Ioannis Taitzoglou
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View article: Off-label use of treprostinil in adult patients in clinical cases
Off-label use of treprostinil in adult patients in clinical cases Open
Treprostinil is a relatively new tricyclic prostacyclin analog with a stable structure, extended half-life and improved potency. Currently, treprostinil is indicated by the Food and Drug Administration in the United States for the treatmen…
View article: Unraveling Cecal Alterations in <i>Clostridioides difficile</i> Colonized Mice through Comprehensive Metabolic Profiling
Unraveling Cecal Alterations in <i>Clostridioides difficile</i> Colonized Mice through Comprehensive Metabolic Profiling Open
The disruption of gut microbiota caused by antibiotics favors the intestinal colonization of Clostridioides difficile - a Gram-positive, spore-forming anaerobic bacterium that causes potentially fatal gastrointestinal infections. In an end…
View article: Synbiotics administration leads to attenuated mucosal inflammatory neutrophil infiltration and increased hematocrit in experimental ulcerative colitis
Synbiotics administration leads to attenuated mucosal inflammatory neutrophil infiltration and increased hematocrit in experimental ulcerative colitis Open
Objective:The objective of the study was to estimate the effects of synbiotics on laboratory, macroscopic, and histopathologic features in dextran sulfate sodium (DSS) experimental colitis.Materials and methods: A total of 40 Wistar rats r…
View article: Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice Open
Wine and by-products of the winemaking process, such as grape stems, are rich in bioactive polyphenolic compounds that might be beneficial for animal and human health. In recent years, the administration of dietary polyphenols with strong …
View article: Metabolic Phenotyping Study of Mouse Brain Following Microbiome Disruption by C. difficile Colonization
Metabolic Phenotyping Study of Mouse Brain Following Microbiome Disruption by C. difficile Colonization Open
Clostridioides difficile infection (CDI) is responsible for an increasing number of cases of post-antibiotic diarrhea worldwide, which has high severity and mortality among hospitalized elderly patients. The disruption of gut microbiota du…
View article: Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats
Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats Open
Life expectancy has risen in the past decades, resulting in an increase in the number of aged individuals. Exercise remains one of the most cost-effective treatments against disease and the physical consequences of aging. The purpose of th…
View article: Additional file 1 of Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats
Additional file 1 of Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats Open
Additional file 1. Altogether data for JBR.
View article: Postoperative Administration of Alpha-tocopherol Enhances Osseointegration of Stainless Steel Implants: An In Vivo Rat Model
Postoperative Administration of Alpha-tocopherol Enhances Osseointegration of Stainless Steel Implants: An In Vivo Rat Model Open
Background Alpha-tocopherol, a well-known antioxidative agent, may have a positive effect on bone formation during the remodeling phase of secondary fracture healing. Fracture healing and osseointegration of implants share common biologica…
View article: The Strong Antioxidant Sheep/Goat Whey Protein Protects Against mTOR Overactivation in Rats: A Mode of Action Mimicking Fasting
The Strong Antioxidant Sheep/Goat Whey Protein Protects Against mTOR Overactivation in Rats: A Mode of Action Mimicking Fasting Open
Whey protein, a by-product of the cheese industry, can be putatively used as a functional food due to its beneficial health properties. The main objective of the present study was to assess in vivo the effect of a sheep/goat whey protein o…
View article: Effects of sheep/goat whey protein dietary supplementation on the redox status of rats
Effects of sheep/goat whey protein dietary supplementation on the redox status of rats Open
The purpose of the present study is to estimate the effects of sheep/goat whey protein dietary supplementation on the redox status of blood and tissues of rats. Twelve male Wistar rats were divided into the control group (standard commerci…
View article: Silver Nanoparticles Alter Cell Adhesion and Proliferation of Sheep Primary Mesothelial Cells
Silver Nanoparticles Alter Cell Adhesion and Proliferation of Sheep Primary Mesothelial Cells Open
AgNPs alter the adhesive and proliferative properties of primary pleural mesothelial cells.
View article: <span>URINE AND FECES METABOLOMICS-BASED ANALYSIS OF CAROB TREATED RATS</span>
<span>URINE AND FECES METABOLOMICS-BASED ANALYSIS OF CAROB TREATED RATS</span> Open
Ceratonia siliqua L. Fabaceae, commonly known as the carob tree, is native to the eastern Mediterranean countries and its products are widely used in the diet of people living in Mediterranean Europe, Middle East and North Africa. Carobs a…
View article: Impact of Exercise and Aging on Rat Urine and Blood Metabolome. An LC-MS Based Metabolomics Longitudinal Study
Impact of Exercise and Aging on Rat Urine and Blood Metabolome. An LC-MS Based Metabolomics Longitudinal Study Open
Aging is an inevitable condition leading to health deterioration and death. Regular physical exercise can moderate the metabolic phenotype changes of aging. However, only a small number of metabolomics-based studies provide data on the eff…
View article: Protective effect of crocetin on bovine spermatozoa against oxidative stress during in vitro fertilization
Protective effect of crocetin on bovine spermatozoa against oxidative stress during in vitro fertilization Open
Summary Oxidative stress is one of the major factors that contribute to poor semen quality and low rates of in vitro fertilization. Crocetin, a main constituent of saffron ( Crocus sativus L.) possesses potent antioxidant activity, by scav…
View article: The NAD<sup>+</sup> precursor nicotinamide riboside decreases exercise performance in rats
The NAD<sup>+</sup> precursor nicotinamide riboside decreases exercise performance in rats Open
Background: Nicotinamide adenine dinucleotide (NAD+) and its phosphorylated form (NADP+) are key molecules in ubiquitous bioenergetic and cellular signaling pathways, regulating cellular metabolism and homeostasis. Thus, supplementation wi…
View article: Additional file 1: of The NAD+ precursor nicotinamide riboside decreases exercise performance in rats
Additional file 1: of The NAD+ precursor nicotinamide riboside decreases exercise performance in rats Open
Raw data of time to exhaustion in the incremental swimming test for the control and the nicotinamide riboside group. (XLSX 9Â kb)
View article: Treatment with Mesna and n‐3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats
Treatment with Mesna and n‐3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats Open
Summary Oxidative damage is a central feature of ulcerative colitis. Here, we tested whether the antioxidant Mesna, when administered alone or in combination with n‐3 polyunsaturated fatty acids (n‐3 PUFA s), affects the outcome of dextran…