Sadayoshi Ito
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View article: Efficacy of Esaxerenone Plus a Renin–Angiotensin System Inhibitor or Calcium Channel Blocker for Nocturnal Hypertension: A Post Hoc Analysis
Efficacy of Esaxerenone Plus a Renin–Angiotensin System Inhibitor or Calcium Channel Blocker for Nocturnal Hypertension: A Post Hoc Analysis Open
BACKGROUND Nocturnal blood pressure (BP) is superior to daytime BP in predicting cardiovascular mortality. It is of clinical relevance to evaluate the effect of esaxerenone combination therapy on nighttime BP in patients with uncontrolled …
View article: Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases
Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases Open
DLRS-derived tubulo-interstitial injury scores are concordant with nephrologists' evaluations and correlated with eGFR across different populations and institutions. The effectiveness of DLRS-derived scores for predicting annual eGFR decli…
View article: Severe influenza A viral pneumonia in a hemodialysis patient: successful treatment with steroid pulse therapy
Severe influenza A viral pneumonia in a hemodialysis patient: successful treatment with steroid pulse therapy Open
Seasonal influenza is prevalent globally, particularly during winter months. It is well documented that this disease causes severe, often fatal complications in hemodialysis patients. While numerous reports have focused on novel influenza …
View article: Role of radiologists in the diagnosis and management of adrenal disorders
Role of radiologists in the diagnosis and management of adrenal disorders Open
This study aimed to focus on the role of radiologists in the diagnosis and management of adrenal lesions, particularly primary aldosteronism (PA) and secondary hypertension. As hypertension affects more than one-third of the population in …
View article: Long-term efficacy and safety of difelikefalin in moderate-to-severe pruritus in Japanese hemodialysis patients: a 52-week open-label extension period of a phase 3 trial
Long-term efficacy and safety of difelikefalin in moderate-to-severe pruritus in Japanese hemodialysis patients: a 52-week open-label extension period of a phase 3 trial Open
Background Difelikefalin, a potent and highly selective agonist of kappa opioid receptors, is used to treat moderate-to-severe pruritus in hemodialysis patients. Methods This was a 52-week, open-label phase 3 trial following a 6-week rando…
View article: Screening Cutoff Values for the Detection of Aldosterone-Producing Adenoma by LC-MS/MS and a Novel Noncompetitive CLEIA
Screening Cutoff Values for the Detection of Aldosterone-Producing Adenoma by LC-MS/MS and a Novel Noncompetitive CLEIA Open
Context Detecting patients with surgically curable aldosterone-producing adenoma (APA) among hypertensive individuals is clinically pivotal. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) is the ideal method of measuring plasma …
View article: Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes
Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes Open
Importance Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. Objective To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based …
View article: Supplementary Material for: Pulmonary Artery Intimal Sarcoma in a Patient with Lynch Syndrome: Response to an Immune Checkpoint Inhibitor
Supplementary Material for: Pulmonary Artery Intimal Sarcoma in a Patient with Lynch Syndrome: Response to an Immune Checkpoint Inhibitor Open
Intimal sarcoma is an extremely rare mesenchymal tumor arising in the great vessels. To date, intimal sarcoma has not been reported in patients with Lynch syndrome (LS), even though this syndrome lacks DNA mismatch repair ability genetical…
View article: Supplementary Material for: Pulmonary Artery Intimal Sarcoma in a Patient with Lynch Syndrome: Response to an Immune Checkpoint Inhibitor
Supplementary Material for: Pulmonary Artery Intimal Sarcoma in a Patient with Lynch Syndrome: Response to an Immune Checkpoint Inhibitor Open
Intimal sarcoma is an extremely rare mesenchymal tumor arising in the great vessels. To date, intimal sarcoma has not been reported in patients with Lynch syndrome (LS), even though this syndrome lacks DNA mismatch repair ability genetical…
View article: Supplementary Material for: Proposal of the second cutoff of serum carcinoembryonic antigen levels to stratify patients into low, intermediate, and high risks at recurrences after curative resection of gastric cancer
Supplementary Material for: Proposal of the second cutoff of serum carcinoembryonic antigen levels to stratify patients into low, intermediate, and high risks at recurrences after curative resection of gastric cancer Open
Introduction: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are widely used for various cancers, with the cut-off values of 5.0 ng/mL and 37.0 IU/mL, respectively. However, these cutoff values are not for specific d…
View article: Supplementary Material for: Pure red cell aplasia induced by atezolizumab in a patient with small cell lung cancer successfully treated with steroid therapy: a case report
Supplementary Material for: Pure red cell aplasia induced by atezolizumab in a patient with small cell lung cancer successfully treated with steroid therapy: a case report Open
Introduction: Combination therapy of atezolizumab and chemotherapy has become the standard treatment for small-cell lung cancer. Immune-related adverse events (irAEs) can occur during immune checkpoint inhibitor administration. A few repor…
View article: Supplementary Material for: Proposal of the second cutoff of serum carcinoembryonic antigen levels to stratify patients into low, intermediate, and high risks at recurrences after curative resection of gastric cancer
Supplementary Material for: Proposal of the second cutoff of serum carcinoembryonic antigen levels to stratify patients into low, intermediate, and high risks at recurrences after curative resection of gastric cancer Open
