Benjamin I. Perry
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View article: Testing the Transportability of the Psychosis Metabolic Risk Calculator in Canada (Quebec): International External Validation Study
Testing the Transportability of the Psychosis Metabolic Risk Calculator in Canada (Quebec): International External Validation Study Open
Background and Hypothesis Cardiometabolic morbidity largely explains premature mortality in people with psychotic disorders and is detectable from psychosis onset. Currently, no accurate cardiometabolic risk prediction tool exists for youn…
View article: Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study
Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study Open
Schizophrenia (SZ) is accompanied by structural brain alterations and elevated cardiometabolic risk, potentially linked through shared immune–metabolic mechanisms. To test for shared genetic underpinnings, we performed multi-trait colocali…
View article: A problem at the heart of precision medicine – are current clinical prediction models fully actionable for individuals?
A problem at the heart of precision medicine – are current clinical prediction models fully actionable for individuals? Open
Current clinical prediction models are static models of association, rather than correctly specified counterfactual prediction models based on modifiable causes. They do not tell us that, if we change a predictor variable, this will alter …
View article: The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis
The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis Open
Background and Hypothesis The extent to which tapering antipsychotic (AP) attenuates AP-related movement disorders and cardiometabolic dysfunction remains unclear. We aim to investigate the long-term effects of AP-dose reduction on these a…
View article: Antipsychotic-induced weight gain in psychosis – a causal mediation analysis and feasibility study of casual actionable prediction model development using counterfactuals to target obesity
Antipsychotic-induced weight gain in psychosis – a causal mediation analysis and feasibility study of casual actionable prediction model development using counterfactuals to target obesity Open
Background: People with psychosis have a reduced life expectancy by 15 years, mainly due to preventable physical illnesses for which obesity is a precursor. Obesity is three times more common in psychosis and antipsychotics are an importan…
View article: Antipsychotic-induced weight gain in psychosis – a causal mediation analysis and feasibility study of casual actionable prediction model development using counterfactuals to target obesity
Antipsychotic-induced weight gain in psychosis – a causal mediation analysis and feasibility study of casual actionable prediction model development using counterfactuals to target obesity Open
Background: People with psychosis have a reduced life expectancy by 15 years, mainly due to preventable physical illnesses for which obesity is a precursor. Obesity is three times more common in psychosis and antipsychotics are an importan…
View article: Antipsychotic-induced weight gain in psychosis – a causal mediation analysis and feasibility study of casual actionable prediction model development using counterfactuals to target obesity
Antipsychotic-induced weight gain in psychosis – a causal mediation analysis and feasibility study of casual actionable prediction model development using counterfactuals to target obesity Open
Background: People with psychosis have a reduced life expectancy by 15 years, mainly due to preventable physical illnesses for which obesity is a precursor. Obesity is three times more common in psychosis and antipsychotics are an importan…
View article: People with severe mental illness are not adequately screened for non-communicable diseases: Findings of a multi-country cross-sectional study in South Asia
People with severe mental illness are not adequately screened for non-communicable diseases: Findings of a multi-country cross-sectional study in South Asia Open
Introduction People with severe mental illness die 10-20 years earlier than the general population. This is largely due to non-communicable diseases (NCDs) such as hypertension, diabetes and hypercholesterolaemia increasing the risk of car…
View article: Clinical management of self-harming children and adolescents in the United Kingdom: a multicentre audit
Clinical management of self-harming children and adolescents in the United Kingdom: a multicentre audit Open
Introduction The risk of self-harm is highest in younger age groups, with increasing numbers of under-18s being admitted to hospital due to self-harm in recent years in the UK1,2. The National Institute for Health and Care Excellence (NICE…
View article: A problem at the heart of precision medicine – are current clinical prediction models fully actionable for individuals?
