Ian Yi‐Feng Chang
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View article: EPCO-14. QPC-GBM DECONVOLUTION REVEALS OPPOSING PROGNOSTIC ROLES OF GLIOMA-ASSOCIATED MYELOID AND ENDOTHELIAL CELLS IN GLIOBLASTOMA
EPCO-14. QPC-GBM DECONVOLUTION REVEALS OPPOSING PROGNOSTIC ROLES OF GLIOMA-ASSOCIATED MYELOID AND ENDOTHELIAL CELLS IN GLIOBLASTOMA Open
Glioblastoma (GBM) is a highly malignant brain tumor that becomes resistance to current therapy partially due to interactions between tumor cells and tumor microenvironment (TME). To further understand these interactions and its patient pr…
View article: Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-mediated pneumonia
Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-mediated pneumonia Open
Introduction Commensal bacterial community along the upper respiratory tract functions against pathogens. The host determinants of Mycoplasma pneumoniae severity should be identified against the increasing threat of macrolide-resistant M. …
View article: The development and application of Taiwan HD Maps for smart mobile mapping technology
The development and application of Taiwan HD Maps for smart mobile mapping technology Open
The rapid advancement of Intelligent Transport Systems (ITS) has significantly propelled the development of autonomous vehicle technologies in recent years. HD Maps are crucial for autonomous driving technology due to their high accuracy, …
View article: Mapping in the Future: Advancing HD Maps Creation with Semi-Automated Feature Extraction
Mapping in the Future: Advancing HD Maps Creation with Semi-Automated Feature Extraction Open
The production of high-definition maps (HD Maps) is a multi-stage, resource-intensive process that demands substantial investments in specialized equipment, skilled labor, and time. This study introduces a semi-automated mapping tool aimed…
View article: Genomic and transcriptomic insights into the virulence and adaptation of shock syndrome-causing Streptococcus anginosus
Genomic and transcriptomic insights into the virulence and adaptation of shock syndrome-causing Streptococcus anginosus Open
Streptococcus anginosus is a common isolate of the oral cavity and an opportunistic pathogen for systemic infections. Although the pyogenic infections caused by S. anginosus are similar to those caused by Streptococcus pyogenes , S. angino…
View article: P-2011. Blood Transcriptomic Stratification for Acute Encephalitis/encephalopathy and Croup in Children with Omicron Infection
P-2011. Blood Transcriptomic Stratification for Acute Encephalitis/encephalopathy and Croup in Children with Omicron Infection Open
Background Omicron poses significant concerns, leading to two severe complications, encephalitis and croup in children. Neutrophil predominance and lymphopenia were observed in severe cases. We propose a distinctive blood RNA signature to …
View article: Utilizing TP53 hotspot mutations as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer
Utilizing TP53 hotspot mutations as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer Open
TP53 mutations are recognized to correlate with a worse prognosis in individuals with non-small cell lung cancer (NSCLC). There exists an immediate necessity to pinpoint selective treatment for patients carrying TP53 mutations. Potential d…
View article: Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies
Integrated multi-omics analyses of oral squamous cell carcinoma reveal precision patient stratification and personalized treatment strategies Open
Oral cavity squamous cell carcinoma (OSCC), a leading subtype of head and neck cancer, exhibits high global incidence and mortality rates. Despite advancements in surgery and radiochemotherapy, approximately one-third of patients experienc…
View article: Redefining aberrant P53 expression of gastric cancer and its distinct clinical significance among molecular-histologic subtypes
Redefining aberrant P53 expression of gastric cancer and its distinct clinical significance among molecular-histologic subtypes Open
P53 IHC patterns are predictive biomarkers for mutTP53 and gastric cancer outcomes, where a prerequisite involves a nuanced approach considering cutoff values and molecular-histologic subtyping.
View article: PATH-05. PRIMARY AND SECONDARY GLIOSARCOMA: RADIOLOGICAL AND PROGNOSTIC DIFFERENCES USING COMPREHENSIVE MULTI-OMICS ANALYSIS
PATH-05. PRIMARY AND SECONDARY GLIOSARCOMA: RADIOLOGICAL AND PROGNOSTIC DIFFERENCES USING COMPREHENSIVE MULTI-OMICS ANALYSIS Open
Purpose Gliosarcoma (GS), a rare variant of glioblastoma (GB), is further classified into primary (de novo) gliosarcoma (PGS), and secondary gliosarcoma (SGS), which is defined as recurrence after a diagnosis of diffuse glioma. Poorer surv…
View article: CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden
CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden Open
CAN008 combined with standard CCRT treatment prolonged the PFS and OS of newly diagnosed GBM patients compared to standard therapy alone. Higher treatment efficacy was associated with higher TMB.
