I. N. Sychev
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View article: Diagnosis and antimicrobial therapy of infections caused by polyresistant microorganisms (updated 2024)
Diagnosis and antimicrobial therapy of infections caused by polyresistant microorganisms (updated 2024) Open
Strains of microorganisms characterized by resistance to antimicrobial drugs used in medical organizations continue to spread in most regions of the world, including Russia. This naturally affects both the effectiveness of antimicrobial th…
View article: Single-point multicenter survey of using antimicrobial drugs in the ICUs of Russian multidisciplinary hospitals: results of the Global-PPS 2022 project
Single-point multicenter survey of using antimicrobial drugs in the ICUs of Russian multidisciplinary hospitals: results of the Global-PPS 2022 project Open
Introduction. The marked increase in the resistance of infectious disease pathogens to antimicrobial drugs (AMDs), especially in intensive care units (ICUs), poses a threat to healthcare systems worldwide. This leads to adverse consequence…
View article: Clinical and economic evaluation of antibacterial therapy for nosocomial pneumonia on the example of a multidisciplinary hospital in Moscow
Clinical and economic evaluation of antibacterial therapy for nosocomial pneumonia on the example of a multidisciplinary hospital in Moscow Open
Objective: To conduct a clinical and economic analysis of antibacterial therapy for severe nosocomial pneumonia within the context of real clinical practice at a multidisciplinary hospital in Moscow. Material and methods. The medical recor…
View article: The significance of monitoring respiratory sample cultures and polymerase chain reaction tests for detecting bacterial pathogens in severely and critically ill patients with COVID-19
The significance of monitoring respiratory sample cultures and polymerase chain reaction tests for detecting bacterial pathogens in severely and critically ill patients with COVID-19 Open
Background. Bacterial superinfection is one of the most common and potentially lethal complications in severely and critically ill patients with COVID-19. Objectives. To determine the colonisation time frame and the spectrum of potential b…
View article: A pilot study of the clinical significance and outcomes of infections in the ICU caused by colistin-resistant Klebsiella pneumoniae
A pilot study of the clinical significance and outcomes of infections in the ICU caused by colistin-resistant Klebsiella pneumoniae Open
The objective was to study the risk factors, outcomes of infections caused by colistin-resistant K. pneumonia (CRKP) and to evaluate the sensitivity of these microorganisms to antibacterial agents to determine the most adequate antibiotic …
View article: Effect of CYP3A4/5, ABCB1 gene polymorphisms on the residual equilibrium concentration of apixaban and bleeding in patients with non-valvular atrial fibrillation and deep vein thrombosis
Effect of CYP3A4/5, ABCB1 gene polymorphisms on the residual equilibrium concentration of apixaban and bleeding in patients with non-valvular atrial fibrillation and deep vein thrombosis Open
Aim . The aim of our study was to investigate the influence of polymorphic markers of CYP3A4*22 CYP3A4*22 ( c.522-191C>T, rs35599367 ), CYP3A5*3 ( c.219 237A>G, rs776746 ), ABCB1 rs1045642 ( c.3435T>C ) and rs4148738 ( c.2692-2236C>T ) gen…
View article: Difficulties in choosing antibacterial therapy regimen for nosocomial pneumonia in intensive care units: clinical observations
Difficulties in choosing antibacterial therapy regimen for nosocomial pneumonia in intensive care units: clinical observations Open
Nosocomial pneumonia is one of the most common healthcare-associated infections and the most frequent in intensive care unit (ICU) patients. The clinical and economic consequences of nosocomial pneumonia are very significant, especially fo…
View article: Diagnosis and antibiotic therapy of nosocomial pneumonia in adults: from recommendations to real practice. A review
Diagnosis and antibiotic therapy of nosocomial pneumonia in adults: from recommendations to real practice. A review Open
Nosocomial pneumonia is a healthcare-associated infection with significant consequences for the patient and the healthcare system. The efficacy of treatment significantly depends on the timeliness and adequacy of the antibiotic therapy reg…
View article: Anticoagulant therapy with apixaban based on a pharmacogenetic approach: a course to safety
Anticoagulant therapy with apixaban based on a pharmacogenetic approach: a course to safety Open
For the past 60 years, vitamin K antagonists (VKAs) have been the main drugs used for long-term oral anticoagulant therapy. Because of the significant limitations of AVCs, direct-acting oral anticoagulants (DOAKs) have been developed over …
