Iain W. Chalmers
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View article: Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection Open
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes Open
Background: Schistosoma mansoni, a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigene…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures Open
Extended data This project contains the following extended data: - Fig S1. Dose response titrations of compounds 15, 16, 33, 35 and 36 against schistosomula. - Fig S2. Compound 33 treatment induces the rel…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures Open
Extended data This project contains the following extended data: - Fig S1. Dose response titrations of compounds 15, 16, 33, 35 and 36 against schistosomula. - Fig S2. Compound 33 treatment induces the rel…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures Open
Extended data This project contains the following extended data: - Fig S1. Dose response titrations of compounds 15, 16, 33, 35 and 36 against schistosomula. - Fig S2. Compound 33 treatment induces the rel…
View article: Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility
Special considerations for studies of extracellular vesicles from parasitic helminths: A community‐led roadmap to increase rigour and reproducibility Open
Over the last decade, research interest in defining how extracellular vesicles (EVs) shape cross‐species communication has grown rapidly. Parasitic helminths, worm species found in the phyla Nematoda and Platyhelminthes, are well‐recognise…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures Open
Extended data This project contains the following extended data: - Fig S1. Dose response titrations of compounds 15, 16, 33, 35 and 36 against schistosomula. - Fig S2. Compound 33 treatment induces the rel…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures Open
Extended data This project contains the following extended data: - Fig S1. Dose response titrations of compounds 15, 16, 33, 35 and 36 against schistosomula. - Fig S2. Compound 33 treatment induces the rel…
View article: Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary tables and movies
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary tables and movies Open
Extended data This project contains the following extended data: Table S1. Chemical structures of the 39 compounds included in this study. Table S2. Z´ values for both phenotype and motility of the Robowo…
View article: Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in<i>Schistosoma haematobium</i>and<i>Schistosoma mansoni</i>infection
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in<i>Schistosoma haematobium</i>and<i>Schistosoma mansoni</i>infection Open
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S…
View article: Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production Open
α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. Mutations in the human genes encoding ei…
View article: Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae Open
Extracellular Vesicles (EVs) are an integral component of cellular/organismal communication and have been found in the excreted/secreted (ES) products of both protozoan and metazoan parasites. Within the blood fluke schistosomes, EVs have …
View article: <i>In silico</i> characterisation of the complete Ly6 protein family in <i>Fasciola gigantica</i> supported through transcriptomics of the newly-excysted juveniles
<i>In silico</i> characterisation of the complete Ly6 protein family in <i>Fasciola gigantica</i> supported through transcriptomics of the newly-excysted juveniles Open
Incorporating the recently available F. gigantica genome, the current work revealed 20 novel Ly6 family members in F. gigantica and, in parallel, significantly extended the F. hepatica complement from 3 to 18 members.
View article: Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation Open
Schistosomiasis is a neglected disease of poverty that is caused by infection with blood fluke species contained within the genus Schistosoma. For the last 40 years, control of schistosomiasis in endemic regions has predominantly been faci…
View article: <i>Schistosoma mansoni</i> α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
<i>Schistosoma mansoni</i> α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production Open
α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. Mutations in the human genes encoding ei…
View article: Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function
Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function Open
View article: Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities Open
Background: Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease of considerable importance in resource-poor communities throughout the developing world. In the absence of an immunoprophylacti…
View article: <i>Schistosoma mansoni</i>lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation
<i>Schistosoma mansoni</i>lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation Open
Schistosomiasis is a chronically-debilitating neglected tropical disease (NTD) that predominantly affects people living in resource-poor communities of tropical and subtropical countries. Schistosoma mansoni , one of three species responsi…
View article: Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities Open
Background: Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease of considerable importance in resource-poor communities throughout the developing world. In the absence of an immunoprophylacti…
View article: Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Extended data
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Extended data Open
Extended dataThis project contains the following extended data:• Supplementary Table 1 (List of putative SmMLL-1 inhibitors (first set) identified by structure-based virtual screening)• Supplementary Table 2 (Phenotype and motility Z´ valu…
View article: Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities Open
This data record consists of nine datasets. Dataset 1. RNAi-mediated knockdown of smp_138030/smmll-1.xlsxDataset 2. Schistosomula drug screen of putative SmMLL-1 inhibitors.xlsxDataset 3. Adult worm drug screen of putative SmMLL-1 inhibito…
View article: Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities Open
Extended dataThis project contains the following extended data:• Supplementary Table 1 (List of putative SmMLL-1 inhibitors (first set) identified by structure-based virtual screening)• Supplementary Table 2 (Phenotype and motility Z´ valu…
View article: Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Underlying data
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Underlying data Open
Underlying dataThis data record consists of nine datasets. Dataset 1. RNAi-mediated knockdown of smp_138030/smmll-1.xlsxDataset 2. Schistosomula drug screen of putative SmMLL-1 inhibitors.xlsxDataset 3. Adult worm drug screen of putative S…
View article: The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets Open
Collectively, these results provide further support for the development of next-generation drugs targeting schistosome epigenetic pathway components. In particular, the progression of histone methylation/demethylation modulators presents a…
View article: The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets Open
Background Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability to ki…
View article: Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs Drug Resist. 8 (2018) 559–570]
Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs Drug Resist. 8 (2018) 559–570] Open
View article: Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity
Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity Open
View article: Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni
Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni Open
View article: Antibody responses to <i>Schistosoma mansoni</i> schistosomula antigens
Antibody responses to <i>Schistosoma mansoni</i> schistosomula antigens Open
Summary While antigens from Schistosoma schistosomula have been suggested as potential vaccine candidates, the association between antibody responses with schistosomula antigens and infection intensity at reinfection is not well known. Sch…
View article: <i>Schistosoma mansoni</i> schistosomula antigens induce Th1/Pro‐inflammatory cytokine responses
<i>Schistosoma mansoni</i> schistosomula antigens induce Th1/Pro‐inflammatory cytokine responses Open
Summary Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets, although cellular immune responses against schistosomula antigens in endemic human populations a…