Ian C. Hsu
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View article: CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction
CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction Open
These preclinical trials provide the first evidence of cluster of differentiation 14 (CD14) blockade with a murine analogue of atibuclimab, a CD14-neutralizing antibody, preventing secondary immunological exacerbation of cardiac injury in …
View article: CD14 blockade in a translational model of reperfused ST-elevation myocardial infarction with key clinical features.
CD14 blockade in a translational model of reperfused ST-elevation myocardial infarction with key clinical features. Open
CD14 is a widely validated marker for monocyte/macrophage activity as well as an inflammatory biomarker and upstream regulator of macrophage activity. We herein test the hypothesis that interventional CD14 blockade with a murine analogue o…
View article: Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis
Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis Open
Cardiac fibrosis is a major cause of cardiac dysfunction. Recently, single-cell genomic approaches have revealed in unprecedented resolution the orchestrated cellular responses driving cardiac fibrosis. Yet, the fibrosis-causing phenotypes…
View article: Single-nucleus RNA sequencing reveals cellular and molecular dynamics of white and brown adipose tissue in a mouse model of type-2 diabetes
Single-nucleus RNA sequencing reveals cellular and molecular dynamics of white and brown adipose tissue in a mouse model of type-2 diabetes Open
Summary Excessive adipose tissue expansion is often linked with type-2 diabetes. Despite recent efforts mapping adipose tissue changes in obesity using single-cell omics, an understanding of cellular and gene expression changes in a model …
View article: Mapping the cellular and molecular landscape of cardiac non-myocytes in murine diabetic cardiomyopathy
Mapping the cellular and molecular landscape of cardiac non-myocytes in murine diabetic cardiomyopathy Open
View article: Spatial Mapping of Fibroblast Distribution and Heterogeneity Reveals Striking Sex-Specific Patterns of Hypertension-Induced Cardiac Fibrosis
Spatial Mapping of Fibroblast Distribution and Heterogeneity Reveals Striking Sex-Specific Patterns of Hypertension-Induced Cardiac Fibrosis Open
View article: Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice Open
View article: Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice Open
Coronary microvascular dysfunction (CMD) is associated with cardiac dysfunction and predictive of cardiac mortality in obesity, especially in females. Emerging evidence suggests development of heart failure with preserved ejection fraction…
View article: Depression, Anxiety, and Acute Stress Disorder Among Patients Hospitalized With COVID-19: A Prospective Cohort Study
Depression, Anxiety, and Acute Stress Disorder Among Patients Hospitalized With COVID-19: A Prospective Cohort Study Open
View article: Evaluation of plant seed DNA and botanical evidence for potential forensic applications
Evaluation of plant seed DNA and botanical evidence for potential forensic applications Open
Seeds, the reproductive organs of plants, are common as trace evidence from crime scenes. Seed evidence could be grouped into several categories based on the types of crimes they are associated with, including child abuse, homicides and dr…
View article: THE INTRODUCTION OF TRAJECTORY OSCILLATIONS TO REDUCE EMITTANCE GROWTH IN THE SLC LINAC
THE INTRODUCTION OF TRAJECTORY OSCILLATIONS TO REDUCE EMITTANCE GROWTH IN THE SLC LINAC Open
Emittance growth of accelerated beams in the 50 GeV linear accelerator of the Stanford Linear Collider (SLC) arises from the effects of transverse wakefields and momentum dispersion. These effects are caused by small misalignments of the b…
View article: Freezing shortens the lifetime of DNA molecules under tension
Freezing shortens the lifetime of DNA molecules under tension Open
View article: The Classification of <i>Sini</i> Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling
The Classification of <i>Sini</i> Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling Open
We investigated the syndromes of the Sini decoction pattern (SDP), a common ZHENG in traditional Chinese medicine (TCM). The syndromes of SDP were correlated with various severe Yang deficiency related symptoms. To obtain a common profile …