Ian Forgie
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View article: Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study
Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study Open
Here we report the results from exploratory analysis using a Bayesian network approach of data originally derived from a large North European study of type 2 diabetes (T2D) conducted by the IMI DIRECT consortium. 3029 individuals (795 with…
View article: The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study
The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study Open
View article: Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits Open
View article: Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models Open
View article: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models Open
View article: Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials Open
View article: Pharmacogenomics of GLP-1 Receptor Agonists: A genome wide analysis of observational data and large randomized controlled trials
Pharmacogenomics of GLP-1 Receptor Agonists: A genome wide analysis of observational data and large randomized controlled trials Open
Summary Background In the treatment of type 2 diabetes (T2D), GLP-1 Receptor Agonists (GLP-1RA) lower glucose levels and body weight, and have cardiovascular benefits. GLP-1RA efficacy and side effects vary between people. Human pharmacoge…
View article: Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study Open
View article: Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study
Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study Open
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and m…
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured.…
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured.…
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 mo…
View article: Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study
Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study Open
Genetic variants identified by genome-wide association studies can contribute to disease risk by altering the production and abundance of mRNA, proteins and other molecules. However, the interplay between molecular intermediaries that defi…
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
Objective We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). Research Design and Methods 732 recently diagnosed T2D patients from the IMI-DIRECT study were extensively phenotyped over…
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
Objective We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). Research Design and Methods 732 recently diagnosed T2D patients from the IMI-DIRECT study were extensively phenotyped over…
View article: Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Open
View article: Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study Open
Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-…
View article: Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study Open
View article: Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study
Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study Open
Aim To examine the hypothesis that, based on their glucose curves during a seven‐point oral glucose tolerance test, people at elevated type 2 diabetes risk can be divided into subgroups with different clinical profiles at baseline and diff…
View article: Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts Open
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreve…
View article: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study
Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study Open
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) and beyond. Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to th…
View article: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study Open
Aims/hypothesis It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) pr…
View article: Additional file 3 of Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Additional file 3 of Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Open
Additional file 3. Supplementary Tables. This file contains Tables. S1 – S14.
View article: Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium Open
View article: Motivations for data sharing—views of research participants from four European countries: A DIRECT study
Motivations for data sharing—views of research participants from four European countries: A DIRECT study Open
View article: Sharing data for future research'engaging participants' views about data governance beyond the original project: a DIRECT Study
Sharing data for future research'engaging participants' views about data governance beyond the original project: a DIRECT Study Open
View article: The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project
The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project Open
View article: Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium Open
/Summary Background and aims: Understanding the aetiology, clinical presentation and prognosis of type 2 diabetes (T2D) and optimizing its treatment might be facilitated by biomarkers that help predict a person’s susceptibility to the risk…