I. М. Kvetnoy
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View article: Signaling Molecules and Diagnosis of Cognitive Disorders: Current State and Prospects
Signaling Molecules and Diagnosis of Cognitive Disorders: Current State and Prospects Open
Cognitive disorders present significant medical and social challenges nowadays, due to their high prevalence, progressive course and a lack of effective methods for treatment of neurodegenerative diseases and comorbid pathologies. An impor…
View article: SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study
SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study Open
Sirtuins (SIRT1–SIRT7) are NAD+-dependent deacetylases that link cellular energy status to chromatin maintenance, mitochondrial function and inflammatory signaling. While modulation of SIRT1, SIRT3 and SIRT6 extends lifespan in model organ…
View article: Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases
Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases Open
Research in the field of mitochondrial biomarkers plays an important role in understanding the processes of cellular aging. Mitochondria are not only the energy centers of the cell, but also key regulators of signaling within the cell. The…
View article: Alzheimer’s Disease: Non-Invasive Method and an Immunocytochemical Panel of Molecular Markers for Screening and Life-Time Diagnosis
Alzheimer’s Disease: Non-Invasive Method and an Immunocytochemical Panel of Molecular Markers for Screening and Life-Time Diagnosis Open
Alzheimer's disease (AD) remains one of the most significant medical and social problems nowadays, which is due to its high prevalence, progressive course and a lack of effective treatment methods. The most important path for solving this …
View article: SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study
SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study Open
Sirtuins (SIRT1–SIRT7) are NAD⁺ dependent deacylases that link cellular energy status to chromatin maintenance, mitochondrial function and in-flammatory signaling. While modulation of SIRT1, SIRT3 and SIRT6 extends lifespan in model organi…
View article: Influence of Injectable Hyaluronic Gel System on Skin Microbiota, Skin Defense Mechanisms and Integrity (Ex vivo Study)
Influence of Injectable Hyaluronic Gel System on Skin Microbiota, Skin Defense Mechanisms and Integrity (Ex vivo Study) Open
Our investigation showed that both intradermal injections, HA-based solution or control excipient, trigger short-term skin microbiota growth. We indicate strong influence of non-sterile skin surface conditions on human skin explant viabili…
View article: Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications
Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications Open
This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogen…
View article: Lung cancer and pulmonary tuberculosis: key features of molecular mechanisms of concomitant disease
Lung cancer and pulmonary tuberculosis: key features of molecular mechanisms of concomitant disease Open
Lung cancer and pulmonary tuberculosis have long been significant problems for global health, occupying leading positions in terms of morbidity and mortality in both developed and developing countries. Numerous clinical and experimental st…
View article: Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications
Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications Open
This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogen…
View article: Transcription Factor NF-κB: Role and Significance in the Neuroimmunoendocrine Regulation of Respiratory Function in Normal Conditions and in Lung Pathology
Transcription Factor NF-κB: Role and Significance in the Neuroimmunoendocrine Regulation of Respiratory Function in Normal Conditions and in Lung Pathology Open
The problem of modern biomedicine is the elucidation of the multicomponent and multilevel mechanism of a single neuroimmunoendocrine regulation of physiological functions, which plays the role of a universal conductor of all life processes…
View article: Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility
Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility Open
Cellular aging is considered as one of the main factors implicated in female infertility. We evaluated the expression of senescence-associated secretory phenotype (SASP) markers and additional molecular factors in an in vitro model of cell…
View article: Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype
Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype Open
Cellular aging is considered as one of the main factors leading to female infertility. The process called “inflammaging”, which was proposed by C. Franceschi in 2014 is characterized by chronic asymptomatic inflammation state resulting to …
View article: Effect of a hyaluronic acid‐based mesotherapeutic injectable on the gene expression of <i><scp>CLOCK</scp> and Klotho</i> proteins, and environmentally induced oxidative stress in human skin cells
Effect of a hyaluronic acid‐based mesotherapeutic injectable on the gene expression of <i><span>CLOCK</span> and Klotho</i> proteins, and environmentally induced oxidative stress in human skin cells Open
Objective Normal circadian rhythms are essential to the repair mechanisms of oxidative stress implicated in skin aging. Given reports that hyaluronic acid (HA) homeostasis exhibits a different profile in chronological skin aging, as compar…
View article: Mitochondrial Proteins as Molecular Targets For Glutathione-Based Drugs
Mitochondrial Proteins as Molecular Targets For Glutathione-Based Drugs Open
Mitochondrion is one of the most important cell organelles which provide cells with energy, participate in cell turnover and activate endogenous mechanisms of cell-mediated immunity. Research into the structural and functional organization…
View article: Melatonin as the Cornerstone of Neuroimmunoendocrinology
Melatonin as the Cornerstone of Neuroimmunoendocrinology Open
Much attention has been recently drawn to studying melatonin – a hormone whose synthesis was first found in the epiphysis (pineal gland). This interest can be due to discovering the role of melatonin in numerous physiological processes. It…
View article: Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology
Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology Open
This investigation showed that the studied fillers have biological effects, testifying the stimulation of reparative processes in the skin under their control.
