Florin Graur
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View article: Comparative Outcomes of Pancreaticogastrostomy and Pancreaticojejunostomy Following Pancreaticoduodenectomy: A Retrospective Cohort Study from a Romanian High-Volume Center
Comparative Outcomes of Pancreaticogastrostomy and Pancreaticojejunostomy Following Pancreaticoduodenectomy: A Retrospective Cohort Study from a Romanian High-Volume Center Open
Background and Objectives: Pancreaticogastrostomy (PG) and pancreaticojejunostomy (PJ) are the two most frequently employed reconstruction techniques following pancreaticoduodenectomy (PD), yet the optimal method remains debated. The objec…
View article: Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures
Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures Open
Hepatocellular carcinoma (HCC), the most common primary liver malignancy, usually develops in patients with cirrhosis, yet the metabolic mechanisms that distinguish the two conditions remain poorly understood. This study aimed to explore m…
View article: A Systematic Review and Meta-Analysis of Preoperative Biliary Drainage Methods in Periampullary Tumors
A Systematic Review and Meta-Analysis of Preoperative Biliary Drainage Methods in Periampullary Tumors Open
Background: Pancreatic and hepatobiliary tumors continue to rank among the deadliest cancers worldwide. Due to a low response rate to treatment, these tumors continue to have a high death rate, a poor prognosis and survival rate, and an ov…
View article: Biliary Drainage for the Preoperative Management of Periampullary Neoplasms: A Retrospective Cohort Study
Biliary Drainage for the Preoperative Management of Periampullary Neoplasms: A Retrospective Cohort Study Open
Background and Objectives: Preoperative biliary drainage (PBD) in patients with periampullary neoplasms remains a debated topic, with various techniques available and conflicting evidence regarding their impact on postoperative outcomes. T…
View article: Comprehensive Overview of Molecular, Imaging, and Therapeutic Challenges in Rectal Mucinous Adenocarcinoma
Comprehensive Overview of Molecular, Imaging, and Therapeutic Challenges in Rectal Mucinous Adenocarcinoma Open
Rectal cancer is one of the most frequent malignancies worldwide. The most common histological type is adenocarcinoma, followed by mucinous adenocarcinoma. The outcome is less favorable for the mucinous type, yet the treatment course is th…
View article: Changes in Pancreatic Cancer Management and Surgical Treatment During the COVID-19 Pandemic
Changes in Pancreatic Cancer Management and Surgical Treatment During the COVID-19 Pandemic Open
Background and Objectives: This study evaluated the impact of the COVID-19 pandemic on the surgical management of pancreatic ductal adenocarcinoma (PDAC) at a tertiary care hospital in Romania. The objective was to compare surgical volumes…
View article: A 3D-Printed, High-Fidelity Pelvis Training Model: Cookbook Instructions and First Experience
A 3D-Printed, High-Fidelity Pelvis Training Model: Cookbook Instructions and First Experience Open
Background: Since laparoscopic surgery became the gold standard for colorectal procedures, specific skills are required to achieve good outcomes. The best way to acquire basic and advanced skills and reach the learning curve plateau is by …
View article: Liver Phantoms Cast in 3D-Printed Mold for Image-Guided Procedures
Liver Phantoms Cast in 3D-Printed Mold for Image-Guided Procedures Open
Introduction: Image-guided invasive procedures on the liver require a steep learning curve to acquire the necessary skills. The best and safest way to achieve these skills is through hands-on courses that include simulations and phantoms o…
View article: Label-free electrochemical aptasensor for the detection of HepG2 hepatocellular carcinoma cells
Label-free electrochemical aptasensor for the detection of HepG2 hepatocellular carcinoma cells Open
Hepatocellular carcinoma (HCC) is the most common liver malignancy and is characterized by increasing incidence and high mortality rates. Current methods for the screening and diagnosis of HCC exhibit inherent limitations, highlighting the…
View article: Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach
Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach Open
Background: Patients with liver pathology benefit from image-guided interventions. Training for interventional procedures is recommended to be performed on liver phantoms until a basic proficiency is reached. In the last 40 years, several …
View article: HER2 Overexpression in Periampullary Tumors According to Anatomical and Histological Classification—A Systematic Review
HER2 Overexpression in Periampullary Tumors According to Anatomical and Histological Classification—A Systematic Review Open
Pancreatic cancer is one of the most aggressive, heterogeneous, and fatal types of human cancer; therefore, more effective therapeutic drugs are urgently needed. Human epidermal growth factor receptor 2 (HER2) overexpression and amplificat…
View article: Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection
Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection Open
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measuremen…
View article: Impact on Long-term Survival of a Standardized Histopathological Protocol on the R1 Incidence in Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma
Impact on Long-term Survival of a Standardized Histopathological Protocol on the R1 Incidence in Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma Open
Background: Pancreatic Ductal Adenocarcinoma (PDAC) is a pathology with a very poor prognostic, the only curative treatment option being surgery, in association with chemotherapy. This study aims to assess the influence that the use of a s…
View article: Perineal Hernia Mesh Repair Using Only the Perineal Approach: How We Do It
Perineal Hernia Mesh Repair Using Only the Perineal Approach: How We Do It Open
