Irwin Goldstein
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View article: (313) Sexual Symptoms and Biologic Pathophysiologies of Post-SSRI Sexual Dysfunction: A 15 Year Review
(313) Sexual Symptoms and Biologic Pathophysiologies of Post-SSRI Sexual Dysfunction: A 15 Year Review Open
Introduction Sexual side effects from a selective serotonin reuptake inhibitor (SSRI)/serotonin and norepinephrine reuptake inhibitor (SNRI) typically resolve upon discontinuation. Post-SSRI Sexual Dysfunction (PSSD) is identified in patie…
View article: (045) A Protocol for Managing Salvage IPPs Using LiSWT Combined With Systemic Antibiotics
(045) A Protocol for Managing Salvage IPPs Using LiSWT Combined With Systemic Antibiotics Open
Introduction The prevalence of infection with inflatable penile implant (IPP) varies from 1-3%, usually managed by device explantation, and if appropriate, salvage surgery. Despite the salvage, about 20% of these cases remain infected requ…
View article: (023) Monitored Hormone Therapy for Sexual Dysfunction in Breast Cancer Survivors: Are Benefits Greater Than Risks?
(023) Monitored Hormone Therapy for Sexual Dysfunction in Breast Cancer Survivors: Are Benefits Greater Than Risks? Open
Introduction Women with breast cancer and symptoms of genitourinary syndrome of menopause (GSM) frequently have sexual dysfunction that can adversely affect quality of life. Both patients and practitioners are apprehensive regarding the us…
View article: The use of tirzepatide to successfully treat persistent genital arousal disorder/genitopelvic dysesthesia: a case report
The use of tirzepatide to successfully treat persistent genital arousal disorder/genitopelvic dysesthesia: a case report Open
Introduction Persistent genital arousal disorder/genitopelvic dysesthesia (PGAD/GPD) is associated with poor quality of life. Due to social stigma and its heterogeneous nature, many patients suffer without treatment. Aims This case present…
View article: (030) QUANTITATIVE SENSORY TESTING OF THE CLITORIS, VULVA AND VESTIBULE IN MENOPAUSAL PATIENTS WITH SEXUAL DYSFUNCTION
(030) QUANTITATIVE SENSORY TESTING OF THE CLITORIS, VULVA AND VESTIBULE IN MENOPAUSAL PATIENTS WITH SEXUAL DYSFUNCTION Open
Introduction Individuals in menopause often complain of sexual dysfunction (low libido, reduced sensation, muted orgasm). In sexual-health related menopause concerns, hormonal pathophysiologies have been well studied, however, the effects …
View article: (195) TREATING BREAST CANCER SURVIVORS SEEKING HELP FOR SEXUAL DYSFUNCTION WITH MONITORED HORMONE THERAPY
(195) TREATING BREAST CANCER SURVIVORS SEEKING HELP FOR SEXUAL DYSFUNCTION WITH MONITORED HORMONE THERAPY Open
Introduction Women with breast cancer and symptoms of genitourinary syndrome of menopause (GSM) frequently have sexual dysfunction that can adversely affect quality of life. Both patients and practitioners are apprehensive regarding the us…
View article: (022) “HOW WILL I LOOK AFTER SURGERY?” ASSESSMENT OF VULVOSCOPIC PHOTOGRAPHS AND GENITAL SELF-IMAGE AFTER COMPLETE VESTIBULECTOMY FOR NEUROPROLIFERATIVE VESTIBULODYNIA
(022) “HOW WILL I LOOK AFTER SURGERY?” ASSESSMENT OF VULVOSCOPIC PHOTOGRAPHS AND GENITAL SELF-IMAGE AFTER COMPLETE VESTIBULECTOMY FOR NEUROPROLIFERATIVE VESTIBULODYNIA Open
Introduction The complete vestibulectomy with vaginal advancement flap is an effective treatment for patients with neuroproliferative vestibulodynia (NPV). While pain management is the primary aim of the surgery, patients often express con…