View article: Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets
Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets Open
Sudden infant death syndrome (SIDS) is one of the primary causes of death of infants in the first year of life. According to the WHO’s data, the global infant mortality rate is 0.64–2 per 1,000 live-born children. Molecular and cellular as…
View article: Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression
Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression Open
Embryogenesis is a complex multi-stage process regulated by various signaling molecules including pineal and extrapineal melatonin (MT). Extrapineal MT is found in the placenta and ovaries, where it carries out local hormonal regulation. M…
View article: Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis
Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis Open
The review summarizes the results of experimental and clinical studies aimed at elucidating the causes and pathophysiological mechanisms of the development of endocrine pathology in children. The modern data on the role of epigenetic influ…
View article: Clinical and laboratory markers for different variants of the course of irritable bowel syndrome
Clinical and laboratory markers for different variants of the course of irritable bowel syndrome Open
Internal diseasesДЭС -диффузная эндокринная система ЖКТ -желудочно-кишечный тракт РГА -Российская гастроэнтерологическая ассоциация СОТК -слизистая оболочка толстой кишки СРК -синдром раздраженного кишечника СРК-д -синдром раздраженного ки…
View article: Chronic periodontitis and ischemic heart disease: morphofunctional relation-ships
Chronic periodontitis and ischemic heart disease: morphofunctional relation-ships Open
The relationship between periodontal diseases and cardiovascular pathology is actively being studied. The clinical significance of tissue markers of endothelial dysfunction in acute or chronic periodontitis needs to be clarified.
Material…
View article: Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies Open
Melatonin (MT) and sirtuins (SIRT) are geroprotective molecules that hold back the aging process and the development of age-related diseases, including cardiovascular pathologies. Buccal epithelium (BE) sampling is a non-invasive procedure…
View article: Detection of Apoptosis in Cancer Cells Using Heat Shock Protein 70 and p53 Antibody Conjugated Quantum Dot Nanoparticles
Detection of Apoptosis in Cancer Cells Using Heat Shock Protein 70 and p53 Antibody Conjugated Quantum Dot Nanoparticles Open
Clinical experience indicates that enhanced level of heat shock protein 70 (Hsp70) and p53 correlates with poor prognosis due to malignant cell overexpression of these proteins in tumor progression. Cadmium selenide quantum dots (QDs) were…
View article: Current trends in the treatment of chronic placental insufficiency
Current trends in the treatment of chronic placental insufficiency Open
According to literature, intrauterine growth retardation complicates about 5% of pregnancies and is usually caused by chronic placental insufficiency. This article reviews literature data on modern views on the issue. Special attention is …
View article: The Role of Prenatal Melatonin in the Regulation of Childhood Obesity
The Role of Prenatal Melatonin in the Regulation of Childhood Obesity Open
There is a growing awareness that pregnancy can set the foundations for an array of diverse medical conditions in the offspring, including obesity. A wide assortment of factors, including genetic, epigenetic, lifestyle, and diet can influe…
View article: Features of the placenta structure in post-term pregnancy
Features of the placenta structure in post-term pregnancy Open
This review deals with the formation and structure of the placenta in the full-term gestational period and during post-term gestation. The results of various morphological and immunohistochemical studies are analyzed, highlighting changes …
View article: Signal molecules involved in the formation of new nerve endings in endometriosis (review)
Signal molecules involved in the formation of new nerve endings in endometriosis (review) Open
Кветной 1,4 Сигнальные молекулы, вовлеченные в образование новых нервных окончаний при эндометриозе (обзор) 1 Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт акушерства