Yen‐Ju Chen
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View article: Observation and Manipulation of Optical Parametric Downconversion in the Langevin Regime
Observation and Manipulation of Optical Parametric Downconversion in the Langevin Regime Open
Quantum fluctuation plays a key role in parametric down-conversion in the Langevin regime. In this Letter, we report the experimental realization of optical parametric down-conversion in the Langevin regime on a chip. By precisely controll…
View article: The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies
The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies Open
Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies 1,2 , so there is an urgent need for large-scale cohorts to advance precision medicine. Here we present the Taiwan Precision Me…
View article: Periodicity and Dynamical Systems of Dickson Polynomials in Finite Fields
Periodicity and Dynamical Systems of Dickson Polynomials in Finite Fields Open
This paper investigates the dynamical properties of Dickson polynomials over finite fields, focusing on the periodicity and structural behavior of their iterated sequences. We introduce and analyze the sequence $[D_n(x, α) \mod (x^q - x)]_…
View article: Clinical impact of pharmacogenetic risk variants in a large chinese cohort
Clinical impact of pharmacogenetic risk variants in a large chinese cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. A key advantage of PGx-guided therapy is to decrease t…
View article: Endophthalmitis after intravitreal injection with or without triamcinolone – A 10-year investigation in a tertiary hospital
Endophthalmitis after intravitreal injection with or without triamcinolone – A 10-year investigation in a tertiary hospital Open
PURPOSE: Intravitreal injections (IVIs) have been the most important treatment strategies in retinal diseases. With the increasing use of IVIs, the incidence of endophthalmitis has inevitably risen. Triamcinolone acetonide (TA) used in IVI…
View article: Clinical Efficacy and Safety of Reduced-Dose Prasugrel After Percutaneous Coronary Intervention for Taiwanese Patients with Acute Coronary Syndromes
Clinical Efficacy and Safety of Reduced-Dose Prasugrel After Percutaneous Coronary Intervention for Taiwanese Patients with Acute Coronary Syndromes Open
Background/Objectives: The efficacy and safety of reduced-dose prasugrel (loading dose/maintenance dose: 20/3.75 mg) in preventing major adverse cardiovascular events (MACEs) among patients with acute coronary syndrome (ACS) undergoing per…
View article: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response1. One of the most pro…
View article: The Taiwan Precision Medicine Initiative: A Cohort for Large-Scale Studies
The Taiwan Precision Medicine Initiative: A Cohort for Large-Scale Studies Open
The Taiwan Precision Medicine Initiative (TPMI), a project initiated by the Academia Sinica in collaboration with 16 major medical centers around Taiwan, has recruited 565,390 participants who consented to provide DNA samples for genetic p…
View article: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response 1 . One of the most promising be…
View article: An innovative Hearing AED alarm system shortens delivery time of automated external defibrillator – A randomized controlled simulation study
An innovative Hearing AED alarm system shortens delivery time of automated external defibrillator – A randomized controlled simulation study Open
View article: Associations between body weight trajectories and neurodevelopment outcomes at 24 months corrected age in very-low-birth-weight preterm infants: a group-based trajectory modelling study
Associations between body weight trajectories and neurodevelopment outcomes at 24 months corrected age in very-low-birth-weight preterm infants: a group-based trajectory modelling study Open
Introduction This study aimed to explore the relationship between the trajectories of body weight (BW) z -scores at birth, discharge, and 6 months corrected age (CA) and neurodevelopmental outcomes at 24 months CA. Methods Conducted as a p…
View article: RETRACTED: Cheng et al. Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test. Genes 2021, 12, 1539
RETRACTED: Cheng et al. Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test. Genes 2021, 12, 1539 Open
The Genes journal retracts the article “Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test” [...]
