Explanipedia

BCG vaccination: historical role, modern applications, and future perspectives in tuberculosis and beyond Open

Анна Старшинова, I. V. Kudryavtsev, Artem Rubinstein, I. F. Dovgalyuk, Anastasia Kulpina , et al. · 2025

Tuberculosis (TB) remains a fatal disease primarily transmitted through airborne droplets, with children who are the most susceptible, particularly in the areas with poor tuberculosis control. The BCG vaccine, developed by Albert Calmette …

Immunological Disorders: Gradations and the Current Approach in Laboratory Diagnostics Open

Анна Старшинова, А. А. Савченко, А. Г. Борисов, I. V. Kudryavtsev, Artem Rubinstein , et al. · 2025

Currently, understanding the immune response, its abnormalities, and its diagnostic possibilities is a key point in the management of patients with various diseases, from infectious to oncological ones. The aim of this review was to analyz…

Lessons Learned from the COVID-19 Pandemic: Simulation of the Tuberculosis Epidemic as a Function of Population Coverage with Screening Open

Анна Старшинова, I. F. Dovgalyuk, N. N. Osipov, D.А. Kudlаy · 2023

The COVID-19 pandemic has led to the discontinuation of many support programs for tuberculosis patients worldwide, and lower coverage of population with screening for tuberculosis. The objective : To build a model describing the spread of …

Bedaquiline Efficacy in the Russian Federation: Meta-analysis with a Random Effects Model Open

Анна Старшинова, I. F. Dovgalyuk, N. N. Osipov, D.А. Kudlаy · 2023

The objective: to determine the rate of treatment success in MDR and XDR pulmonary tuberculosis patients when treated with chemotherapy regimens containing bedaquiline based on a meta-analysis using mathematical modeling. Subjects and Meth…

Tuberculosis prevalence in children in the Northwestern Federal District of Russia before and after COVID-19 pandemic: prognosis and epidemiological models Open

I. F. Dovgalyuk, D.А. Kudlаy, Анна Старшинова · 2023

Aim. To assess changes in the epidemic indicators of tuberculosis infection (TB) in children in the Northwestern Federal District of Russia before and after the COVID-19 pandemic based on mathematical modeling and forecasting. Materials an…

Tuberculosis in Adults and Children in the Northwestern Federal District: Changes in Epidemiological Rates and Criteria for Their Assessment Open

Анна Старшинова, I. F. Dovgalyuk, D.А. Kudlаy, M. V. Beltyukov, P. K. Yаblonskiy · 2022

The epidemic situation is monitored by numerous rates that may not reflect it objectively which will subsequently lead to higher incidence rates and severe forms of tuberculosis in both adults and children in the regions with the most unfa…

Immunotherapy in the Treatment of COVID-19 Open

Anna Malkova, Анна Старшинова, Igor Kudryavtsev, I. F. Dovgalyuk, Yulia Zinchenko , et al. · 2021

The high mortality rate in COVID-19 can be explained by the development of a hyperinflammatory syndrome, characterized by a cytokine storm and extensive thrombus formation. The main direction for preventing the development of hyperinflamma…

Prospects for a COVID-19 treatment: review Open

Анна Старшинова, Е. А. Кушнарева, D.А. Kudlаy, I. F. Dovgalyuk · 2020

In the context of the new coronavirus infection spreading it is particularly relevance to obtain information on the clinical course, diagnostic possibilities and features of the COVID-19 treatment. By May 2020 in the world more than 4 mill…

New Coronaviral Infection: Features of Clinical Course, Capabilities of Diagnostics, Treatment and Prevention in Adults and Children Open

Анна Старшинова, Е. А. Кушнарева, Анна Малкова, I. F. Dovgalyuk, D.А. Kudlаy · 2020

First cases of new coronaviral infection were reported in Wuhan, Hubei Province, China in December 2019. The infection had caused the death of more than 100,000 people worldwide by the beginning of April 2020. This review analysed the char…

RECOMBINANT TUBERCULOSIS ALLERGEN: 10 YEARS OF EXPERIENCE WITH THE TEST IN CHILDREN AND ADOLESCENTS IN THE RUSSIAN FEDERATION (META-ANALYSIS DATA) Open

D.А. Kudlаy, Анна Старшинова, I. F. Dovgalyuk · 2020

EFFICACY OF NEW METHODS OF TUBERCULOSIS INFECTION IMMUNODIAGNOSTICS IN THE RUSSIAN FEDERATION Open

Анна Старшинова, D.А. Kudlаy, I. F. Dovgalyuk, Natalia Basantsova, Yulia Zinchenko , et al. · 2019