View article: (086) DEVELOPMENT OF A SURVEY TO ASSESS WOMEN’S SEXUAL HEALTH PROVIDERS’ AWARENESS AND APPROACH TOWARD PEYRONIE’S DISEASE AND THE IMPACT ON THE FEMALE SEXUAL PARTNER
(086) DEVELOPMENT OF A SURVEY TO ASSESS WOMEN’S SEXUAL HEALTH PROVIDERS’ AWARENESS AND APPROACH TOWARD PEYRONIE’S DISEASE AND THE IMPACT ON THE FEMALE SEXUAL PARTNER Open
Introduction Peyronie’s disease (PD) is a connective tissue disorder characterized by the development of collagen-containing plaques in the tunica albuginea. This alteration results in penile deformities that are most evident during erecti…
View article: Phase 2 randomized study of abobotulinumtoxinA in patients with provoked vestibulodynia: dose-finding results
Phase 2 randomized study of abobotulinumtoxinA in patients with provoked vestibulodynia: dose-finding results Open
Background Hypertonicity of the pelvic floor muscles is commonly associated with provoked vestibulodynia (PVD); therefore, patients may benefit from treatments that relax the pelvic floor. Aim To define optimal (safe and efficacious) doses…
View article: Randomized trial of low intensity shockwave therapy for erectile dysfunction utilizing grayscale ultrasound for analysis of erectile tissue homogeneity/inhomogeneity
Randomized trial of low intensity shockwave therapy for erectile dysfunction utilizing grayscale ultrasound for analysis of erectile tissue homogeneity/inhomogeneity Open
NCT06600893 on clinicaltrials.gov.
View article: Newer formulations of oral testosterone undecanoate: development and liver side effects
Newer formulations of oral testosterone undecanoate: development and liver side effects Open
Introduction Testosterone deficiency is a clinical disorder due to either failure of the testes to produce testosterone or failure of the hypothalamus or pituitary to produce sufficient gonadotropins. Previous formulations of oral testoste…
View article: Safety, efficacy, and pharmacokinetics of oral testosterone undecanoate in males with hypogonadism
Safety, efficacy, and pharmacokinetics of oral testosterone undecanoate in males with hypogonadism Open
Background Testosterone deficiency results from insufficient testosterone production. Testosterone therapy may require dose titration to reach eugonadal serum testosterone concentrations. Objective The primary objective was the efficacy of…
View article: (276) DISRUPTION OF BIOFILM BY LOW INTENSITY SHOCKWAVE THERAPY TO SUCCESSFULLY TREAT AN INFLATABLE PENILE IMPLANT INFECTION: THREE YEAR FOLLOW-UP
(276) DISRUPTION OF BIOFILM BY LOW INTENSITY SHOCKWAVE THERAPY TO SUCCESSFULLY TREAT AN INFLATABLE PENILE IMPLANT INFECTION: THREE YEAR FOLLOW-UP Open
Introduction Bacterial infection of an inflatable penile implant (IPP) is usually managed by device explantation that is often associated with severe penile fibrosis and decreased length. The decision of device explantation is based on the…
View article: (292) DEVELOPMENT OF A SURVEY TO ASSESS WOMEN’S SEXUAL HEALTH PROVIDERS’ AWARENESS AND APPROACH TOWARD PEYRONIE’S DISEASE AND THE IMPACT ON THE FEMALE SEXUAL PARTNER
(292) DEVELOPMENT OF A SURVEY TO ASSESS WOMEN’S SEXUAL HEALTH PROVIDERS’ AWARENESS AND APPROACH TOWARD PEYRONIE’S DISEASE AND THE IMPACT ON THE FEMALE SEXUAL PARTNER Open
Introduction Peyronie’s disease (PD) is a connective tissue disorder characterized by the development of collagen-containing plaques in the tunica albuginea. This alteration results in penile deformities that are most evident during erecti…
View article: (004) ROUTINE PATHOLOGY EXAMINATION OF EXCISED SPECIMEN FROM PATIENTS WITH NEUROPROLIFERATIVE VESTIBULODYNIA
(004) ROUTINE PATHOLOGY EXAMINATION OF EXCISED SPECIMEN FROM PATIENTS WITH NEUROPROLIFERATIVE VESTIBULODYNIA Open