A problem at the heart of precision medicine – are current clinical prediction models fully actionable for individuals? Open
Current clinical prediction models are static models of association, rather than correctly specified counterfactual prediction models based on modifiable causes. They do not tell us that, if we change a predictor variable, this will alter …
View article: Severe Mental Illness as a Multisystem Metabolic Disorder From Brain to Body and Back Again
Severe Mental Illness as a Multisystem Metabolic Disorder From Brain to Body and Back Again Open
View article: Structure–activity relationships of fenarimol analogues with potent <i>in vitro</i> and <i>in vivo</i> activity against <i>Madurella mycetomatis</i> , the main causative agent of mycetoma
Structure–activity relationships of fenarimol analogues with potent <i>in vitro</i> and <i>in vivo</i> activity against <i>Madurella mycetomatis</i> , the main causative agent of mycetoma Open
From 185 fenarimol analogues evaluated against M. mycetomatis , 22 were found to be potent in vitro , with 5 showing promise in an in vivo model; low predicted log D (<2.5) correlated with better in vivo efficacy, providing insights for fu…
View article: Metabolism across the Lifespan Implications for Body and Mind
Metabolism across the Lifespan Implications for Body and Mind Open
View article: Psychosis metabolic risk calculator ( <scp>PsyMetRiC</scp> ) in early psychosis: External validation study in <scp>Finland</scp>
Psychosis metabolic risk calculator ( <span>PsyMetRiC</span> ) in early psychosis: External validation study in <span>Finland</span> Open
Introduction Accurate detection of cardiometabolic risk in early psychosis is crucial to reducing somatic morbidity and mortality in people with psychotic disorders. We conducted an external validation of the psychosis metabolic risk calcu…
View article: Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood
Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood Open
Importance Research suggests that low-grade, nonresolving inflammation may predate adult mental and physical illness. However, evidence to date is largely cross-sectional or focuses on single disorder outcomes. Objectives To examine trajec…
View article: Metabolic syndrome risk prediction in an Australian sample with first-episode psychosis using the psychosis metabolic risk calculator: A validation study
Metabolic syndrome risk prediction in an Australian sample with first-episode psychosis using the psychosis metabolic risk calculator: A validation study Open
Objective To examine the accuracy and likely clinical usefulness of the Psychosis Metabolic Risk Calculator (PsyMetRiC) in predicting up-to six-year risk of incident metabolic syndrome in an Australian sample of young people with first-epi…
View article: Longitudinal Trajectories of Plasma Polyunsaturated Fatty Acids and Associations With Psychosis-Spectrum Outcomes in Early Adulthood
Longitudinal Trajectories of Plasma Polyunsaturated Fatty Acids and Associations With Psychosis-Spectrum Outcomes in Early Adulthood Open
Aims Evidence supports associations between polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and psychosis risk. However, longitudinal PUFA trajectories in the general population have not been characterised. The aims …
View article: Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up study
Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up study Open
View article: Associations of 2,922 genetically predicted plasma protein levels with mental illness and response to treatment
Associations of 2,922 genetically predicted plasma protein levels with mental illness and response to treatment Open
There is growing evidence that mental disorders are associated with altered levels of plasma proteins, potentially indicating molecular targets for drug development or repurposing, but determining which associations are due to confounding …
View article: Longitudinal Trajectories of Plasma Polyunsaturated Fatty Acids and Associations With Psychosis Spectrum Outcomes in Early Adulthood
Longitudinal Trajectories of Plasma Polyunsaturated Fatty Acids and Associations With Psychosis Spectrum Outcomes in Early Adulthood Open
Optimization of polyunsaturated fatty acid status during development warrants further investigation in relation to psychotic symptoms in early adulthood.
View article: Using Electronic Health Records to Facilitate Precision Psychiatry
Using Electronic Health Records to Facilitate Precision Psychiatry Open
The use of clinical prediction models to produce individualized risk estimates can facilitate the implementation of precision psychiatry. As a source of data from large, clinically representative patient samples, electronic health records …
View article: Plasma protein levels and psychiatric outcomes
Plasma protein levels and psychiatric outcomes Open
View article: Persistent Childhood Anxiety And Inflammation And Associations With Adult Mental And Cardiometabolic Health Disorders: Results From Two Longitudinal Cohort Studies.
Persistent Childhood Anxiety And Inflammation And Associations With Adult Mental And Cardiometabolic Health Disorders: Results From Two Longitudinal Cohort Studies. Open
View article: Lester positive cardiometabolic resource update: improving cardiometabolic outcomes in people with severe mental illness
Lester positive cardiometabolic resource update: improving cardiometabolic outcomes in people with severe mental illness Open
View article: OC 01.1 Discordance between Computed Tomography Pulmonary Angiography (CTPA) and Transthoracic Echocardiography (TTE) in Identification of Right Ventricular Strain in Patients with Acute Pulmonary Embolism
OC 01.1 Discordance between Computed Tomography Pulmonary Angiography (CTPA) and Transthoracic Echocardiography (TTE) in Identification of Right Ventricular Strain in Patients with Acute Pulmonary Embolism Open
View article: Schizophrenia and cardiometabolic abnormalities: A Mendelian randomization study
Schizophrenia and cardiometabolic abnormalities: A Mendelian randomization study Open
Background: Individuals with a diagnosis of schizophrenia are known to be at high risk of premature mortality due to poor physical health, especially cardiovascular disease, diabetes, and obesity. The reasons for these physical health outc…
View article: More must be done to reduce cardiovascular risk for patients on antipsychotic medications
More must be done to reduce cardiovascular risk for patients on antipsychotic medications Open
aImperial College London, Institute of Clinical Sciences and UKRI, MRC London Institute of Medical Sciences, Hammersmith Campus, London bDepartment of Psychiatry, University of Cambridge cCambridgeshire and Peterborough NHS Foundation Trus…
View article: Predicting treatment resistance from first-episode psychosis using routinely collected clinical information
Predicting treatment resistance from first-episode psychosis using routinely collected clinical information Open
View article: The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples
The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples Open
View article: Predicting treatment resistance in people with a first-episode of psychosis using commonly recorded clinical information
Predicting treatment resistance in people with a first-episode of psychosis using commonly recorded clinical information Open
Introduction 23% of people experiencing a first episode of psychosis (FEP) develop treatment resistant schizophrenia (TRS). At present, there are no established methods to accurately identify who will develop TRS from baseline. Objectives …