Perineal hernia is a rare complication of rectal surgery. Different types of surgical approach have been described, but none of them have proven their superiority. Although there are many methods of closing the defect, we selected two case…
View article: Robot-Guided Ultrasonography in Surgical Interventions
Robot-Guided Ultrasonography in Surgical Interventions Open
Introduction. The introduction of robotic-guided procedures in surgical techniques has brought an increase in the accuracy and control of resections. Surgery has evolved as a technique since the development of laparoscopy, which has added …
View article: Inflammatory Ratios as Survival Prognostic Factors in Resectable Gastric Adenocarcinoma
Inflammatory Ratios as Survival Prognostic Factors in Resectable Gastric Adenocarcinoma Open
Background: The purpose of the study was to assess the relationship between inflammatory biomarkers (NLR—neutrophil-to-lymphocyte ratio, PLR—platelet-to-lymphocyte ratio, LMR—lymphocyte-to-monocyte ratio, SII—systemic immune-inflammation i…
View article: Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study
Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study Open
Gastric cancer is the fifth type of neoplasia most frequently diagnosed and the fourth cause of death among other cancers. Prevalence is around two times higher for males than females. Chitotriosidase and neopterin are two molecular biomar…
View article: Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study
Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study Open
Gallstones are a common surgical pathology. Laparoscopic cholecystectomy represents the elective treatment. Complicated cases can increase the rate of conversion, the duration, and the difficulty of the intervention, along with the hospita…
View article: Residents Can Do It! A Training Program in Laparoscopic Liver Surgery for General Surgery Residents
Residents Can Do It! A Training Program in Laparoscopic Liver Surgery for General Surgery Residents Open
Introduction: Laparoscopic liver resections (LLRs) constitute an area of surgery that has been kept away from residents in their hands-on training. The aim of our study is to assess the feasibility and the value of a didactic “step-by-step…
View article: Klatskin Tumor: A Survival Analysis According to Tumor Characteristics and Inflammatory Ratios
Klatskin Tumor: A Survival Analysis According to Tumor Characteristics and Inflammatory Ratios Open
Background and Objectives: The aim was to evaluate the association of inflammatory biomarkers with resectability and overall survival in hilar cholangiocarcinoma. Materials and Methods: We conducted a retrospective cohort study over 72 con…
View article: Inflammatory Ratios as Predictors for Tumor Invasiveness, Metastasis, Resectability and Early Postoperative Evolution in Gastric Cancer
Inflammatory Ratios as Predictors for Tumor Invasiveness, Metastasis, Resectability and Early Postoperative Evolution in Gastric Cancer Open
Our study aimed to evaluate the baseline neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in relation to invasion, metastasis, and re…
View article: Trends in Minimally Invasive Approaches for Liver Resections–A Systematic Review
Trends in Minimally Invasive Approaches for Liver Resections–A Systematic Review Open
Background: SILS (single incision laparoscopic surgery) and NOTES (natural orifice transluminal endoscopic surgery) are considered breakthroughs in minimally invasive surgery, the first consisting in the surgeon working via a single entran…
View article: A functional design analysis of a robotic-guided brachytherapy instrument
A functional design analysis of a robotic-guided brachytherapy instrument Open
The paper presents the functional design analysis-based improvements of a robotic guided medical instrument for brachytherapy. The initial design of the medical instrument is analyzed, and its weaknesses are identified and analyzed from se…
View article: Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma
Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma Open
Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. This type of…
View article: The burden on primary caregivers of patients with palliative needs: A multidimensional entity The burden on the primary caregivers
The burden on primary caregivers of patients with palliative needs: A multidimensional entity The burden on the primary caregivers Open
Background The primary caregiver is a person found in the close vicinity of the patient, who is voluntarily and actively involved in the caregiving process. The aim of this study is to measure the burden of the caregivers of palliative car…
View article: Duodenopancreatectomy for PDAC Associated with MALS: A Case Report
Duodenopancreatectomy for PDAC Associated with MALS: A Case Report Open
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of pancreatic malignancy which occurs in over 90% of such cases. Pancreaticoduodenectomy (PD) is used with a curative purpose for localized PDAC. Case presentation…
View article: Colorectal Cancer: Some Variables Commonly Measured in Clinical Practice
Colorectal Cancer: Some Variables Commonly Measured in Clinical Practice Open
Where? Dataset was collected retrospectively from the Third Surgical Clinic, "Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology Cluj-Napoca (https://www.irgh.ro/ro/), Romania. What? Patients with colorectal ca…
View article: Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma: When and how?
Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma: When and how? Open
Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dim prognosis. The role of preoperative and palliative biliary drainage has long been debated. The most common techniques are endoscopic retrograde cholangiopancrea…
View article: Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice? Open
Endorectal ultrasound applications in the evaluation of rectal tumors could be a useful tool in achieving proper staging of rectal cancer. The purpose of this study was to compare the efficacy of rectal tumor staging by flexible endoscopic…