View article: Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression
Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression Open
Recent findings have implicated long noncoding RNAs (lncRNAs) as pivotal gene regulators for diverse biological processes, despite their lack of protein-coding capabilities. Accumulating evidence suggests the significance of lncRNAs in med…
View article: EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response
EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response Open
Purpose Molecular composition of circulating small extracellular vesicles (EVs) does not merely reflect the cells of origin, but also is enriched in specific biomolecules directly associated with the cellular transformation. However, while…
View article: Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma
Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma Open
Background Oral cavity squamous cell carcinoma (OSCC) is an aggressive malignant tumor with high recurrence and poor prognosis in the advanced stage. Patient-derived xenografts (PDXs) serve as powerful preclinical platforms for drug testin…
View article: Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy
Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy Open
Colorectal cancer (CRC) is a major cause of cancer mortality and morbidity. Despite advances in chemotherapy and targeted therapy, unsustainable clinical benefit was noted due to recurrence and therapy resistance. The immune status of the …
View article: Global Genome Diversity and Recombination in <i>Mycoplasma pneumoniae</i>
Global Genome Diversity and Recombination in <i>Mycoplasma pneumoniae</i> Open
Genomic changes in Mycoplasma pneumoniae caused by adaptation to environmental or ecologic pressures are poorly understood. We collected M. pneumoniae from children who had confirmed pneumonia in Taiwan during 2017-2020. We used whole-geno…
View article: Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1‐STAT1 loop in lung adenocarcinoma
Nuclear accumulation of KPNA2 impacts radioresistance through positive regulation of the PLSCR1‐STAT1 loop in lung adenocarcinoma Open
Lung adenocarcinoma (ADC) is the predominant histological type of lung cancer, and radiotherapy is one of the current therapeutic strategies for lung cancer treatment. Unfortunately, biological complexity and cancer heterogeneity contribut…
View article: Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients
Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients Open
Gliomas are solid tumors that originate from glial cells in the brain or spine and account for 74.6% of malignant primary central nervous system tumors worldwide. As patient-derived primary cells are important tools for drug screening and …
View article: Comprehensive functional genomic analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III colorectal cancer patients
Comprehensive functional genomic analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III colorectal cancer patients Open
For stage III CRC, patients with mutated APC had better overall and recurrence free survival.
View article: The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes
The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes Open
The clinicopathological significance of altered SWI/SNF complex has not been well evaluated in gastric cancer (GC). We examined SMARCA2, SMARCA4, SMARCB1 and ARID1A expression by immunohistochemistry in 1224 surgically resected GCs with su…
View article: ASC modulates HIF-1α stability and induces cell mobility in OSCC
ASC modulates HIF-1α stability and induces cell mobility in OSCC Open
High-level expression of ASC (Apoptosis-associated speck-like protein containing a CARD) leads to lymph node metastasis in OSCC, but the underlying mechanism remains unclear. Here, we show that HIF-1α participates in ASC-induced metastasis…
View article: Anti–IFN-γ autoantibodies underlie disseminated<i>Talaromyces marneffei</i>infections
Anti–IFN-γ autoantibodies underlie disseminated<i>Talaromyces marneffei</i>infections Open
Talaromyces marneffei causes life-threatening opportunistic infections, mainly in Southeast Asia and South China. T. marneffei mainly infects patients with human immunodeficiency virus (HIV) but also infects individuals without known immun…
View article: Verification of Saliva Matrix Metalloproteinase-1 as a Strong Diagnostic Marker of Oral Cavity Cancer
Verification of Saliva Matrix Metalloproteinase-1 as a Strong Diagnostic Marker of Oral Cavity Cancer Open
Oral squamous cell carcinoma (OSCC) accounts for >90% of cases of oral cancer, including cancer at the lip and oral cavity and cancer at the oropharynx. Most OSCCs develop from oral potentially malignant disorders (OPMDs), which consist of…
View article: circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response
circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response Open
Deep sequencing technologies have revealed the once uncharted non-coding transcriptome of circular RNAs (circRNAs). Despite the lack of protein-coding potential, these unorthodox yet highly stable RNA species are known to act as critical g…