Ian E. Brown
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View article: Metabolomic assessment of low versus high volume resuscitation in a combined porcine model of severe burn and traumatic brain injury
Metabolomic assessment of low versus high volume resuscitation in a combined porcine model of severe burn and traumatic brain injury Open
Background: Severe burns continue to be associated with significant morbidity and mortality despite advances in resuscitation techniques. Concomitant injury such as traumatic brain injury adds complexity to resuscitation paradigms as high …
View article: ANGPTL7 and Its Role in IOP and Glaucoma
ANGPTL7 and Its Role in IOP and Glaucoma Open
Using multiple models, we have demonstrated that excess ANGPTL7 increases outflow resistance and IOP and that neutralizing ANGPTL7 has beneficial effects in both naïve and steroid-induced hypertensive eyes, thus motivating the development …
View article: Data from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma
Data from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma Open
Purpose: To investigate the antitumor efficacy of T-cell anergy reversal through homeostatic proliferation and regulatory T-cell (Treg) depletion in a clinically relevant murine adoptive immunotherapy model.Experimental Design:
View article: Supplementary Figures S1-S2 from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma
Supplementary Figures S1-S2 from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma Open
Supplementary Figures S1-S2 from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma
View article: Data from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma
Data from Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma Open
Purpose: To investigate the antitumor efficacy of T-cell anergy reversal through homeostatic proliferation and regulatory T-cell (Treg) depletion in a clinically relevant murine adoptive immunotherapy model.Experimental Design:
View article: Assessment of Neurological Impairment and Recovery Using Statistical Models of Neurologically Healthy Behavior
Assessment of Neurological Impairment and Recovery Using Statistical Models of Neurologically Healthy Behavior Open
While many areas of medicine have benefited from the development of objective assessment tools and biomarkers, there have been comparatively few improvements in techniques used to assess brain function and dysfunction. Brain functions such…
View article: Getting around the gut: a unique management challenge of thyroid storm precipitated by amphetamine-associated duodenal ischaemia leading to compromised enteric absorption
Getting around the gut: a unique management challenge of thyroid storm precipitated by amphetamine-associated duodenal ischaemia leading to compromised enteric absorption Open
Thyroid storm is a rare, life-threatening endocrine emergency with a high mortality rate of up to 30%. We present a unique management challenge of a critically ill patient who developed thyroid storm in the setting of a duodenal perforatio…