IMMUNODIAGNOSTICS OF TUBERCULOSIS: 10-YEAR EXPERIENCE OF USING IMMUNOLOGICAL TESTS IN RUSSIA Open

Анна Старшинова, I. F. Dovgalyuk, P. K. Yаblonskiy · 2019

The introduction of a new generation of immunological tests based on in vitro or in vivo reactions using specific ЕSAT-6 and CFP-10 peptides allowed changing the understanding of the diagnosis of latent tuberculosis infection, as well as i…

The effect of human leukocyte Antigens-DRB1 alleles on development of different tuberculosis forms in children Open

Анна Старшинова, I. F. Dovgalyuk, A. S. Berkos, Yulia Ovchinnikova, Л. Н. Бубнова , et al. · 2018

As a result of the study, statistically significant differences in the distribution of HLA-DRB1* alleles in children with TB in comparison with a control group for *01, *03, *11, *13, *07, *15, and *16 alleles were found. It may indicate t…

THE EFFICIENCY OF USING THE MEDICATION COMBING 150 MG OF ISONIAZID , 375 MG OF PYRAZINA MIDE , 150 MG OF RI FAMPICIN IN THE TREATMEN T OF RESPIRATOR Y TUBERCULOSIS IN CHILDREN Open

Yu. E. Ovchinnikova, A. A. Starshikova, I. F. Dovgalyuk · 2017

The main problem for treatment of children with various manifestations of tuberculosis is the lack of pediatric dosages of anti-tuberculosis drugs. Considering the current problems when providing treatment it is important to use combined m…

RESULTS OF IMMUNOLOGICAL TESTING OF NEW GENERATION IN CHILDREN UNDER MASSIVE VACCINATION AGAINST TUBERCULOSIS Open

Анна Старшинова, Semion Ananiev, Yu. E. Ovchinnikova, Н. В. Корнева, I. F. Dovgalyuk · 2017

Development of new methods of immune diagnostics of tuberculous infection and their introduction into tuberculosis control practice have changed approaches to diagnostics of tuberculosis in Russia. Along with world recognized IGRA-tests th…

FEATURES OF HLA-DRB1 AND DQB1 ALLELES DISTRIBUTION IN CHILDREN WITH GENERALIZED TUBERCULOSIS Open

Анна Старшинова, A. S. Berkos, Valentina Vatutina, Yu. E. Ovchinnikova, Yu. V. Sokolova , et al. · 2017

So far, there is no clear understanding for the reasons causing tuberculosis generalization in children. Development of generalized infection could be also determined by some features of immune response which may depend on genetic markers.…

EFFICIENCY OF PNEUMOCOCCAL VACCINE IN CHILDREN WITH DIFFERENT PATTERNS OF TUBERCULOSIS INFECTION Open

I. F. Dovgalyuk, Т С Дрозденко, Анна Старшинова, Н. В. Корнева, S. M. Kharith · 2017

Concomitant infection is known to decrease non-specific immunity levels, thus negatively affecting clinical outcomes in tuberculosis patients. Development of specific immune response against most common pediatric infections, e.g., pneumoco…

PROGNOSTIC FACTORS FOR TUBERCULOSIS DEVELOPMENT IN CHILDREN WITH LATENT TUBERCULOSUS INFECTION Open

Н. В. Корнева, Анна Старшинова, Semen Ananiev, Yu. E. Ovchinnikova, I. F. Dovgalyuk · 2016

Goal of the study: to detect specific immune response in children with latent tuberculous infection and define factors to forecast the development of the active disease in this group.Materials and methods. The changes in clinical, X-ray an…

INNOVATIVE APPROACHES TO TUBERCULOSIS DETECTION AND DIAGNOSTICS IN CHILDREN Open

Yu. P. Chugaev, T. E. Tyul'kova, D. N. Golubev, O. V. Moiseeva, I. F. Dovgalyuk , et al. · 2015

The articles presents materials of the three defended and approved doctor’s dissertations, devoted to individual approaches to children ill with tuberculosis and having the risks of developing tuberculosis depending on social conditions, s…

INFLUENCE OF HLA-DRB1* ALLELIC SETS ON THE DEVELOPMENT OF TUBERCULOSIS IN CHILDREN Open

Анна Старшинова, Н. В. Корнева, I. F. Dovgalyuk, М. В. Павлова, Irina Pavlovа , et al. · 2015

According to the WHO data, tuberculosis still represents a serious public health problem worldwide. Deterioration of socio-economic conditions in the population complicates epidemic situation for tuberculosis inRussia, thus leading to incr…

Clinical and epidemiological characteristics of registered childhood tuberculosis cases in the North-Western Region of Russia when introducing a tuberculosis diagnosis complex using diaskintest and multislice spiral computed tomography Open

I. F. Dovgalyuk, Н. В. Корнева, Анна Старшинова, Yu. E. Ovchinnikovа, S. M. Ananyev · 2015

The paper analyzes changes in the pattern of clinical forms of registered tuberculosis cases, in the proportion of detected complications and phases of the specific process in children in 2007 to 2012. The findings were compared with regis…

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