Explanipedia

Stability and Processing Impacts on Faecal Microbiota Transplant Products: An Integrated Metagenomic-Culturomic Analysis Open

Calum J. Walsh, Taylor Harshegyi, Louise M. Judd, Khin Chaw, Elizabeth A. Connolly , et al. · 2025

Background Faecal microbiota transplantation (FMT) is an increasingly used microbiome-based therapy, whose clinical success depends on the stability and viability of the donor microbiota. Few studies have systematically evaluated these par…

Cross-sectional and longitudinal genotype to phenotype surveillance of SARS-CoV-2 variants over the first four years of the COVID-19 pandemic Open

Anouschka Akerman, Christina Fichter, Vanessa Milogiannakis, Camille Esneau, Mariana Ruiz Silva , et al. · 2024

Improved efficiency using sequential automated immunoassays for syphilis screening in blood donors Open

Anthea Cheng, Anindita Das, Claire E. Styles, Zin Naing, William D. Rawlinson , et al. · 2024

Using sequential immunoassays for the screening of blood donors is well described for viral serology testing but not for the screening of syphilis. In this study, we report the evaluation results and 2-year sequential testing data using tw…

New tatt? We're ok with that! Relaxing the tattoo deferral for plasmapheresis donors maintains safety and increases donations Open

Claire E. Styles, Veronica C. Hoad, Robert Harley, John Kaldor, Iain B. Gosbell · 2024

Background and Objectives Tattooing is one of the leading donor deferral reasons in Australia. Until September 2020, donors were deferred from all donation types for 4 months after a tattoo. At this time, our guideline changed such that do…

Cross-sectional and longitudinal genotype to phenotype surveillance of SARS-CoV-2 variants over the first four years of the COVID-19 pandemic Open

Anna‐Karin Åkerman, Christina Fichter, Vanessa Milogiannakis, Camille Esneau, MR Silva , et al. · 2024

Background Continued phenotyping and ongoing surveillance are important in current and future monitoring of emerging SARS-CoV-2 lineages. Herein we developed pragmatic strategies to track the emergence, spread and phenotype of SARS-CoV-2 v…

Compliance with Australian Orthopaedic Association guidelines does not reduce the risk of venous thromboembolism after total hip and knee arthroplasty Open

Helen Badge, Tim Churches, Justine Naylor, Wei Xuan, Elizabeth Armstrong , et al. · 2024

Has the frequency of ABO RhD blood groups in Australian blood donors changed as a result of the removal of the variant Creutzfeldt–Jakob disease‐based deferral? Open

Rena Hirani, Veronica C. Hoad, Iain B. Gosbell, David O. Irving · 2024

Background and Objectives Until 25 July 2022, Australians who had spent more than 6 months in the United Kingdom or territories between 1980 and 1996 were deferred from blood donation due to the risk of variant Creutzfeldt–Jakob disease. R…

Seroprevalence of Japanese encephalitis virus-specific antibodies in Australia following novel epidemic spread: protocol for a national cross-sectional study Open

Noni Winkler, Archana Koirala, Guddu Kaur, S. R. Prasad, Rena Hirani , et al. · 2024

Introduction Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes encephalitis and other morbidity in Southeast Asia. Since February 2022, geographically dispersed JEV human, animal and vector detections occurred on…

International Forum on Management of Blood Donors with Culture‐Positive Platelet Donations: Summary Open

Ralph R. Vassallo, Hany Kamel, Ruchika Goel, Arwa Z. Al‐Riyami, Zakariya Al Muharrmi , et al. · 2023

Safety Analysis of Extended Platelet Shelf-Life with Large-Volume Delayed Sampling on BACT/ALERT® VIRTUO® in Australia Open

Anthea Cheng, Anindita Das, Khin Chaw, Peta M. Dennington, Claire E. Styles , et al. · 2023

Transfusion-transmitted bacterial infection (TTBI) is the leading cause of transfusion-transmitted infections. Platelet components are more likely to be associated with bacterial contamination due to their storage requirements. Australian …

Removal of UK‐donor deferral for variant Creutzfeldt–Jakob disease: A large donation gain in Australia Open

Veronica C. Hoad, Clive R. Seed, Philip Kiely, Claire E. Styles, Hamish McManus , et al. · 2023

Background and Objectives Until 25 July 2022, people who spent more than 6 months in the United Kingdom during the variant Creutzfeldt–Jakob disease (vCJD) risk period 1980–1996 (UK donors) were deferred from blood donation in Australia. R…

An Australian perspective on monkeypox virus and stool transplants Open

Bryant Koh, Anthea Cheng, Khin Chaw, Iain B. Gosbell · 2022

Association between VTE and antibiotic prophylaxis guideline compliance and patient-reported outcomes after total hip and knee arthroplasty: an observational study Open

Helen Badge, Tim Churches, Justine Naylor, Wei Xuan, Elizabeth Armstrong , et al. · 2022

An Outbreak of Japanese Encephalitis Virus in Australia; What Is the Risk to Blood Safety? Open

Veronica C. Hoad, Philip Kiely, Clive R. Seed, Elvina Viennet, Iain B. Gosbell · 2022

A widespread outbreak of Japanese encephalitis virus (JEV) was detected in mainland Australia in 2022 in a previous non-endemic area. Given JEV is known to be transfusion-transmissible, a rapid blood-safety risk assessment was performed us…

Investigation for bacterial contamination of blood products implicated in suspected transfusion-transmitted bacterial infection Open

Vanessa Clifford, Gena Gonis, Gemma Crighton, Helen Savoia, Iain B. Gosbell , et al. · 2022

Serological testing of blood donors to characterise the impact of COVID-19 in Melbourne, Australia, 2020 Open

