore, …
View article: Spectrum of rare and common genetic variants in arrhythmogenic cardiomyopathy
Spectrum of rare and common genetic variants in arrhythmogenic cardiomyopathy Open
Background Arrhythmogenic cardiomyopathy (ACM) is a rare inherited cardiac disorder, whose genetic cause is elusive in about 50% of cases. ACM pathogenic mutations mainly involve desmosomal genes (PKP2, JUP, DSP, DSG2, DSC2). ACM presents …
View article: Reinterpretation of variant of unknown significance in the clinical setting of inherited cardiac conditions
Reinterpretation of variant of unknown significance in the clinical setting of inherited cardiac conditions Open
Introduction In the last years, genetic testing for inherited cardiac conditions (ICCs) is expanded and evolved at an incredible rate. This tool may inform treatment options and lifestyle choices to avoid arrhythmia triggers. Furthermore, …
View article: Deep learning applied to facial features for prediction of high risk coronary atherosclerosis at cardiac CT: preliminary data from LOMBROSO Trial
Deep learning applied to facial features for prediction of high risk coronary atherosclerosis at cardiac CT: preliminary data from LOMBROSO Trial Open
Background Cardiac computed tomography (CT) emerged as an accurate tool for non-invasive evaluation of coronary artery disease (CAD), being able to identify high risk non-calcified atherosclerosis. Identification of high risk CAD in its as…
View article: Effects of RAGE Deletion on the Cardiac Transcriptome during Aging
Effects of RAGE Deletion on the Cardiac Transcriptome during Aging Open
Cardiac aging is characterized by increased cardiomyocyte hypertrophy, myocardial stiffness, and fibrosis, which enhance cardiovascular risk. The receptor for advanced glycation end-products (RAGE) is involved in several age-related diseas…
View article: Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients Open
Arrhythmogenic cardiomyopathy (ACM) is a rare inherited disorder, whose genetic cause is elusive in about 50–70% of cases. ACM presents a variable disease course which could be influenced by genetics. We performed next-generation sequencin…
View article: Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation
Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation Open
Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hy…
View article: Whole-Blood Transcriptional Profiles Enable Early Prediction of the Presence of Coronary Atherosclerosis and High-Risk Plaque Features at Coronary CT Angiography
Whole-Blood Transcriptional Profiles Enable Early Prediction of the Presence of Coronary Atherosclerosis and High-Risk Plaque Features at Coronary CT Angiography Open
Existing tools to estimate cardiovascular (CV) risk have sub-optimal predictive capacities. In this setting, non-invasive imaging techniques and omics biomarkers could improve risk-prediction models for CV events. This study aimed to ident…
View article: Trained Immunity in Perivascular Adipose Tissue of Abdominal Aortic Aneurysm—A Novel Concept for a Still Elusive Disease
Trained Immunity in Perivascular Adipose Tissue of Abdominal Aortic Aneurysm—A Novel Concept for a Still Elusive Disease Open
Abdominal aortic aneurysm (AAA) is a chronic, life-threatening vascular disease whose only therapeutic option is a surgical repair to prevent vessel rupture. The lack of medical therapy results from an inadequate understanding of the etiop…
View article: Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting
Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting Open
Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative…
View article: Dataset related to the article :"Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting"
Dataset related to the article :"Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting" Open
This record contains raw data related to the article:" Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting" Abstract Coronary artery bypass graft (CABG) surgery still represents the gold …