Lars Larsson
YOU?
Author Swipe
An Investigation of Extended Range Singing Prompts for the Singing Voice Development Measure Open
The Singing Voice Development Measure (SVDM) was created to provide some consistency with what children are asked to sing, how their singing is prompted, and how their singing is evaluated, particularly in research studies. Although the SV…
Effects of inhibition of Janus kinase signalling during controlled mechanical ventilation on the rate of skeletal muscle protein synthesis Open
We employed a unique murine intensive care unit (ICU) model allowing long‐term studies of the ICU condition (immobilization, paralysis, sedation and mechanical ventilation). This model resulted in a substantial loss of myofibrillar protein…
View article: Padua Days on Muscle and Mobility Medicine, March 25-29, 2025, Hotel Petrarca, Euganean Thermae, Italy: Program and Abstracts
Padua Days on Muscle and Mobility Medicine, March 25-29, 2025, Hotel Petrarca, Euganean Thermae, Italy: Program and Abstracts Open
Medium-sized scientific conferences held in hotels large enough to accommodate all participants increase opportunities for constructive discussion during breaks, and for evenings that bring together young and senior experts of basic scienc…
Elk antler mattock-heads from southern and northern Sweden, and the importance of elk in social contexts Open
The ecological conditions show synchronous differences between southern and northern Sweden, due to the delayed immigration of flora and fauna in such a long, narrow country. One of the first forest animals to immigrate was the elk. It was…
View article: Ruxolitinib: A new hope for ventilator‐induced diaphragm dysfunction
Ruxolitinib: A new hope for ventilator‐induced diaphragm dysfunction Open
Aim Mechanical ventilation (MV) results in diminished diaphragm size and strength, termed ventilator‐induced diaphragm dysfunction (VIDD). VID increases dependence, prolongs weaning, and increases discharge mortality rates. The Janus kinas…
Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report Open
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairme…
Publisher Correction: Population genomics of post-glacial western Eurasia Open
Correction to: Nature Published online 10 January 2024 In the version of this article initially published, there were errors in the second affiliations for Levon Yepiskoposyan (Russian-Armenian University, Yerevan, Armenia) and Sergey Vasi…
View article: Population genomics of post-glacial western Eurasia
Population genomics of post-glacial western Eurasia Open
Western Eurasia witnessed several large-scale human migrations during the Holocene 1–5 . Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic peri…
View article: Management of complications after skin surgery relevant for melanoma in the trunk and extremities during the COVID-19 pandemic: a case series report
Management of complications after skin surgery relevant for melanoma in the trunk and extremities during the COVID-19 pandemic: a case series report Open
Background Patients with melanoma have been found to be at greater risk of adverse outcomes including mortality after contacting COVID-19. Management of postsurgical complications presented additional challenges by potentially increasing e…
View article: Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment
Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment Open
Ventilator-induced diaphragm dysfunction (VIDD) is a common sequela of intensive care unit (ICU) treatment requiring mechanical ventilation (MV) and neuromuscular blockade (NMBA). It is characterised by diaphragm weakness, prolonged respir…
Direct electrical stimulation impacts on neuromuscular junction morphology on both stimulated and unstimulated contralateral soleus Open
Background There is increasing evidence of crosstalk between organs. The neuromuscular junction (NMJ) is a peripheral chemical synapse whose function and morphology are sensitive to acetylcholine (ACh) release and muscle depolarization. In…
View article: A prospective clinical study on the mechanisms underlying critical illness myopathy—A time‐course approach
A prospective clinical study on the mechanisms underlying critical illness myopathy—A time‐course approach Open
Background Critical illness myopathy (CIM) is a consequence of modern critical care resulting in general muscle wasting and paralyses of all limb and trunk muscles, resulting in prolonged weaning from the ventilator, intensive care unit (I…
View article: Population genomics of postglacial western eurasia
Population genomics of postglacial western eurasia Open
Summary Western Eurasia witnessed several large-scale human migrations during the Holocene 1–5 . To investigate the cross-continental impacts we shotgun-sequenced 317 primarily Mesolithic and Neolithic genomes from across Northern and West…
Electrical stimulated GLUT4 signalling attenuates critical illness‐associated muscle wasting Open
Background Critical illness myopathy (CIM) is a debilitating condition characterized by the preferential loss of the motor protein myosin. CIM is a by‐product of critical care, attributed to impaired recovery, long‐term complications, and …
View article: The optimized quantum dot mediated thermometry reveals isoform specific differences in efficiency of myosin extracted from muscle mini bundles
The optimized quantum dot mediated thermometry reveals isoform specific differences in efficiency of myosin extracted from muscle mini bundles Open
The biophysical function of myosin in vitro has been extensively investigated in different motility assays, but the study of myosin ATPase properties at the fiber level is insufficiently investigated. In this study, quantum dot (QD) mediat…
Critical Illness Myopathy: Diagnostic Approach and Resulting Therapeutic Implications Open
Purpose of review Critical illness myopathy (CIM) is a common neuro-muscular complication of intensive care treatment associated with increased morbidity and mortality. The current guidelines for diagnosis include clinical and electrophysi…
Metabolomic Profiling of Respiratory Muscles and Lung in Response to Long-Term Controlled Mechanical Ventilation Open
Critical illness myopathy (CIM) and ventilator-induced diaphragm dysfunction (VIDD) are characterized by severe muscle wasting, muscle paresis, and extubation failure with subsequent increased medical costs and mortality/morbidity rates in…
Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement Open
Metabolism and movement, among the critical determinants in the survival and success of an organism, are tightly regulated by the brain and skeletal muscle. At the cellular level, mitochondria -that powers life, and myosin - the molecular …
Management of Complications After Skin Surgery Relevant for Melanoma in the Trunk and Extremities Under the COVID-19 Pandemic: A Case Series Report Open
Background: Patients with melanoma have been found to be at greater risk of adverse outcomes including mortality after contacting COVID-19. Management of postsurgical complications presented additional challenges by potentially increasing …
Electrical Stimulated GLUT4 Signaling Attenuates Critical Illness-Associated Muscle Wasting Open
Background Critical illness myopathy (CIM) is a debilitating condition characterized by the preferential loss of the motor protein myosin. CIM is a byproduct of critical care, attributed to impaired recovery, long‐term complications, and m…
View article: The Optimized Quantum Dots Mediated Thermometry Reveals the Efficiency of Myosin Extracted from Muscle Mini Bundles
The Optimized Quantum Dots Mediated Thermometry Reveals the Efficiency of Myosin Extracted from Muscle Mini Bundles Open
Background: The quantum dots (QD) has been investigated as thermometrical sensor in biological microenvironment and applied to measure the muscle efficiency with underlying mechanisms, i.e., a reduction in fluorescent intensity of QD refle…
Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Open
We here provide an overview of treatment trials for prolonged intensive care unit (ICU) patients and theorize about their relevance for potential treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these…
JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R Open
Key points Critical illness myopathy (CIM) is a frequently observed negative consequence of modern critical care. Chronic Janus kinase (JAK)/signal transducer and activator of transcription activation impairs muscle size and function and i…
Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Open
Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are:…
Additional file 5 of Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study Open
Additional file 5. Supplemental Table 4: Enriched KEGG pathways in the diaphragm.
Additional file 6 of Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study Open
Additional file 6. Supplemental Table 5: Enriched KEGG pathways in the plasma.
Additional file 3 of Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study Open
Additional file 3. Supplemental Table 2: CMV-induced DEPs in the plasma.