Dorothy A. Machalek, Kaitlyn Vette, Marnie Downes, John B. Carlin, Suellen Nicholson , et al. · 2022

Rapidly identifying and isolating people with acute SARS-CoV-2 infection has been a core strategy to contain COVID-19 in Australia, but a proportion of infections go undetected. We estimated SARS-CoV-2 specific antibody prevalence (seropre…

Risk of variant Creutzfeldt–Jakob disease transmission by blood transfusion in Australia Open

Hamish McManus, Clive R. Seed, Veronica C. Hoad, Philip Kiely, John Kaldor , et al. · 2022

Background and Objectives Most of the 233 worldwide cases of variant Creutzfeldt–Jakob disease (vCJD) have been reported in the United Kingdom and 3 have been associated with transfusion‐transmission. To mitigate the potential vCJD risk to…

Compliance with Australian Orthopaedic Association guidelines does not reduce the risk of venous thromboembolism after total hip and knee joint arthroplasty: an observational study Open

Helen Badge, Tim Churches, Justine Naylor, Wei Xuan, Elizabeth Armstrong , et al. · 2022

Background Preventing avoidable venous-thrombo-embolism (VTE) is a priority to improve patient and service outcomes after total hip and total knee arthroplasty (THA, TKA), but compliance with relevant clinical guidelines varies. This study…

SEROLOGICAL TESTING OF BLOOD DONORS TO CHARACTERISE THE IMPACT OF COVID-19 IN MELBOURNE, AUSTRALIA, 2020 Open

Dorothy A. Machalek, Kaitlyn Vette, Marnie Downes, John B. Carlin, Suellen Nicholson , et al. · 2022

Rapidly identifying and isolating people with acute SARS-CoV-2 infection has been a core strategy to contain COVID-19 in Australia, but a proportion of infections go undetected. We estimated SARS-CoV-2 specific antibody prevalence (seropre…

Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Australia After the First Epidemic Wave in 2020: A National Survey Open

Kaitlyn Vette, Dorothy A. Machalek, Heather F. Gidding, Suellen Nicholson, Matthew O’Sullivan , et al. · 2022

Background As of mid-2021, Australia’s only nationwide coronavirus disease 2019 (COVID-19) epidemic occurred in the first 6 months of the pandemic. Subsequently, there has been limited transmission in most states and territories. Understan…

Severe Acute Respiratory Syndrome Coronavirus 2 and Blood Safety: An Updated Review Open

Philip Kiely, Veronica C. Hoad, Clive R. Seed, Iain B. Gosbell · 2022

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus first identified in late 2019 and subsequently declared a worldwide pandemic in March 2020. In this review, we provide an o…

Non-compliance with clinical guidelines increases the risk of complications after primary total hip and knee joint replacement surgery Open

Helen Badge, Tim Churches, Justine Naylor, Wei Xuan, Elizabeth Armstrong , et al. · 2021

Background Total hip and total knee replacement (THR/TKR) are common and effective surgeries to reduce the pain and disability associated with arthritis but are associated with small but significant risks of preventable complications such …

Serological testing of blood donors to characterise the impact of COVID-19 in Melbourne, 2020 Open

Dorothy A. Machalek, Kaitlyn Vette, Marnie Downes, John B. Carlin, Suellen Nicholson , et al. · 2021

Results of population-based age-stratified seroepidemiological investigation in Melbourne, Australia.

Serological testing of blood donors to characterise the impact of COVID-19 in Melbourne, 2020 Open

Dorothy A. Machalek, Kaitlyn Vette, Marnie Downes, John B. Carlin, Suellen Nicholson , et al. · 2021

Results of population-based age-stratified seroepidemiological investigation in Melbourne, Australia.

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants Open

Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, D.R. Darley, Deepti Pilli , et al. · 2021

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthr…

SARS Coronavirus-2 Microneutralisation and Commercial Serological Assays Correlated Closely for Some but Not All Enzyme Immunoassays Open

Gregory J. Walker, Zin Naing, Alberto Ospina Stella, Malinna Yeang, Joanna Caguicla , et al. · 2021

Serological testing for SARS-CoV-2-specific antibodies provides important research and diagnostic information relating to COVID-19 prevalence, incidence and host immune response. A greater understanding of the relationship between function…

Seroprevalence of SARS‐CoV‐2‐specific antibodies in Sydney after the first epidemic wave of 2020 Open

Heather F. Gidding, Dorothy A. Machalek, Alexandra Hendry, Helen Quinn, Kaitlyn Vette , et al. · 2021

Estimated SARS-CoV-2 seroprevalence was below 1%, indicating that community transmission was low during the first COVID-19 epidemic wave in Sydney. These findings suggest that early control of the spread of COVID-19 was successful, but eff…

Motivators of and barriers to becoming a COVID‐19 convalescent plasma donor: A survey study Open

Barbara Masser, Eamonn Ferguson, Rachel Thorpe, Claire Lawrence, Tanya E. Davison , et al. · 2020

Objectives To determine the motivators and barriers to COVID‐19 convalescent plasma donation by those in the United Kingdom who have been diagnosed with or who have had symptoms of SARS‐CoV‐2 (COVID‐19) but who have not donated. Background…

SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants Open

Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, D.R. Darley, Deepti Pilli , et al. · 2020

The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious …

What are Optimal Bacteriological Screening Test Cut-Offs for Pasteurized Donor Human Milk Intended for Feeding Preterm Infants? Open

Vanessa Clifford, Laura D. Klein, Christine Sulfaro, Tass Karalis, Veronica C. Hoad , et al. · 2020

Background Definitive criteria for microbial screening of pasteurized donor human milk are not well established and international recommendations vary. Aims (1) To review pasteurized donor human milk batch discard due to failed microbial s…

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