Ian C. Han
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View article: Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells
Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells Open
View article: Real-world short-term outcomes after switching to fixed-interval anti-VEGF therapy for neovascular AMD during the COVID-19 pandemic
Real-world short-term outcomes after switching to fixed-interval anti-VEGF therapy for neovascular AMD during the COVID-19 pandemic Open
View article: Development of a Targeted Choroidal Injury Model for the Study of Retinal Degenerations and Therapeutic Cell Replacement
Development of a Targeted Choroidal Injury Model for the Study of Retinal Degenerations and Therapeutic Cell Replacement Open
Purpose Choroidal loss is an important pathophysiological step in many retinal diseases, but few reliable translational models of choroidal injury exist. Here, we report a new targeted choroidal injury model using bioconjugated saporins an…
View article: Device-free isolation of photoreceptor cells from patient iPSC-derived retinal organoids
Device-free isolation of photoreceptor cells from patient iPSC-derived retinal organoids Open
Autologous photoreceptor cell replacement is one of the most promising strategies currently being developed for the treatment of patients with inherited retinal degenerative blindness. Induced pluripotent stem cell-derived (iPSC-derived) r…
View article: Artificial intelligence‐quantified schisis volume as a structural endpoint for gene therapy clinical trials in X‐linked retinoschisis
Artificial intelligence‐quantified schisis volume as a structural endpoint for gene therapy clinical trials in X‐linked retinoschisis Open
Purpose To use artificial intelligence (AI) for quantifying schisis volume (ASV) in X‐linked retinoschisis (XLRS) for use as a structural endpoint in gene therapy clinical trials. Methods We used data from Singapore, the United Kingdom, th…
View article: Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells
Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells Open
Neurodegenerative conditions that affect the retina are currently the leading cause of incurable blindness in the developed world. Although gene and drug therapies are being developed to slow disease progression in some cases, restorative …
View article: Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2
Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2 Open
Purpose Patients with non-proliferative macular telangiectasia type 2 (MacTel) have ganglion cell layer (GCL) and nerve fibre layer (NFL) loss, but it is unclear whether the thinning is progressive. We quantified the change in retinal laye…
View article: Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration
Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration Open
In retinal diseases such as age-related macular degeneration (AMD) and choroideremia, a key pathophysiologic step is loss of endothelial cells of the choriocapillaris, the dense vascular bed required for maintaining health and function of …
View article: A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease
A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease Open
View article: CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa Open
Rhodopsin (RHO) mutations such as Pro23His are the leading cause of dominantly inherited retinitis pigmentosa in North America. As with other dominant retinal dystrophies, these mutations lead to production of a toxic protein produc…
View article: Demonstration of the pathogenicity of a common non-exomic mutation in <i>ABCA4</i> using iPSC-derived retinal organoids and retrospective clinical data
Demonstration of the pathogenicity of a common non-exomic mutation in <i>ABCA4</i> using iPSC-derived retinal organoids and retrospective clinical data Open
Mutations in ABCA4 are the most common cause of Mendelian retinal disease. Clinical evaluation of this gene is challenging because of its extreme allelic diversity, the large fraction of non-exomic mutations, and the wide range of associat…
View article: Gene Expression Within a Human Choroidal Neovascular Membrane Using Spatial Transcriptomics
Gene Expression Within a Human Choroidal Neovascular Membrane Using Spatial Transcriptomics Open
Overall, this study spatially analyzes gene expression across the retina, retinal pigment epithelium, and choroid in health and describes a set of candidate molecules that become dysregulated in macular neovascularization.
