Songi Han
YOU?
Author Swipe
View article: Correction to “Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations”
Correction to “Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations” Open
[This corrects the article DOI: 10.1021/jacsau.3c00550.].
View article: Coherent Control over Nuclear Hyperpolarization Using an Optically Initializable Chromophore-Radical System
Coherent Control over Nuclear Hyperpolarization Using an Optically Initializable Chromophore-Radical System Open
Chromophore radicals (CR) are emerging as important components for molecular quantum information science (QIS), especially in the context of quantum sensing. Here, we demonstrate that the optically hyperpolarized electrons in a 1,6,7,12-te…
View article: Solution‐Like Water Transport Across Molecular to Macroscopic Length Scales in Crosslinked Poly(Ethylene Glycol Diacrylate) Networks With Tailored Sidechains
Solution‐Like Water Transport Across Molecular to Macroscopic Length Scales in Crosslinked Poly(Ethylene Glycol Diacrylate) Networks With Tailored Sidechains Open
Poly(ethylene glycol) (PEG)‐based materials, like PEG‐diacrylate (PEGDA), are prized for their hydrophilic, inert properties, and leveraged in hydrogels and as membrane mimics. While network chemistry is often tuned for selective transport…
View article: Structure-specific Mini-Prion Model for Alzheimer’s Disease Tau Fibrils
Structure-specific Mini-Prion Model for Alzheimer’s Disease Tau Fibrils Open
A critical discovery of the past decade is that tau protein fibrils adopt disease-specific hallmark structures in each tauopathy. The faithful generation of synthetic fibrils adopting hallmark structures that can serve as targets for devel…
View article: Hydraulic Activation of the AsLOV2 Photoreceptor
Hydraulic Activation of the AsLOV2 Photoreceptor Open
How proteins transduce light into mechanical energy remains a central question in biology. This study tests the hypothesis that blue light activation of the LOV2 (light, oxygen, voltage sensitive) domain of Avena sativa phototropin 1 (AsLO…
View article: Water-directed pinning is key to tau prion formation
Water-directed pinning is key to tau prion formation Open
Tau forms fibrillar aggregates that are pathological hallmarks of a family of neurodegenerative diseases known as tauopathies. The synthetic replication of disease-specific fibril structures is a critical gap for developing diagnostic and …
View article: Hydrolytically Stable Phosphonate‐Based Metal–Organic Frameworks for Harvesting Water from Low Humidity Air
Hydrolytically Stable Phosphonate‐Based Metal–Organic Frameworks for Harvesting Water from Low Humidity Air Open
Harvesting water from air offers a promising solution to the global water crisis. However, existing sorbents often struggle in arid climates due to limitations such as low sorption capacities, hydrolytic instability, slow mass transport, h…
View article: P1 center network in high-pressure high-temperature diamonds is a readily accessible source of nuclear hyperpolarization at 14 T
P1 center network in high-pressure high-temperature diamonds is a readily accessible source of nuclear hyperpolarization at 14 T Open
We investigate nitrogen substitution defects, also known as P1 centers, in type 1b diamonds as a source of electron spin polarization that is readily transferred to 13C nuclear spins within the diamond matrix at 14 Tesla by dynamic nuclear…
View article: Localized Reconstruction of Multimodal Distance Distribution from DEER Data of Biopolymers
Localized Reconstruction of Multimodal Distance Distribution from DEER Data of Biopolymers Open
Pulsed Dipolar ESR Spectroscopy (PDS) is a uniquely powerful technique to characterize the structural property of intrinsically disordered proteins (IDPs) and polymers and the conformational evolution of IDPs and polymers, e.g. during asse…
View article: Phosphoryl group wires stabilize pathological tau fibrils as revealed by multiple quantum spin counting NMR
Phosphoryl group wires stabilize pathological tau fibrils as revealed by multiple quantum spin counting NMR Open
Hyperphosphorylation of the protein tau is one of the biomarkers of neurodegenerative diseases in the category of tauopathies. However, the molecular level, mechanistic, role of this common post- translational modification (PTM) in enhanci…
View article: Field-domain rapid-scan EPR at 240 GHz for studies of protein functional dynamics at room temperature
Field-domain rapid-scan EPR at 240 GHz for studies of protein functional dynamics at room temperature Open
We present field-domain rapid-scan (RS) electron paramagnetic resonance (EPR) at 8.6T and 240GHz. To enable this technique, we upgraded a home-built EPR spectrometer with an FPGA-enabled digitizer and real-time processing software. The sof…
View article: Dynamic Nuclear Polarization Enhanced Multiple-Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions
Dynamic Nuclear Polarization Enhanced Multiple-Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions Open
Crystallization pathways are essential to various industrial, geological, and biological processes. In nonclassical nucleation theory, prenucleation clusters (PNCs) form, aggregate, and crystallize to produce higher order assemblies. Micro…
View article: Dynamic Nuclear Polarization Enhanced Multiple Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions
Dynamic Nuclear Polarization Enhanced Multiple Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions Open
Crystallization pathways are essential to various industrial, geological, and biolog- ical processes. In nonclassical nucleation theory, prenucleation clusters (PNCs) form, aggregate and crystallize to produce higher order assemblies. Micr…
View article: Dynamic Nuclear Polarization Enhanced Multiple Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions
Dynamic Nuclear Polarization Enhanced Multiple Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions Open
Crystallization pathways are essential to various industrial, geological, and biolog- ical processes. In nonclassical nucleation theory, prenucleation clusters (PNCs) form, aggregate and crystallize to produce higher order assemblies. Micr…
View article: Dipolar Order Induced Electron Spin Hyperpolarization
Dipolar Order Induced Electron Spin Hyperpolarization Open
The structure of coupled electron spin systems is of fundamental interest to many applications, including dynamic nuclear polarization (DNP), enhanced nuclear magnetic resonance (NMR), the generation of electron spin qubits for quantum inf…
View article: Precision proteoform design for 4R tau isoform selective templated aggregation
Precision proteoform design for 4R tau isoform selective templated aggregation Open
Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. A 19-residue probe peptide containing a P301L mutation and spanning the R2/R3 splice junction of tau folds and stacks into seeding-competent fibrils and…
View article: Control over Conformational Landscapes of Polypeptoids by Monomer Sequence Patterning
Control over Conformational Landscapes of Polypeptoids by Monomer Sequence Patterning Open
The ability to program chain conformation and structure through control over the monomer sequence of synthetic polymers has broad implications for next-generation material design. While related problems of protein-folding and de novo desig…
View article: Insights into conformational ensembles of compositionally identical disordered peptidomimetics
Insights into conformational ensembles of compositionally identical disordered peptidomimetics Open
A model system of peptidomimetics was developed to characterize the complex conformational ensembles of compositionally identical disordered peptoids using a suite of analyses, including a rapid colorimetric technique.
