Explanipedia

IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19 Open

Arturo Pérez‐Vázquez, Agnieszka Skowyra, Tadhg Crowley, Janaki Velmurugan, Ciaran M. Lee , et al. · 2025

SUMMARY IFN-γ is secreted by multiple lymphoid subsets in response to antigen stimulation and can reprogram and prime macrophages epigenetically and transcriptionally to increase responses to inflammatory stimuli such as LPS, IL-1β or TNF-…

Dynamics of the gut microbiome in individuals at risk of rheumatoid arthritis: a cross-sectional and longitudinal observational study Open

Christopher Rooney, Ian B. Jeffery, Kulveer Mankia, Mark H. Wilcox, Paul Emery · 2024

These data suggest conflicting reports on Prevotellaceae overabundance are likely due to sampling within a heterogeneous population along a dynamic disease spectrum, with certain Prevotellaceae strains/clades possibly contributing to the e…

Editorial: bacterial gut symbionts as live biotherapeutic agents in <span>IBS</span>—a rosy future despite potential long‐term safety concerns. Authorsʼ reply Open

Eamonn M.M. Quigley, Alex Stevenson, Ian B. Jeffery, Jacob Masters · 2023

LINKED CONTENT This article is linked to Quigley et al papers. To view these articles, visit https://doi.org/10.1111/apt.17310 and https://doi.org/10.1111/apt.17332

627 Oral administration of MRx0518 in treatment-naïve cancer patients is associated with compositional taxonomic and metabolomic changes indicative of anti-tumorigenic efficacy Open

Mark P. Lythgoe, Benjamin H. Mullish, Adam E. Frampton, Paola Dama, Emily Pickford , et al. · 2022

Background Live biotherapeutic products (LBPs) are promising novel anti-cancer therapies. Their mechanism of action has not yet been fully elucidated but is thought to be partly due to compositional changes in the gut microbiome and metabo…

The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism Open

Paromita Sen, Eoin Sherwin, Kiran Sandhu, Thomaz F. S. Bastiaanssen, Gerard M. Moloney , et al. · 2022

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by deficits in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms. The aetiology of ASD is complex and involves an interplay…

Collateral Damage in the Human Gut Microbiome - Blastocystis Is Significantly Less Prevalent in an Antibiotic-Treated Adult Population Compared to Non-Antibiotic Treated Controls Open

Ian B. Jeffery, Paul D. Cotter, Pauline D. Scanlan · 2022

Antibiotics can drive the rapid loss of non-target, phylogenetically diverse microorganisms that inhabit the human gut. This so-called “collateral damage” has myriad consequences for host health and antibiotic mediated changes to the gut m…

The fecal mycobiome in patients with Irritable Bowel Syndrome Open

Anubhav Das, Eileen O’Herlihy, Fergus Shanahan, Paul W. O’Toole, Ian B. Jeffery · 2021

The gut virome in Irritable Bowel Syndrome differs from that of controls Open

Simone Coughlan, Anubhav Das, Eileen O’Herlihy, Fergus Shanahan, Paul W. O’Toole , et al. · 2021

Irritable Bowel Syndrome (IBS), the most common gastrointestinal disorder, is diagnosed solely on symptoms. Potentially diagnostic alterations in the bacterial component of the gut microbiome (the bacteriome) are associated with IBS, but d…

A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn's Disease Open

Richard Hansen, Ian R. Sanderson, Rafeeq Muhammed, Stephen Allen, Christos Tzivinikos , et al. · 2020

INTRODUCTION: Thetanix (gastroresistant capsules containing lyophilized Bacteroides thetaiotaomicron ) is a live biotherapeutic, under development for Crohn's disease, that antagonizes transcription factor nuclear factor kappa B, reducing …

Adjusting for age improves identification of gut microbiome alterations in multiple diseases Open

Tarini Shankar Ghosh, Mrinmoy Das, Ian B. Jeffery, Paul W. O’Toole · 2020

Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset consti…

IPCO: Inference of Pathways from Co-variance analysis Open

Mrinmoy Das, Tarini Shankar Ghosh, Ian B. Jeffery · 2020

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries Open

Tarini Shankar Ghosh, Simone Rampelli, Ian B. Jeffery, Aurelia Santoro, Marta C. Neto , et al. · 2020

Objective Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterations in the gut microbiota in a manner ac…

Author response: Adjusting for age improves identification of gut microbiome alterations in multiple diseases Open

Tarini Shankar Ghosh, Mrinmoy Das, Ian B. Jeffery, Paul W. O’Toole · 2019

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Interaction between disease-m…

Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults Open

A. McCann, Ian B. Jeffery, Bouchra Ouliass, Guylaine Ferland, Xueyen Fu , et al. · 2019

Gut microbiota alterations associated with reduced bone mineral density in older adults Open

Mrinmoy Das, Owen Cronin, David M. Keohane, Edel M Cormac, Helena Nugent , et al. · 2019

Objective To investigate compositional differences in the gut microbiota associated with bone homeostasis and fractures in a cohort of older adults. Methods Faecal microbiota profiles were determined from 181 individuals with osteopenia (n…

IPCO: Inference of Pathways from Co-variance analysis Open

Mrinmoy Das, Tarini Shankar Ghosh, Ian B. Jeffery · 2019

Key aspects of microbiome research are accurate identification of taxa followed by the profiling of their functionality. Amplicon profiling based on the 16S ribosomal DNA sequence is a ubiquitous technique to identify and profile the abund…

Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis Open

Achilleas Floudas, Gabriella Aviello, Christian Schwartz, Ian B. Jeffery, Paul W. O’Toole , et al. · 2019

Infection with parasite helminths induces potent modulation of the immune system of the host. Epidemiological and animal studies have shown that helminth infections can suppress or exacerbate unrelated autoimmune, allergic, and other infla…

Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity Open

Tam T. T. Tran, Fabien Cousin, Denise B. Lynch, Ravi S. Menon, Jennifer M. Brulc , et al. · 2019

Additional file 3: of Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity Open

Tam T. T. Tran, Fabien Cousin, Denise B. Lynch, Ravi S. Menon, Jennifer M. Brulc , et al. · 2019

Supplementary Tables S5–S8. (XLSX 51 kb)

Publisher Correction: Enterotypes in the landscape of gut microbial community composition Open

Paul Igor Costea, Falk Hildebrand, Manimozhiyan Arumugam, Fredrik Bäckhed, Martin J. Blaser , et al. · 2018

Enterotypes in the landscape of gut microbial community composition Open

Paul Igor Costea, Falk Hildebrand, Manimozhiyan Arumugam, Fredrik Bäckhed, Martin J. Blaser , et al. · 2017

The oral microbiota in colorectal cancer is distinctive and predictive Open

Burkhardt Flemer, Ryan D. Warren, Maurice Barrett, Katryna Cisek, Anubhav Das , et al. · 2017

Background and aims Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally deri…

Microbiome–health interactions in older people Open

Paul W. O’Toole, Ian B. Jeffery · 2017

MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells Open

Gomaa Sulaiman, Aoife A. Cooke, Brendan Ffrench, Claudia Gasch, Olayemi Azeez Abdullai , et al. · 2017

Erratum to: Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort Open

Cian J. Hill, Denise B. Lynch, Kiera Murphy, Marynka Ulaszewska, Ian B. Jeffery , et al. · 2017

Erratum: Following publication of this article, it has come to our attention that the name of the author Kieran Tuohy’s name was captured incorrectly as “Touhy” and instead should be Kieran Tuohy.

Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort Open

Cian J. Hill, Denise B. Lynch, Kiera Murphy, Marynka Ulaszewska, Ian B. Jeffery , et al. · 2017

Additional file 1: Table S1. of Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort Open

Cian J. Hill, Denise B. Lynch, Kiera Murphy, Marynka Ulaszewska, Ian B. Jeffery , et al. · 2017

Metadata collected from the Infantmet cohort. Blank space in the metadata table indicates that information on that particular factor was not received for that infant (or mother). Table S2. Preterm infant details and clinical metadata, incl…

Effect of room temperature transport vials on DNA quality and phylogenetic composition of faecal microbiota of elderly adults and infants Open

Cian J. Hill, Jillian R. Brown, Denise B. Lynch, Ian B. Jeffery, C. Anthony Ryan , et al. · 2016

The commercial storage vials appear to be suitable for high diversity microbiota samples, but may be less appropriate for lower diversity samples. Differences between fresh and stored samples mean that where storage is unavoidable, a consi…

Tumour-associated and non-tumour-associated microbiota in colorectal cancer Open

Burkhardt Flemer, Denise B. Lynch, Jillian M R Brown, Ian B. Jeffery, Feargal J. Ryan , et al. · 2016

Objective: A signature that unifies the colorectal cancer (CRC) microbiota across multiple studies has not been identified. In addition to methodological variance, heterogeneity may be caused by both microbial and host response differences…

Erratum to: signatures of early frailty in the gut microbiota Open

Matthew Jackson, Ian B. Jeffery, Michelle Beaumont, Jordana T. Bell, Andrew G. Clark , et al. · 2016

Ian B. Jeffery YOU? Author Swipe