View article: GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS
GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS Open
Macular neovascularization is a relatively common and potentially visually devastating complication of age-related macular degeneration. In macular neovascularization, pathologic angiogenesis can originate from either the choroid or the re…
View article: Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials
Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials Open
Introduction X-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1 . Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA). …
View article: Modeling rod and cone photoreceptor cell survival in vivo using optical coherence tomography
Modeling rod and cone photoreceptor cell survival in vivo using optical coherence tomography Open
Many retinal diseases involve the loss of light-sensing photoreceptor cells (rods and cones) over time. The severity and distribution of photoreceptor loss varies widely across diseases and affected individuals, so characterizing the degre…
View article: MACULAR ATROPHY AND PHENOTYPIC VARIABILITY IN AUTOSOMAL DOMINANT STARGARDT-LIKE MACULAR DYSTROPHY DUE TO PROM1 MUTATION
MACULAR ATROPHY AND PHENOTYPIC VARIABILITY IN AUTOSOMAL DOMINANT STARGARDT-LIKE MACULAR DYSTROPHY DUE TO PROM1 MUTATION Open
Purpose: To describe the phenotypic variability and rates of progression of atrophy in patients with PROM1 -associated macular dystrophy. Methods: Patients in this retrospective, longitudinal case series from a tertiary center had clinical…
View article: The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal
The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal Open
Adeno-associated virus (AAV)-mediated gene therapy has great potential for treating a wide range of retinal degenerative diseases. However, some initial enthusiasm for gene therapy has been tempered by emerging evidence of AAV-associated i…
View article: Retinal Sublayer Analysis in Autoimmune Retinopathy and Identification of New Optical Coherence Tomography Phenotypes
Retinal Sublayer Analysis in Autoimmune Retinopathy and Identification of New Optical Coherence Tomography Phenotypes Open
Autoimmune retinopathy (AIR) is a poorly characterized disease with a wide phenotypic spectrum, complicating investigations of its underlying pathophysiology. We sought to analyze optical coherence tomography (OCT) retinal thickness change…
View article: Choroidal Neovascularization Is Common in Best Vitelliform Macular Dystrophy and Plays a Role in Vitelliform Lesion Evolution
Choroidal Neovascularization Is Common in Best Vitelliform Macular Dystrophy and Plays a Role in Vitelliform Lesion Evolution Open
View article: Modeling rod and cone photoreceptor cell survival<i>in vivo</i>using optical coherence tomography
Modeling rod and cone photoreceptor cell survival<i>in vivo</i>using optical coherence tomography Open
Many retinal diseases involve the loss of light-sensing photoreceptor cells (rods and cones) over time. The severity and distribution of photoreceptor loss varies widely across diseases and affected individuals, so characterizing the degre…
View article: Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration
Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration Open
To describe a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) in non-neovascular age-related macular degeneration (AMD). Patients suffering from non-neovascular AMD with comp…
View article: Sub-retinal pigment epithelium tubules in non- neovascular age-related macular degeneration
Sub-retinal pigment epithelium tubules in non- neovascular age-related macular degeneration Open
Purpose To describe a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) in non-neovascular age-related macular degeneration (AMD). Methods Patients suffering from non-neovascul…
View article: Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial
Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial Open
CEP290-associated Leber congenital amaurosis type 10 (LCA10) is a retinal disease resulting in childhood blindness. Sepofarsen is an RNA antisense oligonucleotide targeting the c.2991+1655A>G variant in the CEP290 gene to treat LCA10. In t…
View article: Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration
Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration Open
The human choroid is a heterogeneous, highly vascular connective tissue that dysfunctions in age-related macular degeneration (AMD). In this study, we performed single-cell RNA sequencing on 21 human choroids, 11 of which were derived from…
View article: Biocompatibility of Human Induced Pluripotent Stem Cell–Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats
Biocompatibility of Human Induced Pluripotent Stem Cell–Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats Open
Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will b…
View article: Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy
Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy Open
Objective To correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients with Best vitelliform macular dystrophy (BVMD). Methods and analysis This is a …
View article: Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants
Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants Open
Purpose: Despite numerous recent advances in retinal gene therapy using adeno-associated viruses (AAVs) as delivery vectors, there remains a crucial need to identify viral vectors with the ability to transduce specific retina…
View article: Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa
Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa Open
View article: Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease
Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease Open
View article: Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)
Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV) Open