Igor D. Grachev
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View article: Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study
Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study Open
View article: Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices
Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices Open
Previous studies have demonstrated the feasibility and promise of wearable sensors as objective measures of motor impairment in Parkinson disease and essential tremor. However, there are few published studies that have examined such an app…
View article: Characterizing patient compliance over six months in remote digital trials of Parkinson’s and Huntington disease
Characterizing patient compliance over six months in remote digital trials of Parkinson’s and Huntington disease Open
Trials described in this study include a sub-study of the Open PRIDE-HD Huntington's disease study (TV7820-CNS-20016), which was registered on July 7th, 2015, sponsored by Teva Pharmaceuticals Ltd., and registered on Clinicaltrials.gov as …
View article: Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects
Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects Open
Aims SD‐1077, a selectively deuterated precursor of dopamine (DA) structurally related to L‐3,4‐dihydroxyphenylalanine (L‐DOPA), is under development for treatment of motor symptoms of Parkinson's disease. Preclinical models have shown slo…
View article: Alzheimer’s Disease Dementia, Amyloid Imaging and Underpinning Fibrillar Aβ Plaque Associated Pathology: Are They Aligned?
Alzheimer’s Disease Dementia, Amyloid Imaging and Underpinning Fibrillar Aβ Plaque Associated Pathology: Are They Aligned? Open
Aβ and the pathophysiology and neuropathology of Alzheimer's diseaseDefinitive diagnosis of AD relies on the demonstration of amyloid plaques and neurofibrillary tangles at autopsy. 10 Amyloid plaques are composed of the 40-42 amino acid l…