Ian H. de Boer
YOU?
Author Swipe
View article: Association of Sphingolipids with All-Cause and Cardiovascular Death in Patients with Kidney Failure Treated with Maintenance Hemodialysis
Association of Sphingolipids with All-Cause and Cardiovascular Death in Patients with Kidney Failure Treated with Maintenance Hemodialysis Open
Background: Patients with kidney failure on hemodialysis are at a higher risk for death, especially cardiovascular death. Statins (which improve outcomes in general populations) do not improve outcomes in dialysis patients. Sphingolipids a…
View article: Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts
Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts Open
Background Prior prediction equations for heart failure (HF) omitted cardiac biomarkers and used select populations. We assessed the added value of NT‐proBNP (NT‐terminal pro‐brain natriuretic peptide) and hsTnT (high‐sensitivity troponin …
View article: Bone microarchitecture assessed by High-resolution peripheral quantitative computed tomography in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study
Bone microarchitecture assessed by High-resolution peripheral quantitative computed tomography in type 1 diabetes: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study Open
The mechanism for bone fragility in type 1 diabetes (T1D) is unclear. We performed advanced analyses on HR-pQCT images from participants with T1D (n = 183, 59.5 ± 7.0 yr, 50.8% female, T1D duration 38.0 ± 4.8 yr) enrolled in the Epidemiolo…
View article: Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney
Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney Open
Building upon a foundational Human Kidney resource, we present a comprehensive multi-modal atlas that defines spatially resolved versus unresolved repair states and mechanisms in human kidney disease. Homeostatic interactions between injur…
View article: Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules
Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules Open
The organizational principles of nephronal segments are based on anatomical and physiological attributes that are linked to the homeostatic functions of the kidney. Recent molecular approaches have uncovered layers of deeper signatures and…
View article: Relationships among biological sex, body composition, and bone mineral density in young persons with and without diabetes
Relationships among biological sex, body composition, and bone mineral density in young persons with and without diabetes Open
Objectives Bone mineral density (BMD) is influenced by factors including age, sex, body composition, and diabetes. However, data regarding these relationships in young individuals is limited. The objective of this study was to address this…
View article: Patterns in Heart Rate Variability during Hemodialysis
Patterns in Heart Rate Variability during Hemodialysis Open
Key Points Heart rate variability (HRV) metrics did not significantly change over the course of hemodialysis sessions, suggesting poor autonomic function during dialysis. A novel device (Elite HRV CorSense) accurately measured time-domain …
View article: Glycemia Assessed by Continuous Glucose Monitoring among People Treated with Maintenance Dialysis
Glycemia Assessed by Continuous Glucose Monitoring among People Treated with Maintenance Dialysis Open
Key Points In maintenance dialysis, continuous glucose monitoring frequently identified both hyperglycemia and hypoglycemia that may not be clinically evident. Patients with treated diabetes rarely met contemporary continuous glucose monit…
View article: Comparative performance of CKD-EPI equations in people with diabetes: An international pooled analysis of individual participant data
Comparative performance of CKD-EPI equations in people with diabetes: An international pooled analysis of individual participant data Open
The use of CKD-EPI equations has the potential for misdiagnosis and suboptimal CKD management in people with diabetes. Alternative methods of estimating kidney function for people with diabetes are needed to optimally manage diabetes-relat…
View article: Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes
Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes Open
Atherosclerotic CVD is a major cause of death in individuals with type 1 diabetes mellitus (T1DM). However, conventional risk factors do not fully account for the increased risk. This study aimed to investigate whether serum proteins assoc…
View article: The Global Kidney Patient Trials Network and the CAPTIVATE Platform Clinical Trial Design
The Global Kidney Patient Trials Network and the CAPTIVATE Platform Clinical Trial Design Open
Importance Chronic kidney disease (CKD) is a global health priority affecting almost 1 billion people. New therapeutic options and clinical trial innovations such as adaptive platform trials provide an opportunity to efficiently test combi…
View article: Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules
Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules Open