View article: Clinical and pharmacological approaches to personalization of the prescription of oral anticoagulants: clinical cases
Clinical and pharmacological approaches to personalization of the prescription of oral anticoagulants: clinical cases Open
Anticoagulants play an important role in reducing complications and mortality associated with thromboembolic disease. For some time, vitamin K antagonists (VKAs) have been the main drugs used for long-term oral anticoagulant therapy, but b…
View article: Analysis of the structure of bacteremia and sensitivity to antibiotics of microorganisms isolated in intensive care units in an emergency hospital in the period from 2003 to 2021: a retrospective observational study
Analysis of the structure of bacteremia and sensitivity to antibiotics of microorganisms isolated in intensive care units in an emergency hospital in the period from 2003 to 2021: a retrospective observational study Open
INTRODUCTION: Creation of protocols for effective empiric antimicrobial therapy is impossible without the analysis of current antibiotic susceptibility data. OBJECTIVE: Analysis of changes in the etiological significance of the leading pat…
View article: The First Experience of Combined Use of Cefepime/Sulbactam and Aztreonam in ICU Patients with Nosocomial Infections Caused by Carbapenem-Resistant Gram-Negative Microorganisms Producing Class B and D Carbapenemases
The First Experience of Combined Use of Cefepime/Sulbactam and Aztreonam in ICU Patients with Nosocomial Infections Caused by Carbapenem-Resistant Gram-Negative Microorganisms Producing Class B and D Carbapenemases Open
Background . The difficulties of antibacterial therapy of infections caused by carbapenemase-producing gram-negative bacteria are associated with limited options for adequate therapy since, in addition to resistance to carbapenems and other …
View article: Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis
Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis Open
Aim . To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial fibrillation and deep vein thrombosis. Material and methods . Patients hospitalize…
View article: Point prevalence multicenter survey of antimicrobial consumption in Russian hospitals: results of the Global-PPS 2021
Point prevalence multicenter survey of antimicrobial consumption in Russian hospitals: results of the Global-PPS 2021 Open
Objective. To evaluate prescribing patterns of antimicrobials and quantify them in relation to quality indicators in Russian multi-field hospitals. Materials and Methods. Point Prevalence Survey of Antimicrobial Consumption as a part of an…
View article: Anticoagulant therapy with direct oral anticoagulants in the context of polypragmasy: a course to safety
Anticoagulant therapy with direct oral anticoagulants in the context of polypragmasy: a course to safety Open
Cardiovascular disease is the most common cause of death in the world. For almost 60 years vitamin K antagonists (VKAs) have been the mainstay of anticoagulant therapy, but in recent years direct oral anticoagulants (DAACs) have become the…
View article: Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project Open
The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global…
View article: Importance of using a pharmacogenetic approach to predict individual pharmacokinetics and safety profile of apixaban
Importance of using a pharmacogenetic approach to predict individual pharmacokinetics and safety profile of apixaban Open
In recent years, there has been a trend towards increased prescribing of direct-acting oral anticoagulants (DOACs) due to favourable pharmacokinetics and pharmacodynamics without the need for regular coagulation monitoring. However, recent…
View article: Microbiological monitoring of COVID-19 patients in the ICU: a prospective observational study
Microbiological monitoring of COVID-19 patients in the ICU: a prospective observational study Open
Objective. To study spectrum of pathogens and the time to colonization of respiratory samples in patients with severe and critical COVID-19 as well as to analyze incidence of nosocomial infections and structure of prescribed antibacterial …
View article: Effect of polymorphisms in CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G, ABCB1 (rs4148738) C>T and ABCB1 (rs1045642) C>T genes on apixaban anticoagulation: pilot study results
Effect of polymorphisms in CYP3A4*22 (rs35599367) C>T, CYP3A5*3 (rs776746) A>G, ABCB1 (rs4148738) C>T and ABCB1 (rs1045642) C>T genes on apixaban anticoagulation: pilot study results Open
Introduction . Apixaban is a direct oral anticoagulant prescribed for treatment and prevention of venous thromboembolism (VTE) and for prevention of stroke in patients with nonvalvular atrial fibrillation. Direct oral anticoagulants (DOACs…
