Ian B. Wilkinson
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View article: Micromechanical heterogeneity in abdominal aortic aneurysms is associated with rupture risk
Micromechanical heterogeneity in abdominal aortic aneurysms is associated with rupture risk Open
Abdominal aortic aneurysms (AAA) are common, especially in men, and associated with a high mortality when ruptured. Clinical guidance for surgical repair is based on the maximum aortic diameter (>5.5 cm in men or 5 cm in women) but this is…
View article: A pragmatic, randomised, open-label, multi-centre UK registry-facilitated trial evaluating the effect of high-dose cholecalciferol on mortality in patients on dialysis: the SIMPLIFIED trial
A pragmatic, randomised, open-label, multi-centre UK registry-facilitated trial evaluating the effect of high-dose cholecalciferol on mortality in patients on dialysis: the SIMPLIFIED trial Open
Background Vitamin D deficiency is common in patients with end stage kidney disease (ESKD) and is a strong predictor of death from cardiovascular disease, infections and cancer. Currently only 68% of patients in the UK survive 3 years or m…
View article: Ethnic differences in plasma aldosterone concentration and regulatory mechanisms of aldosterone: protocol for a systematic review and meta-analysis
Ethnic differences in plasma aldosterone concentration and regulatory mechanisms of aldosterone: protocol for a systematic review and meta-analysis Open
Introduction Black ethnic cohorts, when compared with white cohorts, have disproportionately higher rates of essential hypertension and related complications. Ethnic differences in the renin-angiotensin-aldosterone system have been identif…
View article: An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects
An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects Open
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied…
View article: Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide
Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide Open
PROSPERO identifier no. CRD420251003142.
View article: Phenotypes of Hypertension: Impact of Age and Sex on Hemodynamic Mechanisms
Phenotypes of Hypertension: Impact of Age and Sex on Hemodynamic Mechanisms Open
Background Essential hypertension is often treated as a uniform condition. However, it encompasses distinct patterns of blood pressure elevation such as isolated systolic, systolic diastolic, and isolated diastolic hypertension, which vary…
View article: Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets
Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets Open
In this position statement the British and Irish Hypertension Society (BIHS) present a review of the current evidence for blood pressure (BP) treatment thresholds and targets. The BIHS recommend initiating pharmacological antihypertensive …
View article: Corrigendum to ‘Persistent hypertension at 3 months postpartum among women with hypertensive disorders of pregnancy at a tertiary hospital in Southwestern Uganda’ [AJOG Global Reports Volume 3, Issue 1, February 2023, 100163]
Corrigendum to ‘Persistent hypertension at 3 months postpartum among women with hypertensive disorders of pregnancy at a tertiary hospital in Southwestern Uganda’ [AJOG Global Reports Volume 3, Issue 1, February 2023, 100163] Open
View article: Differential effects of glucagon-like peptide-1 receptor agonist classes on blood pressure: a systematic review and network meta-analysis of randomised controlled trials with meta-regression
Differential effects of glucagon-like peptide-1 receptor agonist classes on blood pressure: a systematic review and network meta-analysis of randomised controlled trials with meta-regression Open
Background and Aims: Recent clinical trials have reported blood pressure (BP)-lowering effects of glucagon-like peptide-1 receptor agonists (GLP1Ra). A recent systematic review has focused on the effects of semaglutide. However, there has …
View article: Exenatide and glucagon co-infusion increases myocardial glucose uptake and improves markers of diastolic dysfunction in adults with type 2 diabetes
Exenatide and glucagon co-infusion increases myocardial glucose uptake and improves markers of diastolic dysfunction in adults with type 2 diabetes Open
View article: ‘4 Ss’ for successful blood pressure control
‘4 Ss’ for successful blood pressure control Open
View article: A pathway toward clinical translation of hyperpolarized [1,4‐<scp><sup>13</sup>C<sub>2</sub></scp>,2,3‐d<sub>2</sub>]fumarate as an imaging biomarker for early cellular necrosis in vivo
A pathway toward clinical translation of hyperpolarized [1,4‐<span><sup>13</sup>C<sub>2</sub></span>,2,3‐d<sub>2</sub>]fumarate as an imaging biomarker for early cellular necrosis in vivo Open
Purpose The detection of hyperpolarized carbon‐13 (HP 13 C)‐fumarate conversion to 13 C‐malate using 13 C‐MRSI is a biomarker for early detection of cellular necrosis. Here, we describe the translation of HP 13 C‐fumarate as a novel human …
View article: Postpartum Cardiovascular Health in African Women Following Pre‐Eclampsia: A Prospective Cohort Study
Postpartum Cardiovascular Health in African Women Following Pre‐Eclampsia: A Prospective Cohort Study Open
Objective To investigate the prevalence of hypertension and cardiovascular dysfunction 1 year postpartum in Black African women who experienced pre‐eclampsia in a low‐resource setting in Uganda. Design Prospective cohort study. Setting Ter…
View article: British and Irish Hypertension Society response to ‘RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines’
British and Irish Hypertension Society response to ‘RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines’ Open