View article: Nanoscale water–polymer interactions tune macroscopic diffusivity of water in aqueous poly(ethylene oxide) solutions
Nanoscale water–polymer interactions tune macroscopic diffusivity of water in aqueous poly(ethylene oxide) solutions Open
PEO restructures water near the polymer, reducing free volume and slowing local water.
View article: Computation of Overhauser dynamic nuclear polarization processes reveals fundamental correlation between water dynamics, structure, and solvent restructuring entropy
Computation of Overhauser dynamic nuclear polarization processes reveals fundamental correlation between water dynamics, structure, and solvent restructuring entropy Open
Hydration water dynamics, structure, and thermodynamics are crucially important to understand and predict water-mediated properties at molecular interfaces.
View article: Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations
Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations Open
Amyloid aggregation of the intrinsically disordered protein (IDP) tau is involved in several diseases, called tauopathies. Some tauopathies can be inherited due to mutations in the gene encoding tau, which might favor the formation of tau …
View article: Multi Electron Spin Cluster Enabled Dynamic Nuclear Polarization with Sulfonated BDPA
Multi Electron Spin Cluster Enabled Dynamic Nuclear Polarization with Sulfonated BDPA Open
Dynamic nuclear polarization (DNP) can amplify the solid-state nuclear magnetic resonance (NMR) signal by several orders of magnitude. The mechanism of DNP utilizing α,γ-bisdiphenylene-β-phenylallyl (BDPA) variants as Polarizing Agents (PA…
View article: The Dynamic Catalytic Activity of Phosphorus-containing Catalysts
The Dynamic Catalytic Activity of Phosphorus-containing Catalysts Open
The active site speciation of phosphorus-containing all-silica zeolites, P-zeosils, involves a dynamic distribution that is manipulated through controlled hydrolysis of the catalytic material. While water vapor is known to enhance the cata…
View article: Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement
Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement Open
Tau forms toxic fibrillar aggregates in a family of neurodegenerative diseases known as tauopathies. The faithful replication of tauopathy-specific fibril structures is a critical gap for developing diagnostic and therapeutic tools. This s…
View article: The Dynamic Catalytic Activity of Phosphorus-containing Catalysts
The Dynamic Catalytic Activity of Phosphorus-containing Catalysts Open
The active site speciation of phosphorus-containing all-silica zeolites, P-zeosils, involves a dynamic distribution that is manipulated through controlled hydrolysis of the catalytic material. While water vapor is known to enhance the cata…
View article: Gadolinium Spin Decoherence Mechanisms at High Magnetic Fields
Gadolinium Spin Decoherence Mechanisms at High Magnetic Fields Open
Favorable relaxation processes, high-field spectral properties, and biological compatibility have made spin-7/2 Gd3+-based spin labels an increasingly popular choice for protein structure studies using high-field electron paramagnetic reso…
View article: P1 center electron spin clusters are prevalent in type Ib diamond
P1 center electron spin clusters are prevalent in type Ib diamond Open
Understanding the spatial distribution of P1 centers is crucial for diamond-based sensors and quantum devices. P1 centers serve as a polarization source for DNP quantum sensing and play a significant role in the relaxation of NV centers. A…
View article: Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation
Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation Open
Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. A 19-residue probe peptide containing a P301L mutation and spanning the R2/R3 splice junction of tau, folds and stacks into seeding-competent fibrils an…
View article: Effects of Abalone Shell Extract on Proliferation of Retinal Pigment Epithelial Cells Induced by TGF-β1
Effects of Abalone Shell Extract on Proliferation of Retinal Pigment Epithelial Cells Induced by TGF-β1 Open
본 연구는 석결명을 초산화 하여 추출물을 획득하고, 초산화한 석결명 추출물이 TGF-β1로 유도된 망막색소상피세포에서의 전이에 미치는 영향과 그 기본 메커니즘을 조사하고자 하였다. 먼저 석결명 가루를 초산화 과정을 거쳐 추출한 후 초산화한 석결명 추출물의 세포 독성을 확인하고자 WST-1 assay법을 이용하여 측정하였고, TGF-β1과 초산화한 석결명 추출물을 동시에 망막색소상피세포에 처리한 후 morphology의 변화를…