View article: An Open-Label, Multicenter, Observational Study of The Effectiveness of The Cefepime/Sulbactam Antibiotic (Maxictam<sup>®</sup>-AF) In Patients With Intra Abdominal Infection, Nosocomial Pneumonia or Ventilator-Associated Pneumonia (Study MAXI-2019)
An Open-Label, Multicenter, Observational Study of The Effectiveness of The Cefepime/Sulbactam Antibiotic (Maxictam<sup>®</sup>-AF) In Patients With Intra Abdominal Infection, Nosocomial Pneumonia or Ventilator-Associated Pneumonia (Study MAXI-2019) Open
The aim of the study was to evaluate the effectiveness of cefepime/sulbactam in patients with intra-abdominal infection, nosocomial pneumonia (NP) or ventilator-associated pneumonia (VAP) in actual clinical practice. Material and methods. …
View article: Antibiotic therapy under polypragmatic conditions: a course to safety
Antibiotic therapy under polypragmatic conditions: a course to safety Open
Prescribing safe and effective drug therapy is becoming increasingly challenging. Recently, there has been an upward trend in the number of patients experiencing polypragmasy. Thus, according to epidemiological analysis of 180,815 outpatie…
View article: Antibiotic therapy under polypragmatic conditions: a course to safety
Antibiotic therapy under polypragmatic conditions: a course to safety Open
Prescribing safe and effective drug therapy is becoming increasingly challenging. Recently, there has been an upward trend in the number of patients experiencing polypragmasy. Thus, according to epidemiological analysis of 180,815 outpatie…
View article: The CES1 Gene rs2244613 Minor Allele Impact on the Safety Profile of Dabigatran Etexilate: Meta-Analysis
The CES1 Gene rs2244613 Minor Allele Impact on the Safety Profile of Dabigatran Etexilate: Meta-Analysis Open
Aim . A meta-analysis of studies on the CES1 gene c.1168-33A>C polymorphism (rs2244613) carriage influence on the equilibrium concentration and the risk of bleeding during dabigatran taking. Material and methods . The search was carried ou…
View article: Current and future use of vitamin D<sub>3</sub> in patients with COVID-19
Current and future use of vitamin D<sub>3</sub> in patients with COVID-19 Open
There is currently no evidence for vitamin D3 effectiveness for COVID-19 treatment and prevention.
View article: Current and future use of umifenovir in patients with COVID-19
Current and future use of umifenovir in patients with COVID-19 Open
At the time of print, the evidence for using umifenovir in COVID-19 is mainly theoretical. The published clinical trials have contradicting results. The decision to use umifenovir in COVID-19 should be individualized, considering the “expe…
View article: Use of etiotropic and pathogenetic medicines for COVID-19 in patients with renal failure and/or on dialysis
Use of etiotropic and pathogenetic medicines for COVID-19 in patients with renal failure and/or on dialysis Open
Impaired kidney function may influence pharmacokinetics of most of the drugs, including the ones used in COVID-19. In this publication, the most important pharmacokinetic parameters and dose adjustment approaches are provided, based on The…
View article: New Pharmacogenetic Markers to Predict the Risk of Bleeding During Taking of Direct Oral Anticoagulants
New Pharmacogenetic Markers to Predict the Risk of Bleeding During Taking of Direct Oral Anticoagulants Open
Aim . To search for new pharmacogenetic biomarkers of bleeding risk in patients taking rivaroxaban and dabigatran for different indications: atrial fibrillation, endoprosthesis of large joints of lower limbs. Material and methods . The stu…
View article: Dosing of antibiotics in patients with sepsis, including those undergoing renal replacement therapy
Dosing of antibiotics in patients with sepsis, including those undergoing renal replacement therapy Open
In critically ill patients the adequacy of starting empirical antimicrobial therapy is a determining factor of the survival of patients with sepsis This article describes the main aspects of the empirical prescription of antibiotics in pat…
View article: Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants
Clinical pharmacology technologies for personalization of cardiovascular diseases drug treatment: focus on direct oral anticoagulants Open
One of the main causes for adverse reactions development is not taking into account the pharmacokinetics of drugs and the dose. Pharmacokinetics of drugs is mostly defined by the cytochrome P-450 isoenzymes activity, carboxylesterases and …
View article: Современные проблемы инфекций, вызванных MRSA и пути их решения
Современные проблемы инфекций, вызванных MRSA и пути их решения Open
The increase in the growth rate of MRSA as an etiologic factor has been recorded worldwide in recent years. The main problem of antibiotic resistance in Staphylococcus aureus is its resistance to beta-lactam antibiotics. Previously, MRSA h…