Introduction Neuroproliferative vestibulodynia (NPV) is suspected in individuals with vulvas with complaints of entrance dyspareunia, vestibular allodynia and hyperalgesia, after ruling out other causes. When conservative biopsychosocial t…
View article: (182) A CHART REVIEW OF LOW-INTENSITY SHOCKWAVE THERAPY WITH UROGOLD 100™ MTS FOR HORMONALLY-MEDIATED VESTIBULODYNIA
(182) A CHART REVIEW OF LOW-INTENSITY SHOCKWAVE THERAPY WITH UROGOLD 100™ MTS FOR HORMONALLY-MEDIATED VESTIBULODYNIA Open
Objectives Low intensity shockwave therapy (LiSWT) is a non-pharmacologic, non-surgical treatment strategy FDA-cleared for pain amelioration. This chart review examines treatment outcome with the Urogold 100™MTS for hormonally-mediated ves…
View article: Immunohistochemical staining with CD117 and PGP9.5 of excised vestibular tissue from patients with neuroproliferative vestibulodynia
Immunohistochemical staining with CD117 and PGP9.5 of excised vestibular tissue from patients with neuroproliferative vestibulodynia Open
Background Neuroproliferative vestibulodynia (NPV), a provoked genital pain characterized by severe allodynia and hyperalgesia, is confirmed in excised vestibular tissue by immunohistochemical staining (>8 CD117-positive immunostained c…
View article: (149) Prevalence of Lumbosacral Annular Tears in Individuals with Hard Flaccid Syndrome
(149) Prevalence of Lumbosacral Annular Tears in Individuals with Hard Flaccid Syndrome Open
Introduction Hard flaccid syndrome (HFS), characterized by the penis in an unwanted persistent semi-rigid flaccid state, is an acquired, painful, and bothersome sexual dysfunction that is poorly understood. We have previously postulated th…
View article: (005) Immunohistochemical Staining of the 12:00 Vestibule in NPV Patients: First Ever Assessment
(005) Immunohistochemical Staining of the 12:00 Vestibule in NPV Patients: First Ever Assessment Open
Introduction In 2004, Bornstein and colleagues performed immunohistochemical (IHC) staining of excised vestibular specimens in patients with vestibular pain. They demonstrated that these specimens contained > 8 CD117 immunopositive stai…
View article: (227) Use of the CNS Agent Bremelanotide in Men with Sexual Dysfunction: Results from a Sexual Medicine Clinic
(227) Use of the CNS Agent Bremelanotide in Men with Sexual Dysfunction: Results from a Sexual Medicine Clinic Open
Introduction Bremelanotide is a centrally acting, cyclic heptapeptide analog of the neuropeptide α-melanocyte-stimulating hormone with elevated affinity for the melanocortin-4 receptor. Bremelanotide modulates dopaminergic pathways involve…
View article: (235) Use of Bremelanotide (Vyleesi) in Men with Sexual Dysfunctions
(235) Use of Bremelanotide (Vyleesi) in Men with Sexual Dysfunctions Open
Introduction Bremelanotide (Vyleesi) is an FDA approved medication for the safe and efficacious treatment of hypoactive sexual desire disorder in premenopausal women, however phase 3 trials revealed it improved arousal and orgasm as well. …
View article: (369) Physician Insights into the Safety of Flibanserin for the Treatment of Sexual Dysfunction in Men
(369) Physician Insights into the Safety of Flibanserin for the Treatment of Sexual Dysfunction in Men Open
Introduction Hypoactive sexual desire disorder (HSDD) is a subtype of persistent low sexual desire (LSD) associated with marked distress with no known cause. LSD/HSDD in men frequently occurs with other sexual dysfunctions. Flibanserin is …
View article: (124) An Open-Label, Vulvoscopic Pilot Study of Intravaginal Prasterone in Menopausal Women with Dyspareunia Examining Vestibular Tissue Changes
