Ian Fotheringham
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View article: Epidermicin NI01, a First-in-Class Peptide Antibiotic Candidate, Has Potent Efficacy in a Robust MRSA Wound Infection Model and Low Allergic Reaction Liabilities
Epidermicin NI01, a First-in-Class Peptide Antibiotic Candidate, Has Potent Efficacy in a Robust MRSA Wound Infection Model and Low Allergic Reaction Liabilities Open
View article: Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals
Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals Open
Immunization with mosaic-8b (nanoparticles presenting 8 SARS-like betacoronavirus [sarbecovirus] receptor-binding domains [RBDs]) elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticles and protects …
View article: Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals
Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals Open
SUMMARY Immunization with mosaic-8b [60-mer nanoparticles presenting 8 SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticle…
View article: The fluorescent protein iLOV as a reporter for screening of high‐yield production of antimicrobial peptides in <i>Pichia pastoris</i>
The fluorescent protein iLOV as a reporter for screening of high‐yield production of antimicrobial peptides in <i>Pichia pastoris</i> Open
Summary The methylotrophic yeast Pichia pastoris is commonly used for the production of recombinant proteins at scale. The identification of an optimally overexpressing strain following transformation can be time and reagent consuming. Flu…
View article: Development and validation of ester impregnated pH strips for locating nasogastric feeding tubes in the stomach—a multicentre prospective diagnostic performance study
Development and validation of ester impregnated pH strips for locating nasogastric feeding tubes in the stomach—a multicentre prospective diagnostic performance study Open
View article: Engineering <i>Pseudomonas putida</i> KT2440 for the production of isobutanol
Engineering <i>Pseudomonas putida</i> KT2440 for the production of isobutanol Open
We engineered P. putida for the production of isobutanol from glucose by preventing product and precursor degradation, inactivation of the soluble transhydrogenase SthA, overexpression of the native ilvC and ilvD genes, and implementation …
View article: A Review of Bioinformatics Tools for Bio-Prospecting from Metagenomic Sequence Data
A Review of Bioinformatics Tools for Bio-Prospecting from Metagenomic Sequence Data Open
The microbiome can be defined as the community of microorganisms that live in a particular environment. Metagenomics is the practice of sequencing DNA from the genomes of all organisms present in a particular sample, and has become a commo…