Igor Samoylenko
YOU?
Author Swipe
View article: Comparative efficacy and safety of prolgolimab + nurulimab and nivolumab + ipilimumab in the first-line therapy of metastatic or unresectable melanoma: A systematic review and matching-adjusted indirect comparison
Comparative efficacy and safety of prolgolimab + nurulimab and nivolumab + ipilimumab in the first-line therapy of metastatic or unresectable melanoma: A systematic review and matching-adjusted indirect comparison Open
Background. Metastatic and unresectable melanoma is considered as one of the most aggressive oncological diseases with a high mortality rate. In Russia, two first line immunotherapy combinations have been approved: nivolumab plus ipilimuma…
View article: The State of Oncology Care for Melanoma Skin Cancer (C43) in Russia: One- and Five-Year Patient Survival. Localization and Histological structure (A Population-Based Study)
The State of Oncology Care for Melanoma Skin Cancer (C43) in Russia: One- and Five-Year Patient Survival. Localization and Histological structure (A Population-Based Study) Open
Введение. Показатель выживаемости больных злокачественными новообразованиями (ЗНО) наиболее точно характеризует весь комплекс проводимых противораковых мероприятий. При территориальных сравнениях чаще всего используется показатель наблюдае…
View article: Expert Consensus Statement: Sonidegib for the Treatment of Locally Advanced Basal Cell Carcinoma
Expert Consensus Statement: Sonidegib for the Treatment of Locally Advanced Basal Cell Carcinoma Open
15 мая 2025 г. состоялся экспертный совет «Возможности терапии местнораспространенного базальноклеточного рака препаратом “Сонидегиб”», по итогам которого эксперты подготовили резолюцию. В ней обозначены основные положения, касающиеся совр…
View article: Changes in clinical guidelines of 2023 and 2025 on treatment of cutaneous and mucosal melanoma
Changes in clinical guidelines of 2023 and 2025 on treatment of cutaneous and mucosal melanoma Open
The article presents a comparative analysis of Russian clinical recommendations on treatment of melanoma of the skin and mucous membranes during a period of 2020 and 2023, as well as foreign recommendations of N CCN (National Comprehensive…
View article: Rechallenge with BRAF and MEK inhibitors in the treatment of metastatic melanoma: A case report with a mini-review
Rechallenge with BRAF and MEK inhibitors in the treatment of metastatic melanoma: A case report with a mini-review Open
The management of patients with metastatic melanoma remains a difficult clinical problem. Real-world practice of treating patients with encorafenib and binimetinib after progression on combination immunotherapy and combination targeted the…
View article: Comparison of in vivo and ex vivo Elastography and Elastometric in the Diagnosis of Metastasis of Skin Melanoma to Peripheral Lymph Nodes
Comparison of in vivo and ex vivo Elastography and Elastometric in the Diagnosis of Metastasis of Skin Melanoma to Peripheral Lymph Nodes Open
Purpose : To conduct a comparative analysis of the diagnostic effectiveness of elastography and elastometry in detecting melanoma metastases in lymph nodes using histological examination of a macropreparation as a reference method. The dat…
View article: Improvement of Ultrasound Diagnosis of Regional Lymph Nodes in Skin Melanoma: Development of the Russian Classification (RUCL-M) to Reduce Hyperdiagnostics and Unjustified Biopsies.
Improvement of Ultrasound Diagnosis of Regional Lymph Nodes in Skin Melanoma: Development of the Russian Classification (RUCL-M) to Reduce Hyperdiagnostics and Unjustified Biopsies. Open
Purpose : To improve ultrasound diagnostics of regional lymph nodes in skin melanoma: to develop a new Russian ultrasound classification of regional lymph nodes in melanoma (RUCL-M) to reduce hyperdiagnosis and reduce the number of unjusti…
View article: Adjuvant Therapy and Outcomes in Patients with Stage III BRAF-Mutated Cutaneous Melanoma: Real-World Data
Adjuvant Therapy and Outcomes in Patients with Stage III BRAF-Mutated Cutaneous Melanoma: Real-World Data Open
Adjuvant therapy for BRAF-mutated stage III melanoma patients includes targeted therapy (dabrafenib + trametinib) and anti-PD-1 immunotherapy (pembrolizumab or nivolumab). Direct comparative studies are lacking, and data are limited to ret…
View article: Multiparametric Ultrasound Diagnostics in the Preoperative Assessment of Regional Lymph Nodes in Patients with High-Risk Skin Melanoma
Multiparametric Ultrasound Diagnostics in the Preoperative Assessment of Regional Lymph Nodes in Patients with High-Risk Skin Melanoma Open
The article shows the criteria for differential ultrasound diagnosis of changes in regional lymph nodes in patients with high-risk skin melanoma
View article: Analysis of electronic medical records using artificial intelligence technologies for lung cancer screening group identification: a systematic review of clinical studies
Analysis of electronic medical records using artificial intelligence technologies for lung cancer screening group identification: a systematic review of clinical studies Open
Background . Lung cancer remains one of the leading causes of mortality, with early detection significantly improving prognosis. Modern approaches require new solutions for more effective screening patient selection. Aim. To conduct a syst…
View article: Stages of training neural networks for classification and detection of skin neoplasms
Stages of training neural networks for classification and detection of skin neoplasms Open
BACKGROUND: In recent years, neural networks have become an integral part of many fields, including medicine. However, the effectiveness of these models directly depends on the quality of the training data on which they are trained. Creati…
View article: Comparative analysis of histological predictors of adverse course of anorectal melanoma and skin melanoma
Comparative analysis of histological predictors of adverse course of anorectal melanoma and skin melanoma Open
Aim. Analysis of the effect of histological characteristics on the prognosis of anorectal melanoma (ARM) and melanoma of the skin. Materials and methods. The study is based on a retrospective single-center analysis of the results of treatm…
View article: FDG-PET associations with pathological response and survival with neoadjuvant immunotherapy for melanoma
FDG-PET associations with pathological response and survival with neoadjuvant immunotherapy for melanoma Open