The organizational principles of nephronal segments are based on longstanding anatomical and physiological attributes that are closely linked to the homeostatic functions of the kidney. Novel molecular approaches have recently uncovered la…
View article: Consensus Report on the Use of Continuous Glucose Monitoring in Chronic Kidney Disease and Diabetes
Consensus Report on the Use of Continuous Glucose Monitoring in Chronic Kidney Disease and Diabetes Open
This report represents the conclusions of 15 experts in nephrology and endocrinology, based on their knowledge of key studies and evidence in the field, on the role of continuous glucose monitors (CGMs) in patients with diabetes and chroni…
View article: Attenuated kidney oxidative metabolism in young adults with type 1 diabetes
Attenuated kidney oxidative metabolism in young adults with type 1 diabetes Open
BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30) and healthy contro…
View article: Proteomic Analysis Uncovers Multiprotein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus
Proteomic Analysis Uncovers Multiprotein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus Open
Key Points Proteomics analyses identified seven proteins predictive of time to development of albuminuria among youth with type 2 diabetes in the Treatment Options for Type 2 Diabetes in Adolescents and Youth cohort, 118 proteins predictiv…
View article: Impaired Incretin Homeostasis in Nondiabetic Moderate-to-Severe CKD
Impaired Incretin Homeostasis in Nondiabetic Moderate-to-Severe CKD Open
Key Points Total incretin levels and incretin response during oral glucose tolerance testing were significantly higher among patients with moderate-to-severe nondiabetic patients with CKD compared with healthy people. Unlike in healthy ind…
View article: Improved characterization of gene-environment interactions for vitamin D through variance quantitative trait loci
Improved characterization of gene-environment interactions for vitamin D through variance quantitative trait loci Open
Background Understanding gene-environment interaction effects influencing vitamin D status may refine nutrition and public health strategies for vitamin D deficiency. Recent methodological advances have enabled the identification of varian…
View article: Randomized Crossover Clinical Trial of Nicotinamide Riboside and Coenzyme Q10 on Metabolic Health and Mitochondrial Bioenergetics in CKD
Randomized Crossover Clinical Trial of Nicotinamide Riboside and Coenzyme Q10 on Metabolic Health and Mitochondrial Bioenergetics in CKD Open
Background Mitochondria-driven oxidative/redox stress and inflammation play a major role in chronic kidney disease (CKD) pathophysiology. Compounds targeting mitochondrial metabolism may improve mitochondrial function, inflammation, and re…
View article: Single-Ancestry versus Multi-Ancestry Polygenic Risk Scores for CKD in Black American Populations
Single-Ancestry versus Multi-Ancestry Polygenic Risk Scores for CKD in Black American Populations Open
Key Points The predictive performance of an African ancestry–specific polygenic risk score (PRS) was comparable to a European ancestry–derived PRS for kidney traits. However, multi-ancestry PRSs outperform single-ancestry PRSs in Black Ame…
View article: Glycolytic lactate in diabetic kidney disease
Glycolytic lactate in diabetic kidney disease Open
Lactate elevation is a well-characterized biomarker of mitochondrial dysfunction, but its role in diabetic kidney disease (DKD) is not well defined. Urine lactate was measured in patients with type 2 diabetes (T2D) in 3 cohorts (HUNT3, SMA…
View article: WCN24-606 PROTEOMIC ANALYSIS UNCOVERS NEW CIRCULATING PROTEINS ASSOCIATED WITH INCIDENT HYPERTENSION OVER 15 YEARS IN YOUTH WITH TYPE 2 DIABETES
WCN24-606 PROTEOMIC ANALYSIS UNCOVERS NEW CIRCULATING PROTEINS ASSOCIATED WITH INCIDENT HYPERTENSION OVER 15 YEARS IN YOUTH WITH TYPE 2 DIABETES Open
Hypertension is common in youth with type 2 diabetes (T2D), increasing risk of cardiovascular disease. The mechanisms underlying the high burden of hypertension in youth with T2D remains incompletely understood.
View article: <b>Associations of kidney tubular biomarkers with incident macroalbuminuria and sustained low eGFR in DCCT/EDIC</b>
<b>Associations of kidney tubular biomarkers with incident macroalbuminuria and sustained low eGFR in DCCT/EDIC</b> Open
Objective: Tubulointerstitial injury contributes to diabetic kidney disease (DKD) progression. We tested tubular biomarker associations with DKD development in type 1 diabetes (T1D). Research Design and Methods: A case-cohort study examine…
View article: <b>Associations of kidney tubular biomarkers with incident macroalbuminuria and sustained low eGFR in DCCT/EDIC</b>
<b>Associations of kidney tubular biomarkers with incident macroalbuminuria and sustained low eGFR in DCCT/EDIC</b> Open
Objective: Tubulointerstitial injury contributes to diabetic kidney disease (DKD) progression. We tested tubular biomarker associations with DKD development in type 1 diabetes (T1D). Research Design and Methods: A case-cohort study examine…