Ingo Müller
YOU?
Author Swipe
View article: Addressing Visual Impairments with Model-Driven Engineering: A Systematic Literature Review
Addressing Visual Impairments with Model-Driven Engineering: A Systematic Literature Review Open
Software applications often pose barriers for users with accessibility needs, e.g., visual impairments. Model-driven engineering (MDE), with its systematic nature of code derivation, offers systematic methods to integrate accessibility con…
View article: Late effects after hematopoietic stem cell transplantation in patients with HLH: A Histiocyte Society, PDWP, IEWP, and TCWP EBMT Study
Late effects after hematopoietic stem cell transplantation in patients with HLH: A Histiocyte Society, PDWP, IEWP, and TCWP EBMT Study Open
HCT has significantly improved survival in patients with pHLH. However, survivors still face significant risks of LEs.
View article: GD2-CAR NK-92 cell activity against neuroblastoma cells is insusceptible to TIGIT knockout
GD2-CAR NK-92 cell activity against neuroblastoma cells is insusceptible to TIGIT knockout Open
Immunotherapy by inhibition of immune checkpoint (IC) molecules has emerged as an important cancer therapy. Among these lC, the poliovirus receptor/poliovirus receptor-like 2 protein (PVR/PVRL2)-TIGIT axis was discovered as potential targe…
View article: Dissolved organic carbon in a drinking water catchment in the western Ore Mountains, Germany: How much, Where from, When and Why – first insights
Dissolved organic carbon in a drinking water catchment in the western Ore Mountains, Germany: How much, Where from, When and Why – first insights Open
Increasing concentrations of dissolved organic carbon (DOC) in tributaries threaten the water quality of drinking water reservoirs in Europe and North America. Understanding the key factors influencing DOC dynamics in streams is essential …
View article: Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma
Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma Open
Background/Objectives: Neuroblastoma is a highly aggressive pediatric cancer that arises from immature nerve cells and exhibits a broad spectrum of clinical presentations. While low- and intermediate-risk neuroblastomas often have favorabl…
View article: Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation
Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation Open
Toleration of a semi-allogeneic fetus in the mother’s uterus as well as tolerance after allogeneic hematopoietic stem cell transplantation (HSCT) appear to share some immunologic concepts. The existence of microchimeric cells, and the orig…
View article: Case report: Granulocyte-macrophage colony-stimulating factor sargramostim did not rescue the neutrophil phenotype in two patients with JAGN1-mutant severe congenital neutropenia
Case report: Granulocyte-macrophage colony-stimulating factor sargramostim did not rescue the neutrophil phenotype in two patients with JAGN1-mutant severe congenital neutropenia Open
Background Homozygous or compound heterozygous mutations in JAGN1 cause severe congenital neutropenia. JAGN1-mutant patients present with severe early-onset bacterial infections and most have been described as low-responders to recombinant…
View article: Haematopoietic stem cell transplantation after reduced intensity conditioning in children and adolescents with chronic myeloid leukaemia: A prospective multicentre trial of the <scp>I‐BFM</scp> Study Group
Haematopoietic stem cell transplantation after reduced intensity conditioning in children and adolescents with chronic myeloid leukaemia: A prospective multicentre trial of the <span>I‐BFM</span> Study Group Open
Summary This prospective multicentre trial evaluated the safety and the efficacy of a thiotepa/melphalan‐based reduced intensity conditioning (RIC) haematopoietic stem cell transplantation (HSCT) in children and adolescents with chronic my…
View article: Glycan Structures in Osteosarcoma as Targets for Lectin-Based Chimeric Antigen Receptor Immunotherapy
Glycan Structures in Osteosarcoma as Targets for Lectin-Based Chimeric Antigen Receptor Immunotherapy Open
Osteosarcoma is a type of bone cancer that primarily affects children and young adults. The overall 5-year survival rate for localized osteosarcoma is 70–75%, but it is only 20–30% for patients with relapsed or metastatic tumors. To invest…
View article: Increasing stream water DOC concentrations in peat-affected catchments: insights from high-resolution water quality analysis
Increasing stream water DOC concentrations in peat-affected catchments: insights from high-resolution water quality analysis Open
Peatlands are an important natural terrestrial carbon sink. Any impact on the drivers of hydro-biogeochemical processes in these ecosystems can be particularly severe. Climate change and degradation by drainage and ditching are dramaticall…
View article: Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression
Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression Open
We performed a retrospective analysis on 124 patients with transfusion-dependent thalassemia who were registered in the German pediatric registry for stem cell transplantation. All patients underwent first allogeneic hematopoietic stem cel…
View article: S111: TREATMENT OF POST-TRANSPLANT RELAPSE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH BCP ALL USING CD19-CAR-T: A EUROPEAN RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA
S111: TREATMENT OF POST-TRANSPLANT RELAPSE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH BCP ALL USING CD19-CAR-T: A EUROPEAN RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA Open
Background: Relapse after allogeneic hematopoietic stem cell transplantation (SCT) for very high-risk acute lymphoblastic leukemia (ALL) has a dismal prognosis. The potentially curative effect of a second SCT is jeopardized by a high rate …
View article: ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH REDUCED‐TOXICITY CONDITIONING FOR PEDIATRIC RELAPSED OR REFRACTORY ALK‐POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH REDUCED‐TOXICITY CONDITIONING FOR PEDIATRIC RELAPSED OR REFRACTORY ALK‐POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA Open