Background Neoadjuvant immunotherapy has become the new standard of care for stage III melanoma. This study sought to describe the metabolic changes seen with fludeoxyglucose-18-positron emission tomography (FDG-PET) following neoadjuvant …
View article: 26P Safety of the of non-viral gene therapy drug stimotimagene copolymerplasmid: Results of a multicenter phase I clinical trial
26P Safety of the of non-viral gene therapy drug stimotimagene copolymerplasmid: Results of a multicenter phase I clinical trial Open
View article: Prognostic value of gene expression profiling in melanoma: a systematic literature review
Prognostic value of gene expression profiling in melanoma: a systematic literature review Open
Introduction. Skin melanoma, despite having similar clinical and histological characteristics, can have different prognoses. Gene expression profiling potentially allows for more accurate risk stratification of patients. Aim. To study prog…
View article: Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinoma
Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinoma Open
Background CV8102, a toll-like receptor 7/8 and RIG I agonist, has demonstrated antitumor immune responses in preclinical studies. We investigated intratumoral (IT) administration of CV8102 in patients with anti-programmed cell death prote…
View article: Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers
Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers Open
The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or may develop organized lymphoid structures, where somatic hypermutation and anti…
View article: Author response: Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers
Author response: Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers Open
View article: Features of intestinal microbiota composition in cancer patients
Features of intestinal microbiota composition in cancer patients Open
Objective : to evaluate and compare the qualitative and quantitative composition of the intestinal microbiota in patients with malignant neoplasms of various localizations. Material and Methods . The study included patients who received di…
View article: Author response: Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers
Author response: Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers Open
View article: Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers
Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers Open
The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or may develop organized lymphoid structures, where somatic hypermutation and anti…
View article: Gut microbiota in patients with locally advanced cutaneous melanoma as a predictor of response to immunotherapy aPD1
Gut microbiota in patients with locally advanced cutaneous melanoma as a predictor of response to immunotherapy aPD1 Open
View article: Nutritional Composition, Fatty Acid Content, and Mineral Content of Nine Sorghum (Sorghum bicolor) Inbred Varieties
Nutritional Composition, Fatty Acid Content, and Mineral Content of Nine Sorghum (Sorghum bicolor) Inbred Varieties Open
Sorghum is a self-pollinating species belonging to the Poaceae family characterized by a resistance to drought higher than that of corn. Sorghum (Sorghum bicolor L. Moench) has been grown for centuries as a food crop in tropical areas wher…
View article: Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in the Russian Federation: results of the A1 cohort of the ISABELLA study
Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in the Russian Federation: results of the A1 cohort of the ISABELLA study Open
Background Among several treatment options for BRAF-mutant metastatic melanoma, a combination of BRAF inhibitor, MEK inhibitor, and anti-PDL1 antibody seems to be a new emergent approach recently registered in the Russian Federation. It is…
View article: Surgical treatment of distant metastases of cutaneous melanoma
Surgical treatment of distant metastases of cutaneous melanoma Open
This article addresses the issue of surgical treatment effectiveness in cases of disseminated melanoma. It is shown that disseminated melanoma can be divided into truly disseminated and oligometastatic processes, where distant metastases a…
View article: Oligometastatic skin melanoma: molecular-genetic characteristics and the effectiveness of surgical intervention
Oligometastatic skin melanoma: molecular-genetic characteristics and the effectiveness of surgical intervention Open
“Oligometastatic” represents a so-called transitional stage between localized and disseminated process. The process itself is characterized by the presence of a primary tumor and a limited number of distant solitary metastases. The disease…
View article: Treatment of Metastatic Uveal Melanoma. The Experience of a Leading Reference Center
Treatment of Metastatic Uveal Melanoma. The Experience of a Leading Reference Center Open
Uveal melanoma (UM) is the most common primary intraocular tumor. Despite successful treatment of the primary tumor, 50% of patients develop distant metastases. To date, there are no clear standards for choosing the first line of therapy f…
View article: Neoadjuvant Therapy of Resectable Skin Melanoma in Russia: the Experience of Three Cancer Centers
Neoadjuvant Therapy of Resectable Skin Melanoma in Russia: the Experience of Three Cancer Centers Open
Introduction. Neoadjuvant therapy of skin melanoma is a relatively new and dynamically developing area in the treatment of this malignant tumor. This article represents the results of an analysis of the clinical outcomes of patients receiv…
View article: Melanoma and Pregnancy. Own Clinical Experience
Melanoma and Pregnancy. Own Clinical Experience Open
The number of cases of melanoma of the skin is steadily increasing every year, which leads to an increase in cases of melanoma associated with pregnancy. To date, there is no convincing evidence of an increased risk of skin melanoma or dea…
View article: Adjuvant Targeted Therapy Versus Anti-PD-1 Immunotherapy in BRAF-Mutated Stage III Melanoma: a Real-World Data
Adjuvant Targeted Therapy Versus Anti-PD-1 Immunotherapy in BRAF-Mutated Stage III Melanoma: a Real-World Data Open
Targeted therapy and anti-PD1 immunotherapy are standard of adjuvant stage III (or equivalent stage III) melanoma treatment. Both treatments significantly improve relapse-free survival compared with placebo and ipilimumab. The impact of ad…