Introduction: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are widely used for various cancers, with the cut-off values of 5.0 ng/mL and 37.0 IU/mL, respectively. However, these cutoff values are not for specific d…
View article: Supplementary Material for: Proposal of the second cutoff of serum carcinoembryonic antigen levels to stratify patients into low, intermediate, and high risks at recurrences after curative resection of gastric cancer
Supplementary Material for: Proposal of the second cutoff of serum carcinoembryonic antigen levels to stratify patients into low, intermediate, and high risks at recurrences after curative resection of gastric cancer Open
Introduction: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are widely used for various cancers, with the cut-off values of 5.0 ng/mL and 37.0 IU/mL, respectively. However, these cutoff values are not for specific d…
View article: Supplementary Material for: Pulmonary Artery Intimal Sarcoma in a Patient with Lynch Syndrome: Response to an Immune Checkpoint Inhibitor
Supplementary Material for: Pulmonary Artery Intimal Sarcoma in a Patient with Lynch Syndrome: Response to an Immune Checkpoint Inhibitor Open
Intimal sarcoma is an extremely rare mesenchymal tumor arising in the great vessels. To date, intimal sarcoma has not been reported in patients with Lynch syndrome (LS), even though this syndrome lacks DNA mismatch repair ability genetical…
View article: Supplementary Material for: Exocrine pancreatic insufficiency possibly related to atypical chronic graft-versus-host disease
Supplementary Material for: Exocrine pancreatic insufficiency possibly related to atypical chronic graft-versus-host disease Open
We report the case of a 66-year-old woman who presented with diarrhea and weight loss approximately fourteen months after unrelated allogeneic bone marrow transplantation for acute myeloid leukemia. Her early post-transplant course was not…
View article: The renoprotective effect of esaxerenone independent of blood pressure lowering: a post hoc mediation analysis of the ESAX-DN trial
The renoprotective effect of esaxerenone independent of blood pressure lowering: a post hoc mediation analysis of the ESAX-DN trial Open
Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) are recommended as first-line drugs for hypertension with diabetic nephropathy owing to their renoprotective effect; however, their effect beyond low…
View article: The Time to Reconsider Mineralocorticoid Receptor Blocking Strategy: Arrival of Nonsteroidal Mineralocorticoid Receptor Blockers
The Time to Reconsider Mineralocorticoid Receptor Blocking Strategy: Arrival of Nonsteroidal Mineralocorticoid Receptor Blockers Open
Purpose of Review The study aims to verify the advantages of nonsteroidal mineralocorticoid receptor blockers (MRBs) in the management of hypertension and cardiovascular and renal diseases, comparing with conventional MRBs. Recent Findings…
View article: Safety and Feasibility of Radiofrequency Ablation Using Bipolar Electrodes for Aldosterone-Producing Adenoma: A Multicentric Prospective Clinical Study
Safety and Feasibility of Radiofrequency Ablation Using Bipolar Electrodes for Aldosterone-Producing Adenoma: A Multicentric Prospective Clinical Study Open
Purpose: Evaluation of feasibility and safety of percutaneous radiofrequency ablation (RFA) using bipolar radiofrequency (RF) devices in a prospective multicenter cohort of patients with benign aldosterone-producing adenoma (APA). Methods:…
View article: Reduction in the magnitude of serum potassium elevation in combination therapy with esaxerenone (CS‐3150) and sodium–glucose cotransporter 2 inhibitor in patients with diabetic kidney disease: Subanalysis of two phase III studies
Reduction in the magnitude of serum potassium elevation in combination therapy with esaxerenone (CS‐3150) and sodium–glucose cotransporter 2 inhibitor in patients with diabetic kidney disease: Subanalysis of two phase III studies Open
Aims/Introduction We evaluated the effect of co‐administration of esaxerenone and a sodium–glucose cotransporter 2 (SGLT2) inhibitor on the magnitude of serum potassium elevation in Japanese patients with diabetic kidney disease. Materials…
View article: Supplementary Material for: Radiation Myelopathy Caused by Palliative Radiotherapy and Intrathecal Methotrexate
Supplementary Material for: Radiation Myelopathy Caused by Palliative Radiotherapy and Intrathecal Methotrexate Open
Radiation myelopathy is a rare, late-stage adverse event that develops following irradiation at or above 50 Gy. Here, we report a case of irreversible paraplegia caused by palliative radiation (20 Gy in 5 fractions) to the spinal cord comb…
View article: Supplementary Material for: Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy
Supplementary Material for: Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy Open
Introduction: In diabetic nephropathy (DN), mitochondrial dysfunction and leakage of mitochondrial DNA (mtDNA) are caused by the downregulation of superoxide dismutase 2 (SOD2). mtDNA induces the activation of Toll-like receptor (TLR) 9, w…
View article: dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project Open
To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establ…
View article: Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies
Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies Open
Background It is uncertain whether risk classification under the nationwide program on screening and lifestyle modification for metabolic syndrome captures well high‐risk individuals who could benefit from lifestyle interventions. We exami…
View article: Effect of esaxerenone on nocturnal blood pressure and natriuretic peptide in different dipping phenotypes
Effect of esaxerenone on nocturnal blood pressure and natriuretic peptide in different dipping phenotypes Open
There are limited data on the nighttime blood pressure (BP)-lowering effect of esaxerenone and its effect on N-terminal pro b-type natriuretic peptide (NT-proBNP), a predictor of cardiovascular risk, according to different dipping patterns…