In their review of clinical practice guidelines on the use of renin-angiotensin-aldosterone system (RAAS) inhibitors, Greenlees and Delles call for more explicit advice on the use of these drugs among women of childbearing potential, durin…
View article: Blood pressure variability: a review
Blood pressure variability: a review Open
Blood pressure variability (BPV) predicts cardiovascular events independent of mean blood pressure. BPV is defined as short-term (24-h), medium or long- term (weeks, months or years). Standard deviation, coefficient of variation and variat…
View article: Haemodynamic changes from prepregnancy to very early pregnancy among women planning to conceive in Southwestern Uganda
Haemodynamic changes from prepregnancy to very early pregnancy among women planning to conceive in Southwestern Uganda Open
Introduction: Normal pregnancy is associated with cardiovascular changes that enable adaptation to the pregnancy state. We sought to describe the haemodynamic changes from prepregnancy to very early pregnancy in women planning to conceive …
View article: Dysregulation of lipid mediators in patients with frequent exacerbations of COPD
Dysregulation of lipid mediators in patients with frequent exacerbations of COPD Open
Introduction Specialised pro-resolving mediators (SPMs) are endogenously produced lipid mediators (LMs) that regulate the propagation of inflammation and promote tissue repair. We hypothesised that SPM production is dysregulated in COPD an…
View article: Investigation and management of resistant hypertension: British and Irish Hypertension Society position statement
Investigation and management of resistant hypertension: British and Irish Hypertension Society position statement Open
People living with resistant hypertension (RH) are at high risk of adverse cardiovascular events. The British and Irish Hypertension Society has identified suspected RH as a condition for which specialist guidance may improve rates of bloo…
View article: Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors
Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors Open
A critical attribute of therapeutic antibodies is their ability to engage with humoral or cellular effector mechanisms, and this depends on the ability of the Fc region to bind to complement (C1q) or Fc receptors. Investigators have sought…
View article: Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors
Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors Open
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been used in the c…
View article: Cardiovascular responses to experimental weight gain in humans: a feasibility study
Cardiovascular responses to experimental weight gain in humans: a feasibility study Open
Objective: Obesity and hypertension share a well known association. However, the mechanisms underlying their relationship are not well understood. Our goal was to assess the feasibility of a longitudinal, interventional weight gain study w…
View article: Investigation and management of young-onset hypertension: British and Irish hypertension society position statement
Investigation and management of young-onset hypertension: British and Irish hypertension society position statement Open
View article: Quantitative 23Na magnetic resonance imaging in the abdomen at 3 T
Quantitative 23Na magnetic resonance imaging in the abdomen at 3 T Open
View article: Oxidative DNA damage promotes vascular ageing associated with changes in extracellular matrix-regulating proteins
Oxidative DNA damage promotes vascular ageing associated with changes in extracellular matrix-regulating proteins Open
Aims Vascular ageing is characterized by vessel stiffening, with increased deposition of extracellular matrix (ECM) proteins including collagens. Oxidative DNA damage occurs in vascular ageing, but how it regulates ECM proteins and vascula…
View article: P25 Preconception to pOst-partum study of cardiometabolic health in Primigravid PregnancY: POPPY
P25 Preconception to pOst-partum study of cardiometabolic health in Primigravid PregnancY: POPPY Open
Previous studies demonstrated that placental syndromes, including pre-eclampsia, gestational hypertension and fetal growth restriction are associated with an increased risk of maternal hypertension, diabetes and cardiovascular disease (CV…
View article: Renal Autotransplantation for Uncontrolled Hypertension in Nonatherosclerotic Renal Artery Stenosis—2 Case Reports and a Brief Review of the Literature
Renal Autotransplantation for Uncontrolled Hypertension in Nonatherosclerotic Renal Artery Stenosis—2 Case Reports and a Brief Review of the Literature Open
Fibromuscular dysplasia is the most common cause of renovascular hypertension in young adults under 40 years old. It is potentially amenable to renal artery angioplasty, which frequently normalizes blood pressure. However, limited options …
View article: A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic Chronic Subdural Haematoma (Dex-CSDH trial)
A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic Chronic Subdural Haematoma (Dex-CSDH trial) Open
Background Chronic subdural haematoma is a collection of ‘old blood’ and its breakdown products in the subdural space and predominantly affects older people. Surgical evacuation remains the mainstay in the management of symptomatic cases. …
View article: Specialist hypertension clinics: an essential pathway but under-resourced
Specialist hypertension clinics: an essential pathway but under-resourced Open
View article: Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases Open
Antibodies can block immune receptor engagement or trigger the receptor machinery to initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RP…
View article: Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement
Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement Open