View article: Predicting early mortality and severe intraventricular hemorrhage in very-low birth weight preterm infants: a nationwide, multicenter study using machine learning
Predicting early mortality and severe intraventricular hemorrhage in very-low birth weight preterm infants: a nationwide, multicenter study using machine learning Open
Our aim was to develop a machine learning-based predictor for early mortality and severe intraventricular hemorrhage (IVH) in very-low birth weight (VLBW) preterm infants in Taiwan. We collected retrospective data from VLBW infants, dividi…
View article: Interleukin‐4 inhibits the hypothalamic appetite control by modulating the insulin<scp>‐AKT</scp> and <scp>JAK‐STAT</scp> signaling in leptin mutant mice
Interleukin‐4 inhibits the hypothalamic appetite control by modulating the insulin<span>‐AKT</span> and <span>JAK‐STAT</span> signaling in leptin mutant mice Open
Our previous research identified interleukin‐4 (IL‐4) as a key regulator of glucose/lipid metabolism, circulatory leptin levels, and insulin action, suggesting its potential as a therapeutic target for obesity and related complications. Th…
View article: Prevention of Viral Hepatitis and HIV Infection among People Who Inject Drugs: A Systematic Review and Meta-Analysis
Prevention of Viral Hepatitis and HIV Infection among People Who Inject Drugs: A Systematic Review and Meta-Analysis Open
This study aimed to explore the current evidence on preventing blood-borne virus infections among people who inject drugs (PWID). We conducted a comprehensive search across three databases (PubMed, Embase, Cochrane Library) for relevant ar…
View article: PIP2 regulating calcium signal modulates actin cytoskeleton-dependent cytoadherence and cytolytic capacity in the protozoan parasite Trichomonas vaginalis
PIP2 regulating calcium signal modulates actin cytoskeleton-dependent cytoadherence and cytolytic capacity in the protozoan parasite Trichomonas vaginalis Open
Trichomonas vaginalis is a prevalent causative agent that causes trichomoniasis leading to uropathogenic inflammation in the host. The crucial role of the actin cytoskeleton in T . vaginalis cytoadherence has been established but the assoc…
View article: Effects of Bad News on Stock Returns and Analysts’ Recommendations: The Influence of Executive Gender
Effects of Bad News on Stock Returns and Analysts’ Recommendations: The Influence of Executive Gender Open
Although women are more conservative and more ethical than men, the proportion of female executives is still lower than that of men. Both Chief Executive Officers (CEOs) and Chief Financial Officers (CFOs) have strong influences in making …
View article: Transcriptome and Mutant Analysis of Neuronal Genes for Memory Formation and Retrieval in<i>Caenorhabditis elegans</i>
Transcriptome and Mutant Analysis of Neuronal Genes for Memory Formation and Retrieval in<i>Caenorhabditis elegans</i> Open
Summary Although it is generally believed that the formation and retrieval of memory require distinct sets of genes, little is known about the identity and temporal specificity of genes that act at different memory stages. Here we characte…
View article: The composition of the maternal breastmilk microbiota influences the microbiota network structure during early infancy
The composition of the maternal breastmilk microbiota influences the microbiota network structure during early infancy Open
Our work suggests that maternal metabolic status plays a crucial role in Staphylococcus/Streptococcus competition in BM, which in turn can impact the development of the infant microbiota. Our microbiota co-occurrence network analysis might…
View article: A Comprehensive Phylogenetic Analysis of SARS-CoV-2: Utilizing a Novel and Convenient In-House RT-PCR Method for Characterization without Virus Culture and BSL-3 Facilities
A Comprehensive Phylogenetic Analysis of SARS-CoV-2: Utilizing a Novel and Convenient In-House RT-PCR Method for Characterization without Virus Culture and BSL-3 Facilities Open
We developed a convenient method for amplifying the complete SARS-CoV-2 sequence using in-house RT-PCR without virus culture. Forty-one stored throat swabs and blood specimens were collected from eight SARS-CoV-2 infections at multiple tim…
View article: Supplementary Figure S8 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S8 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S8 shows the validation of gene regulation by NCGC00117362 in ovarian cancer cell lines and effect of PP-121 and Milciclib on these genes.
View article: Supplementary Figure S3 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S3 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S3 shows the activity of non-lead compounds in secondary confirmatory assays.
View article: Supplementary Figure S3 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S3 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S3 shows the activity of non-lead compounds in secondary confirmatory assays.
View article: Supplementary Figure S7 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S7 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S7 shows the effect of Milciclib and NCGC00117362 on mTOR, and PP-121 and NCGC00117362 on retinoblastoma.
View article: Supplementary Figure S5 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S5 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S5 shows the activity of inert compounds and mTOR inhibitors in secondary biological in vivo adhesion/invasion assay.
View article: Supplemental Figure S2 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplemental Figure S2 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S2 shows the activity outcomes from confirmatory and counter screens.
View article: Data from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Data from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
The tumor microenvironment (TME) is a key determinant of metastatic efficiency. We performed a quantitative high-throughput screen (qHTS) of diverse medicinal chemistry tractable scaffolds (44,420 compounds) and pharmacologically active sm…
View article: Supplementary Figure S4 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S4 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S4 shows the activity of non-lead compounds in secondary biological assays.
View article: Supplementary Figure S9 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplementary Figure S9 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S9 shows the testing of SAR analogs of NCGC00117362 in secondary confirmatory assays.
View article: Supplemental Figure S2 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis
Supplemental Figure S2 from Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis Open
Supplementary Figure S2 shows the activity outcomes from confirmatory and counter screens.