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View article: The eIF5A hypusination inhibitor GC7 improves tolerance of pancreatic beta cells to ischemia/reperfusion
The eIF5A hypusination inhibitor GC7 improves tolerance of pancreatic beta cells to ischemia/reperfusion Open
Transplantation of pancreatic islets, containing insulin secreting beta cells, provides substantial benefits for individuals with Type 1 Diabetes (T1D). However, the low yield of the procedure limits its therapeutic potential, as many isle…
View article: Inhibition of eIF5A hypusination enhances antioxidant defense to prevent kidney Ischemia/Reperfusion injury
Inhibition of eIF5A hypusination enhances antioxidant defense to prevent kidney Ischemia/Reperfusion injury Open
View article: Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke – Insights from a proof-of-concept study
Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke – Insights from a proof-of-concept study Open
Stroke imposes significant global socio-economic burdens, yet the absence of clinically approved anti-ischemic drugs and limited thrombolysis availability underscore the critical need for novel therapeutic target. To identify novel anti-is…
View article: Correction: The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate
Correction: The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate Open
View article: Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes
Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes Open
View article: The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate
The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate Open
View article: The 33<sup>rd</sup> Ion Channels Meeting, September 2024, Sète, France
The 33<sup>rd</sup> Ion Channels Meeting, September 2024, Sète, France Open
The 33rd Ion Channels Meeting has been held in Sète, France, from September 8th to 11th. The congress gathered together senior and junior researchers from almost all over the world working on different fiel…
View article: Proximal Tubular Deletion of Superoxide Dismutase-2 Reveals Disparate Effects on Kidney Function in Diabetes
Proximal Tubular Deletion of Superoxide Dismutase-2 Reveals Disparate Effects on Kidney Function in Diabetes Open
View article: Activation of osmo-sensitive LRRC8 anion channels in macrophages is important for micro-crystallin joint inflammation
Activation of osmo-sensitive LRRC8 anion channels in macrophages is important for micro-crystallin joint inflammation Open
View article: Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease Open
View article: A Plasma Pyrophosphate Cutoff Value for Diagnosing Pseudoxanthoma Elasticum
A Plasma Pyrophosphate Cutoff Value for Diagnosing Pseudoxanthoma Elasticum Open
Pseudoxanthoma elasticum (PXE) is a rare inherited systemic disease responsible for a juvenile peripheral arterial calcification disease. The clinical diagnosis of PXE is only based on a complex multi-organ phenotypic score and/or genetica…
View article: The 32nd Ion Channels Meeting, 17th–20th September 2023, Sète, France
The 32nd Ion Channels Meeting, 17th–20th September 2023, Sète, France Open
The 32nd Ion Channel Meetings were organized by the Ion Channels Association from September 17 to 20, 2023 in the Occitanie region (Sète). Researchers, post-docs and students from France, Europe and non-European countries came together to …
View article: OP0095 MONOSODIUM URATE AND CALCIUM PYROPHOSPHATE CRYSTAL-INDUCED INFLAMMATION RELIES ON CELL VOLUME REGULATION AND LRRRC8/VRAC CHANNEL ACTIVATION
OP0095 MONOSODIUM URATE AND CALCIUM PYROPHOSPHATE CRYSTAL-INDUCED INFLAMMATION RELIES ON CELL VOLUME REGULATION AND LRRRC8/VRAC CHANNEL ACTIVATION Open
View article: Supplementary Movie 2 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 2 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 875K, Video 2 (related to Fig. 2D) shows the delayed abscission of an a3-/- cell that remained connected by an intracellular bridge for up to 8 h 45 min before separating.
View article: Supplementary Movie 1 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 1 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 718K, Video 1 (related to Fig. 2A) is a time-lapse recording showing the normal cell division of control wild-type (WT) cells. In the last frame, the daughter WT cells are outlined in white to help visualize their successful div…
View article: Supplementary Movie 6 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 6 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 645K, Video 6 (related to Fig. 6A) is a time-lapse recording showing that the ATG5-depleted A549 cells formed numerous ectopic furrows in addition to a wider-than-normal equatorial cleavage furrow.
View article: Supplementary Figures 1 - 8 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Figures 1 - 8 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
PDF file - 3250K
View article: Data from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Data from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
Degradation of signaling proteins is one of the most powerful tumor-suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifica…
View article: Data from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Data from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
Degradation of signaling proteins is one of the most powerful tumor-suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifica…
View article: Supplementary Movie 2 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 2 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 875K, Video 2 (related to Fig. 2D) shows the delayed abscission of an a3-/- cell that remained connected by an intracellular bridge for up to 8 h 45 min before separating.
View article: Supplementary Movie 3 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 3 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 2696K, Video 3 (related to Fig. 2E) is a time-lapse recording of four pairs of a3-/- cells that entered mitosis synchronously, likely bridged sister cells. Pairs of cells that entered mitosis synchronously are outlined in color …
View article: Supplementary Figures 1 - 8 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Figures 1 - 8 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
PDF file - 3250K
View article: Supplementary Movie 3 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 3 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 2696K, Video 3 (related to Fig. 2E) is a time-lapse recording of four pairs of a3-/- cells that entered mitosis synchronously, likely bridged sister cells. Pairs of cells that entered mitosis synchronously are outlined in color …
View article: Supplementary Movie 4 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 4 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 2112K, Video 4 (related to Fig. 2F) illustrates the failed abscission of a mononucleated a3-/- cell that exited mitosis as a binucleated cell after 18 attempts at cleavage furrow formation. Note that this cell developed ectopic …
View article: Supplementary Movie 6 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 6 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 645K, Video 6 (related to Fig. 6A) is a time-lapse recording showing that the ATG5-depleted A549 cells formed numerous ectopic furrows in addition to a wider-than-normal equatorial cleavage furrow.
View article: Supplementary Movie 5 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 5 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 5901K, Video 5 (related to Fig. 2G) is a time-lapse recording of a mononucleate a3-/- cell that formed a tetranucleate cell after two rounds of abortive mitosis.
View article: Supplementary Movie 5 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 5 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 5901K, Video 5 (related to Fig. 2G) is a time-lapse recording of a mononucleate a3-/- cell that formed a tetranucleate cell after two rounds of abortive mitosis.
View article: Supplementary Movie 1 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 1 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 718K, Video 1 (related to Fig. 2A) is a time-lapse recording showing the normal cell division of control wild-type (WT) cells. In the last frame, the daughter WT cells are outlined in white to help visualize their successful div…
View article: Supplementary Movie 4 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
Supplementary Movie 4 from Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability Open
AVI file - 2112K, Video 4 (related to Fig. 2F) illustrates the failed abscission of a mononucleated a3-/- cell that exited mitosis as a binucleated cell after 18 attempts at cleavage furrow formation. Note that this cell developed ectopic …
View article: Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress
Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress Open
Through kidney transplantation, ischemia/reperfusion is known to induce tissular injury due to cell energy shortage, oxidative stress, and endoplasmic reticulum (ER) stress. ER stress stems from an accumulation of unfolded or misfolded pro…