Introduction: For children and adolescents with refractory or relapsed (r/r) anaplastic large cell lymphoma (ALCL), consolidation by allogeneic hematopoietic stem cell transplantation (SCT) after re-induction chemotherapy offers long-time …
View article: Electrodynamics and rational thermodynamics
Electrodynamics and rational thermodynamics Open
The electromagnetic fields ( D , H ) represent contravariant components of an antisymmetric 4‐tensor, while the fields ( E , B ) represent covariant components of the same 4‐tensor. Both sets are identical in Lorentz frames. The governing …
View article: Epigenetic Modification of Mesenchymal Stromal Cells Derived from Bone Marrow and Embryonal Tumors to Facilitate Immunotherapeutic Approaches in Pediatric Malignancies
Epigenetic Modification of Mesenchymal Stromal Cells Derived from Bone Marrow and Embryonal Tumors to Facilitate Immunotherapeutic Approaches in Pediatric Malignancies Open
Mesenchymal stromal cells (MSC) are part of the bone marrow architecture and contribute to the homeostasis of hematopoietic stem cells. Moreover, they are known to regulate immune effector cells. These properties of MSC are pivotal under p…
View article: What causes rising DOC concentrations in streams from peat-affected catchments? Insights with high-resolution water quality analysis
What causes rising DOC concentrations in streams from peat-affected catchments? Insights with high-resolution water quality analysis Open
Peatlands are an important natural terrestrial carbon store. Any impacts on the drivers of hydro-biogeochemical processes in these ecosystems can be particularly severe. Climate change and degradation through drainages and ditches are chan…
View article: CD19 CAR T cells are an effective therapy for posttransplant relapse in patients with B-lineage ALL: real-world data from Germany
CD19 CAR T cells are an effective therapy for posttransplant relapse in patients with B-lineage ALL: real-world data from Germany Open
Patients with precursor B-cell acute lymphoblastic leukemia (pB-ALL) who have relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT), have relapsed more than once, or are resistant upfront have a dismal prognosis. CD…
View article: Immune Ablation and Stem Cell Rescue in Two Pediatric Patients with Progressive Severe Chronic Graft-Versus-Host Disease
Immune Ablation and Stem Cell Rescue in Two Pediatric Patients with Progressive Severe Chronic Graft-Versus-Host Disease Open
Transplantation of allogeneic hematopoietic stem cells represents an established treatment for children with high-risk leukemia. However, steroid-refractory chronic graft-versus-host disease (SR-cGvHD) represents a severe life-threatening …
View article: MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity
MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity Open
Most hereditary forms of hemophagocytic lymphohistiocytosis (HLH) are caused by defects of cytotoxicity, including the vesicle trafficking disorder Griscelli syndrome type 2 (GS2, RAB27A deficiency). Deficiency of the mitogen-activated pro…
View article: Long-Term Antibody Response to SARS-CoV-2 in Children
Long-Term Antibody Response to SARS-CoV-2 in Children Open
Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation …
View article: On the Heat Death and the Big Crunch
On the Heat Death and the Big Crunch Open
This article is an exercise in elementary mechanics and thermodynamics. It emphasizes the basic difference between mechanics and thermodynamics which lies in the irreversibility of the latter theory. Clausius [1] (Poggendorff’s Annalen der…
View article: Resource Allocation in Serverless Query Processing
Resource Allocation in Serverless Query Processing Open
Data lakes hold a growing amount of cold data that is infrequently accessed, yet require interactive response times. Serverless functions are seen as a way to address this use case since they offer an appealing alternative to maintaining (…
View article: Drivers of spatial and temporal variability of dissolved organic matter across the terrestrial&#8722;aquatic continuum
Drivers of spatial and temporal variability of dissolved organic matter across the terrestrial−aquatic continuum Open
<p>Dissolved organic matter (DOM) is an important component in carbon and nutrient cycles in terrestrial and aquatic ecosystems. For three decades, concentrations of dissolved organic carbon (DOC) have been increasing in European and…
View article: The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age
The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age Open
Hematopoietic stem cell transplantation (HSCT) represents the only curative treatment option for numerous hematologic malignancies. While the influence of donor age and the composition of the graft have already been examined in clinical an…
View article: Comparison of single copy gene‑based duplex quantitative PCR and digital droplet PCR for monitoring of expansion of CD19‑directed CAR T cells in treated patients
Comparison of single copy gene‑based duplex quantitative PCR and digital droplet PCR for monitoring of expansion of CD19‑directed CAR T cells in treated patients Open
Chimeric antigen receptor (CAR) T cell therapy with axicabtagene ciloleucel, tisagenlecleucel and brexucabtagen ciloleucel has been adopted as the standard of care for patients with refractory and/or relapsed CD19‑positive lymphoid maligna…
View article: Influence of Fetomaternal Microchimerism on Maternal NK Cell Reactivity against the Child’s Leukemic Blasts
Influence of Fetomaternal Microchimerism on Maternal NK Cell Reactivity against the Child’s Leukemic Blasts Open
Persistence of fetal cells in the circulation of the mother (fetal microchimerism, FM) is associated with increased survival and reduced relapse of children with leukemia receiving a haploidentical hematopoietic stem cell transplantation (…
View article: NET Release of Long-Term Surviving Neutrophils
NET Release of Long-Term Surviving Neutrophils Open
Background Neutrophil extracellular traps (NETs)—as double-edged swords of innate immunity—are involved in numerous processes such as infection, inflammation and tissue repair. Research on neutrophil granulocytes is limited because of thei…