(124) An Open-Label, Vulvoscopic Pilot Study of Intravaginal Prasterone in Menopausal Women with Dyspareunia Examining Vestibular Tissue Changes Open
Introduction Prasterone (DHEA), a daily 6.5 mg intravaginal insert, is approved in the US and Canada for moderate to severe dyspareunia, a symptom of vulvovaginal atrophy from menopause. Prasterone converts intracellularly in vaginal epith…
View article: (368) Real World Survey Study to Explore the Effects of Flibanserin in Men with Sexual Dysfunction
(368) Real World Survey Study to Explore the Effects of Flibanserin in Men with Sexual Dysfunction Open
Introduction Low sexual desire (LSD) is a syndrome of symptoms including diminished sexual interest or desire and absence of sexual thoughts or fantasies. Hypoactive sexual desire disorder (HSDD) is a subtype of persistent LSD associated w…
View article: (152) Energy Absorption Simulation During Low Intensity Shockwave Therapy
(152) Energy Absorption Simulation During Low Intensity Shockwave Therapy Open
Introduction Low intensity shockwave therapy (LiSWT) has been used to treat erectile dysfunction since 2010 by inducing mechanotransduction. The greater the shockwave energy absorbed in cavernosal erectile tissue, the greater the opportuni…
View article: (097) Psychosocial Factors in PGAD/GPD Patients Who Underwent Spine Surgery for Lumbosacral Annular Tear-Induced Sacral Radiculopathy
(097) Psychosocial Factors in PGAD/GPD Patients Who Underwent Spine Surgery for Lumbosacral Annular Tear-Induced Sacral Radiculopathy Open
Introduction Persistent genital arousal disorder/genito-pelvic dysesthesia (PGAD/GPD) is characterized by persistent or recurrent, unwanted or intrusive, distressing sensations of genital arousal not associated with concomitant sexual inte…
View article: (148) “Zebras” in Sexual Medicine from Cauda Equina Pathology
(148) “Zebras” in Sexual Medicine from Cauda Equina Pathology Open
Introduction Unrelenting, bothersome sexual medicine problems in individuals with a vulva or penis sometimes do not respond to conventional therapies, frustrating both patient and provider. These distressing problems can be categorized as …
View article: Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health
Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health Open
Background In 1999, 1 year after the approval of the first oral phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED), the first Princeton Consensus Conference was held to address the clinical management …
View article: Health-Care Resource Utilization and Treatment Patterns in Men with Erectile Dysfunction and Benign Prostatic Hyperplasia-Associated Lower Urinary Tract Symptoms in the United States: A Retrospective Database Study
Health-Care Resource Utilization and Treatment Patterns in Men with Erectile Dysfunction and Benign Prostatic Hyperplasia-Associated Lower Urinary Tract Symptoms in the United States: A Retrospective Database Study Open
Patients on tadalafil demonstrated less HCRU and higher persistence and adherence (OD versus as-needed tadalafil) than non-PDE5i patients, which demonstrates its benefit in the management of ED and BPH-LUTS in the US.
View article: (005) The Forgotten Region of the Vestibule: The 12:00 Location
(005) The Forgotten Region of the Vestibule: The 12:00 Location Open
Introduction The vestibule, consisting of the urethral meatus and minor and major vestibular glands, is a unique surface of endodermal tissue between Hart’s line, at the inner aspect of the labia minora, and the hymen, just at the vaginal …